A prospective observational study to sequentially determine the dermoscopic features of vitiligo and its association with disease activity in patients on medical treatment: Dermoscopy and disease activity in vitiligo
Prospective data on correlation between dermoscopic features of vitiligo and disease activity are scarce. This study was conducted to sequentially determine the dermoscopic features of vitiligo and to evaluate their association with disease activity. A cohort of 30 patients with 60 active vitiligo p...
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| Veröffentlicht in: | Pigment cell and melanoma research 2023-01, Vol.36 (1), p.33-41 |
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| container_title | Pigment cell and melanoma research |
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| creator | Gupta, Priyansh Vinay, Keshavamurthy Bishnoi, Anuradha Kumaran, Muthu Sendhil Parsad, Davinder |
| description | Prospective data on correlation between dermoscopic features of vitiligo and disease activity are scarce. This study was conducted to sequentially determine the dermoscopic features of vitiligo and to evaluate their association with disease activity. A cohort of 30 patients with 60 active vitiligo patches on medical therapy was subjected to sequential clinical and dermoscopic examination at four weekly intervals till 16 weeks. Disease activity at each visit was assessed using serial clinical photographs and modified vitiligo activity severity index. The dermoscopic images were merged and analysed for a predefined set of dermoscopic parameters by two blinded dermatologists. Paired analysis of dermoscopic features was done between baseline, and stabilized vitiligo patches at 12 and 16 weeks. Pigment network changes (absent and reduced pigment network, p |
| doi_str_mv | 10.1111/pcmr.13069 |
| format | Article |
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This study was conducted to sequentially determine the dermoscopic features of vitiligo and to evaluate their association with disease activity. A cohort of 30 patients with 60 active vitiligo patches on medical therapy was subjected to sequential clinical and dermoscopic examination at four weekly intervals till 16 weeks. Disease activity at each visit was assessed using serial clinical photographs and modified vitiligo activity severity index. The dermoscopic images were merged and analysed for a predefined set of dermoscopic parameters by two blinded dermatologists. Paired analysis of dermoscopic features was done between baseline, and stabilized vitiligo patches at 12 and 16 weeks. Pigment network changes (absent and reduced pigment network, p < .001), perifollicular depigmentation (p = .02), ill-defined margins (p = .04) and satellite lesions and micro-Koebner phenomenon (p < .001) were associated with active vitiligo while perifollicular repigmentation (p < .001) was associated with stabilizing and repigmenting vitiligo. Satellite lesions and micro-Koebner's phenomena were suggestive of unstable disease irrespective of site of target lesion, while perifollicular repigmentation was suggestive of stabilized/repigmenting disease only at non-acral sites. We found sequential dermoscopy to be useful to assess disease activity and potential for repigmentation in localized vitiligo.</description><identifier>ISSN: 1755-1471</identifier><identifier>EISSN: 1755-148X</identifier><identifier>DOI: 10.1111/pcmr.13069</identifier><identifier>PMID: 36112075</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Dermoscopy - methods ; Health services ; Humans ; Lesions ; Medical treatment ; Observational studies ; Patients ; Prospective Studies ; Skin diseases ; Vitiligo ; Vitiligo - pathology</subject><ispartof>Pigment cell and melanoma research, 2023-01, Vol.36 (1), p.33-41</ispartof><rights>2022 John Wiley & Sons A/S. 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This study was conducted to sequentially determine the dermoscopic features of vitiligo and to evaluate their association with disease activity. A cohort of 30 patients with 60 active vitiligo patches on medical therapy was subjected to sequential clinical and dermoscopic examination at four weekly intervals till 16 weeks. Disease activity at each visit was assessed using serial clinical photographs and modified vitiligo activity severity index. The dermoscopic images were merged and analysed for a predefined set of dermoscopic parameters by two blinded dermatologists. Paired analysis of dermoscopic features was done between baseline, and stabilized vitiligo patches at 12 and 16 weeks. Pigment network changes (absent and reduced pigment network, p < .001), perifollicular depigmentation (p = .02), ill-defined margins (p = .04) and satellite lesions and micro-Koebner phenomenon (p < .001) were associated with active vitiligo while perifollicular repigmentation (p < .001) was associated with stabilizing and repigmenting vitiligo. Satellite lesions and micro-Koebner's phenomena were suggestive of unstable disease irrespective of site of target lesion, while perifollicular repigmentation was suggestive of stabilized/repigmenting disease only at non-acral sites. We found sequential dermoscopy to be useful to assess disease activity and potential for repigmentation in localized vitiligo.