Ru()-catalyzed external auxiliary-free primary amide-directed inverse Sonogashira reaction on (hetero)arylamides

Ru()-catalyzed external auxiliary-free primary amide-directed inverse Sonogashira reaction on (hetero)arylamides

Herein, we report ruthenium( ii )-catalyzed weakly coordinating primary amide-assisted ortho -di-alkynylation of (hetero)arylamides via double C-H bond activation in the presence of bromo-alkynes as coupling partners. The attractive features of the developed strategy lie in the usage of an inexpensi...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2022-10, Vol.58 (8), p.1134-1137
Hauptverfasser: Baghel, Akanksha Singh, Kumar, Amit
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Sprache:eng
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Alkynes
Chemical synthesis
Hydrogen bonds
Ruthenium
Ruthenium compounds
Substrates
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Kumar, Amit
description Herein, we report ruthenium( ii )-catalyzed weakly coordinating primary amide-assisted ortho -di-alkynylation of (hetero)arylamides via double C-H bond activation in the presence of bromo-alkynes as coupling partners. The attractive features of the developed strategy lie in the usage of an inexpensive ruthenium( ii )-salt, external auxiliary-free directing group and simple reaction conditions, along with a broad substrate scope, high reaction yields and scale-up synthesis. An effective protocol has been developed for the mono/di-alkynylation of (hetero)arylamides via double C-H bond activation with bromo-alkynes as coupling partners using the primary amide as a directing group in the presence of a ruthenium( ii )-salt.
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Alkynes
Chemical synthesis
Hydrogen bonds
Ruthenium
Ruthenium compounds
Substrates
title Ru()-catalyzed external auxiliary-free primary amide-directed inverse Sonogashira reaction on (hetero)arylamides
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