The effect of 3 % hydrogen peroxide irrigation on postoperative complications of rhinoplasty: A double-blinded, placebo-controlled Randomized Clinical Trial
The aim of this study was to evaluate the effect of irrigation with 3% Hydrogen Peroxide solution on early complications of rhinoplasty. Volunteers who had physical status of ASA I were included in the study after informed written consent. This was a randomized, double-blinded, placebo-controlled cl...
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| Veröffentlicht in: | Journal of cranio-maxillo-facial surgery 2022-09, Vol.50 (9), p.681-685 |
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| container_title | Journal of cranio-maxillo-facial surgery |
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| creator | Maghsoudipour, Negin Mohammadi, Arash Nazari, Hesamedin Nazari, Hamed Ziaei, Narges Amiri, Seyed Mojtaba |
| description | The aim of this study was to evaluate the effect of irrigation with 3% Hydrogen Peroxide solution on early complications of rhinoplasty. Volunteers who had physical status of ASA I were included in the study after informed written consent. This was a randomized, double-blinded, placebo-controlled clinical trial. Standard open rhinoplasty technique was performed for all patients. All patients underwent the same general anesthesia and post-operative analgesic protocol and the only difference between the two studied groups was the use of hydrogen peroxide for irrigation at the end of surgery. Finally, patients were examined for edema, inflammation, ecchymosis, and infections during 8 weeks after surgery. 50 volunteers (43 female and 7 male) with the mean age of 27.84 ± 7.64 were included in this study. Edema scores were constantly lower in the intervention group (p |
| doi_str_mv | 10.1016/j.jcms.2022.06.012 |
| format | Article |
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Volunteers who had physical status of ASA I were included in the study after informed written consent. This was a randomized, double-blinded, placebo-controlled clinical trial. Standard open rhinoplasty technique was performed for all patients. All patients underwent the same general anesthesia and post-operative analgesic protocol and the only difference between the two studied groups was the use of hydrogen peroxide for irrigation at the end of surgery. Finally, patients were examined for edema, inflammation, ecchymosis, and infections during 8 weeks after surgery. 50 volunteers (43 female and 7 male) with the mean age of 27.84 ± 7.64 were included in this study. Edema scores were constantly lower in the intervention group (p < 0.001), so was the median inflammation score (p < 0.001). However, there was no significant difference in ecchymosis between the two groups (p > 0.05). No cases of post-operative infection were reported in any of the study groups. In conclusion, within the limitations of the study, it seems that irrigation with H2O2 should be applied whenever appropriate, because of its potential positive effects.</description><identifier>ISSN: 1010-5182</identifier><identifier>EISSN: 1878-4119</identifier><identifier>DOI: 10.1016/j.jcms.2022.06.012</identifier><language>eng</language><publisher>Elsevier Ltd</publisher><subject>Edema ; Hydrogen-peroxide ; Post-operative ; Rhinoplasty</subject><ispartof>Journal of cranio-maxillo-facial surgery, 2022-09, Vol.50 (9), p.681-685</ispartof><rights>2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-4c7296cf3c77dcd5212162182f15f24559404ac2a7d9a6624c1416a4808cf2233</citedby><cites>FETCH-LOGICAL-c333t-4c7296cf3c77dcd5212162182f15f24559404ac2a7d9a6624c1416a4808cf2233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S101051822200097X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids></links><search><creatorcontrib>Maghsoudipour, Negin</creatorcontrib><creatorcontrib>Mohammadi, Arash</creatorcontrib><creatorcontrib>Nazari, Hesamedin</creatorcontrib><creatorcontrib>Nazari, Hamed</creatorcontrib><creatorcontrib>Ziaei, Narges</creatorcontrib><creatorcontrib>Amiri, Seyed Mojtaba</creatorcontrib><title>The effect of 3 % hydrogen peroxide irrigation on postoperative complications of rhinoplasty: A double-blinded, placebo-controlled Randomized Clinical Trial</title><title>Journal of cranio-maxillo-facial surgery</title><description>The aim of this study was to evaluate the effect of irrigation with 3% Hydrogen Peroxide solution on early complications of rhinoplasty. Volunteers who had physical status of ASA I were included in the study after informed written consent. This was a randomized, double-blinded, placebo-controlled clinical trial. Standard open rhinoplasty technique was performed for all patients. All patients underwent the same general anesthesia and post-operative analgesic protocol and the only difference between the two studied groups was the use of hydrogen peroxide for irrigation at the end of surgery. Finally, patients were examined for edema, inflammation, ecchymosis, and infections during 8 weeks after surgery. 