Complex functional phenotypes of NMDA receptor disease variants

NMDA receptors have essential roles in the physiology of central excitatory synapses and their dysfunction causes severe neuropsychiatric symptoms. Recently, a series of genetic variants have been identified in patients, however, functional information about these variants is sparse and their role i...

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Veröffentlicht in:	Molecular psychiatry 2022-12, Vol.27 (12), p.5113-5123
Hauptverfasser:	Iacobucci, Gary J., Liu, Beiying, Wen, Han, Sincox, Brittany, Zheng, Wenjun, Popescu, Gabriela K.
Format:	Artikel
Sprache:	eng
Schlagworte:	13/109 631/337 631/378 631/45 692/699/476 9/74 Amino acid sequence Behavioral Sciences Binding sites Biological Psychology Channel gating Electrophysiological Phenomena Electrophysiology Genetic diversity Glutamic acid receptors (ionotropic) Ligands Medicine Medicine & Public Health Mental disorders Molecular dynamics Mutation N-Methyl-D-aspartic acid receptors Neurosciences Permeability Pharmacotherapy Phenotype Phenotypes Physiology Psychiatry Receptor mechanisms Receptors, N-Methyl-D-Aspartate - genetics Software Synapses
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