Stable amorphous solid dispersion of flubendazole with high loading via electrospinning

In this work, an important step is taken towards the bioavailability improvement of poorly water-soluble drugs, such as flubendazole (Flu), posing a challenge in the current development of many novel oral-administrable therapeutics. Solvent electrospinning of a solution of the drug and poly (2-ethyl...

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Veröffentlicht in:	Journal of controlled release 2022-11, Vol.351, p.123-136
Hauptverfasser:	Becelaere, Jana, Van Den Broeck, Elias, Schoolaert, Ella, Vanhoorne, Valérie, Van Guyse, Joachim F.R., Vergaelen, Maarten, Borgmans, Sander, Creemers, Karolien, Van Speybroeck, Veronique, Vervaet, Chris, Hoogenboom, Richard, De Clerck, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amorphous solid dispersions Computational chemistry Flubendazole Molecular dynamics Poly(2-ethyl-2-oxazoline) Solvent electrospinning
Online-Zugang:	Volltext
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