</description><subject>Dermoscopy - methods</subject><subject>Health services</subject><subject>Humans</subject><subject>Lesions</subject><subject>Medical treatment</subject><subject>Observational studies</subject><subject>Patients</subject><subject>Prospective Studies</subject><subject>Skin diseases</subject><subject>Vitiligo</subject><subject>Vitiligo - pathology</subject><issn>1755-1471</issn><issn>1755-148X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkc1u1DAUhS0EoqWw4QHQldggpCl2_DdhV5VfqRIbkNhFjnNDXSVx8HWmypvyOHimnS4Q3tjX_nSOdQ5jLwU_F2W9m_2YzoXkpn7EToXVeiPU9ufjh7MVJ-wZ0Q3nhutaPmUn0ghRcatP2Z8LmFOkGX0OO4TYEqadyyFObgDKS7dCjkD4e8EpBzcMK3SYMY1hQsjXWKY0RvJxDh56dHlJSBB72IUchvArgps6CJnAEUUfDtJwG_I1dIHQEYLbW4e8QphgLu_FqChMMGIXfPlFTkV2LLfv4cPRbD3I_k_h6PucPendQPjifj9jPz59_H75ZXP17fPXy4urja-syhsr6l5oaWollDMcVdV62zorjDVaCe15X9fcc8VR1rpCaaTvClAJV7XYbuUZe3OnW2IsIVFuxkAeh8FNGBdqKiu0UrI2qqCv_0Fv4pJK0HtKb2tjtsoU6u0d5UsvlLBv5hRGl9ZG8Gbfd7Pvuzn0XeBX95JLW_J6QI8Fy7_c0qxN</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Gupta, Priyansh</creator><creator>Vinay, Keshavamurthy</creator><creator>Bishnoi, Anuradha</creator><creator>Kumaran, Muthu Sendhil</creator><creator>Parsad, Davinder</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6323-4988</orcidid></search><sort><creationdate>202301</creationdate><title>A prospective observational study to sequentially determine the dermoscopic features of vitiligo and its association with disease activity in patients on medical treatment: Dermoscopy and disease activity in vitiligo</title><author>Gupta, Priyansh ; Vinay, Keshavamurthy ; Bishnoi, Anuradha ; Kumaran, Muthu Sendhil ; Parsad, Davinder</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-719f15369414a60e42bc7ba716765415c0f990c040e3952e363cd7ba21a2beb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Dermoscopy - methods</topic><topic>Health services</topic><topic>Humans</topic><topic>Lesions</topic><topic>Medical treatment</topic><topic>Observational studies</topic><topic>Patients</topic><topic>Prospective Studies</topic><topic>Skin diseases</topic><topic>Vitiligo</topic><topic>Vitiligo - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gupta, Priyansh</creatorcontrib><creatorcontrib>Vinay, Keshavamurthy</creatorcontrib><creatorcontrib>Bishnoi, Anuradha</creatorcontrib><creatorcontrib>Kumaran, Muthu Sendhil</creatorcontrib><creatorcontrib>Parsad, Davinder</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Pigment cell and melanoma research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gupta, Priyansh</au><au>Vinay, Keshavamurthy</au><au>Bishnoi, Anuradha</au><au>Kumaran, Muthu Sendhil</au><au>Parsad, Davinder</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective observational study to sequentially determine the dermoscopic features of vitiligo and its association with disease activity in patients on medical treatment: Dermoscopy and disease activity in vitiligo</atitle><jtitle>Pigment cell and melanoma research</jtitle><addtitle>Pigment Cell Melanoma Res</addtitle><date>2023-01</date><risdate>2023</risdate><volume>36</volume><issue>1</issue><spage>33</spage><epage>41</epage><pages>33-41</pages><issn>1755-1471</issn><eissn>1755-148X</eissn><abstract>Prospective data on correlation between dermoscopic features of vitiligo and disease activity are scarce. This study was conducted to sequentially determine the dermoscopic features of vitiligo and to evaluate their association with disease activity. A cohort of 30 patients with 60 active vitiligo patches on medical therapy was subjected to sequential clinical and dermoscopic examination at four weekly intervals till 16 weeks. Disease activity at each visit was assessed using serial clinical photographs and modified vitiligo activity severity index. The dermoscopic images were merged and analysed for a predefined set of dermoscopic parameters by two blinded dermatologists. Paired analysis of dermoscopic features was done between baseline, and stabilized vitiligo patches at 12 and 16 weeks. Pigment network changes (absent and reduced pigment network, p < .001), perifollicular depigmentation (p = .02), ill-defined margins (p = .04) and satellite lesions and micro-Koebner phenomenon (p < .001) were associated with active vitiligo while perifollicular repigmentation (p < .001) was associated with stabilizing and repigmenting vitiligo. Satellite lesions and micro-Koebner's phenomena were suggestive of unstable disease irrespective of site of target lesion, while perifollicular repigmentation was suggestive of stabilized/repigmenting disease only at non-acral sites. We found sequential dermoscopy to be useful to assess disease activity and potential for repigmentation in localized vitiligo.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>36112075</pmid><doi>10.1111/pcmr.13069</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6323-4988</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Dermoscopy - methods Health services Humans Lesions Medical treatment Observational studies Patients Prospective Studies Skin diseases Vitiligo Vitiligo - pathology |
| title | A prospective observational study to sequentially determine the dermoscopic features of vitiligo and its association with disease activity in patients on medical treatment: Dermoscopy and disease activity in vitiligo |
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