Sexual Dimorphism in the Expression of Cytochrome P450 Enzymes in Rat Heart, Liver, Kidney, Lung, Brain, and Small Intestine

Cytochrome P450 (P450) enzymes are monooxygenases that are expressed hepatically and extrahepatically and play an essential role in xenobiotic metabolism. Substantial scientific evidence indicates sex-specific differences between males and females in disease patterns and drug responses, which could...

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Veröffentlicht in:	Drug metabolism and disposition 2023-01, Vol.51 (1), p.81-94
Hauptverfasser:	Gerges, Samar H, El-Kadi, Ayman O S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - metabolism Cytochrome P-450 Enzyme System - metabolism Female Intestine, Small - metabolism Kidney - metabolism Liver - metabolism Lung - metabolism Male Microsomes, Liver - metabolism Rats Rats, Sprague-Dawley RNA, Messenger - analysis Sex Characteristics
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