Nuclear envelope protein lamin B receptor protects the genome from chromosomal instability and tumorigenesis

Abstract Lamin B Receptor (LBR) is an inner nuclear membrane protein that assembles the nuclear envelope post mitosis. Here we show that LBR depletion induces mitotic defects accompanied by recurrent chromosomal losses. In addition, LBR knockdown results in nuclear aberrations such as nuclear blebs...

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Veröffentlicht in:	Human molecular genetics 2023-02, Vol.32 (5), p.745-763
Hauptverfasser:	Patil, Shalaka, Deshpande, Shruti, Sengupta, Kundan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinogenesis Chromosomal Instability Humans Lamin B Receptor Lamin Type B - metabolism Membrane Proteins - metabolism Mice Nuclear Envelope - metabolism Receptors, Cytoplasmic and Nuclear
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