50 volunteers (43 female and 7 male) with the mean age of 27.84 ± 7.64 were included in this study. Edema scores were constantly lower in the intervention group (p < 0.001), so was the median inflammation score (p < 0.001). However, there was no significant difference in ecchymosis between the two groups (p > 0.05). No cases of post-operative infection were reported in any of the study groups. In conclusion, within the limitations of the study, it seems that irrigation with H2O2 should be applied whenever appropriate, because of its potential positive effects.</description><subject>Edema</subject><subject>Hydrogen-peroxide</subject><subject>Post-operative</subject><subject>Rhinoplasty</subject><issn>1010-5182</issn><issn>1878-4119</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9Uc1q3DAQNiWFpmlfoCddCj3EjiTbsl1yCUvzA4FA2Z6FdjTKapE9ruQN3T5LH7babs-BgRnm-4GZryg-CV4JLtTVrtrBmCrJpay4qriQb4pz0Xd92QgxnOWZC162opfvivcp7TjnivfDefFnvUWGziEsjByr2We2PdhIzzixGSP98haZj9E_m8XTxHLNlBbKWF68IAMa5-DhH5qOFnHrJ5qDScvhK7thlvabgOUm-MmivWQZAdxQCTQtkUJAy76bydLof-dxlWnZLLB19CZ8KN46ExJ-_N8vih-339ar-_Lx6e5hdfNYQl3XS9lAJwcFroaus2BbKaRQMt_qROtk07ZDwxsD0nR2MErJBkQjlGl63oOTsq4vii8n3znSzz2mRY8-AYZgJqR90rITbTdwVbeZKk9UiJRSRKfn6EcTD1pwfYxC7_QxCn2MQnOlcxRZdH0SYT7ixWPUCTxOgNbH_Hhtyb8m_wturZQ3</recordid><startdate>202209</startdate><enddate>202209</enddate><creator>Maghsoudipour, Negin</creator><creator>Mohammadi, Arash</creator><creator>Nazari, Hesamedin</creator><creator>Nazari, Hamed</creator><creator>Ziaei, Narges</creator><creator>Amiri, Seyed Mojtaba</creator><general>Elsevier Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202209</creationdate><title>The effect of 3 % hydrogen peroxide irrigation on postoperative complications of rhinoplasty: A double-blinded, placebo-controlled Randomized Clinical Trial</title><author>Maghsoudipour, Negin ; Mohammadi, Arash ; Nazari, Hesamedin ; Nazari, Hamed ; Ziaei, Narges ; Amiri, Seyed Mojtaba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-4c7296cf3c77dcd5212162182f15f24559404ac2a7d9a6624c1416a4808cf2233</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Edema</topic><topic>Hydrogen-peroxide</topic><topic>Post-operative</topic><topic>Rhinoplasty</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maghsoudipour, Negin</creatorcontrib><creatorcontrib>Mohammadi, Arash</creatorcontrib><creatorcontrib>Nazari, Hesamedin</creatorcontrib><creatorcontrib>Nazari, Hamed</creatorcontrib><creatorcontrib>Ziaei, Narges</creatorcontrib><creatorcontrib>Amiri, Seyed Mojtaba</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cranio-maxillo-facial surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maghsoudipour, Negin</au><au>Mohammadi, Arash</au><au>Nazari, Hesamedin</au><au>Nazari, Hamed</au><au>Ziaei, Narges</au><au>Amiri, Seyed Mojtaba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of 3 % hydrogen peroxide irrigation on postoperative complications of rhinoplasty: A double-blinded, placebo-controlled Randomized Clinical Trial</atitle><jtitle>Journal of cranio-maxillo-facial surgery</jtitle><date>2022-09</date><risdate>2022</risdate><volume>50</volume><issue>9</issue><spage>681</spage><epage>685</epage><pages>681-685</pages><issn>1010-5182</issn><eissn>1878-4119</eissn><abstract>The aim of this study was to evaluate the effect of irrigation with 3% Hydrogen Peroxide solution on early complications of rhinoplasty. Volunteers who had physical status of ASA I were included in the study after informed written consent. This was a randomized, double-blinded, placebo-controlled clinical trial. Standard open rhinoplasty technique was performed for all patients. All patients underwent the same general anesthesia and post-operative analgesic protocol and the only difference between the two studied groups was the use of hydrogen peroxide for irrigation at the end of surgery. Finally, patients were examined for edema, inflammation, ecchymosis, and infections during 8 weeks after surgery. 50 volunteers (43 female and 7 male) with the mean age of 27.84 ± 7.64 were included in this study. Edema scores were constantly lower in the intervention group (p < 0.001), so was the median inflammation score (p < 0.001). However, there was no significant difference in ecchymosis between the two groups (p > 0.05). No cases of post-operative infection were reported in any of the study groups. In conclusion, within the limitations of the study, it seems that irrigation with H2O2 should be applied whenever appropriate, because of its potential positive effects.</abstract><pub>Elsevier Ltd</pub><doi>10.1016/j.jcms.2022.06.012</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of cranio-maxillo-facial surgery, 2022-09, Vol.50 (9), p.681-685 |
| issn | 1010-5182 1878-4119 |
| language | eng |
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| source | Elsevier ScienceDirect Journals |
| subjects | Edema Hydrogen-peroxide Post-operative Rhinoplasty |
| title | The effect of 3 % hydrogen peroxide irrigation on postoperative complications of rhinoplasty: A double-blinded, placebo-controlled Randomized Clinical Trial |
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