Decidual dendritic cells 10 and CD4+CD25+FOXP3 regulatory T cell in preeclampsia and their correlation with nutritional factors in pathomechanism of immune rejection in pregnancy
Immune intolerance is thought to be the underlying cause of immune rejection to fetus in preeclampsia. Decidual dendritic cell-10 (DC-10) and T regulator cell (Treg) play important role to create tolerogenic environment during pregnancy. However, their roles on the specific pathomechanism of preecla...
Gespeichert in:
| Veröffentlicht in: | Journal of reproductive immunology 2022-12, Vol.154, p.103746-103746, Article 103746 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 103746 |
|---|---|
| container_issue | |
| container_start_page | 103746 |
| container_title | Journal of reproductive immunology |
| container_volume | 154 |
| creator | Silalahi, Eva Roria Wibowo, Noroyono Prasmusinto, Damar Djuwita, Ratna Rengganis, Iris Mose, Johanes C. |
| description | Immune intolerance is thought to be the underlying cause of immune rejection to fetus in preeclampsia. Decidual dendritic cell-10 (DC-10) and T regulator cell (Treg) play important role to create tolerogenic environment during pregnancy. However, their roles on the specific pathomechanism of preeclampsia along with various nutritional factors have not been widely studied.
To determine the number of DC-10 and Treg in preeclampsia and their correlations with decidual nutritional factors.
This was a cross-sectional study among early onset preeclampsia (EOPE), late onset preeclampsia (LOPE), and normotensive (NT) pregnancies. Decidual specimens were obtained by curettage after caesarean section. The number of DC-10 and Treg cells were counted using flow cytometry. The levels of nutritional factors (zinc, retinol, all-trans retinoic acid, vitamin D) were determined using ICP-MS and LC-MS method.
A total of 14 subjects for each group were included in the study. The DC-10 was significantly lower in both EOPE and LOPE compared to NT (p |
| doi_str_mv | 10.1016/j.jri.2022.103746 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2715442481</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165037822002753</els_id><sourcerecordid>2715442481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c283t-4b8da5c8c69ce0e198e84f131f3af2145b84af2769afbcf80efb94d3cbcb2d6e3</originalsourceid><addsrcrecordid>eNp9kc1u3CAUhVHVqJmkfYBuKpaVIk8AYxurq2qm-ZEipYtU6g5huGSwbJiC3Wpeq09YZpx22RWg-51zdDkIvadkTQmtr_t1H92aEcbyu2x4_QqtqGhY0dSkfI1WmamKPBDn6CKlnhDakJa-QedlTYngjK3Q7y1oZ2Y1YAPeRDc5jTUMQ8KUYOUN3mz51WbLqqubx-9fSxzheR7UFOIBP51A7DzeRwA9qHGfnDqJph24iHWIETLsgse_3LTDfp6OCcHnOKt0dkknuZp2YQS9U96lEQeL3TjOHnJYD_okX0KevfL68BadWTUkePdyXqJvN1-eNnfFw-Pt_ebzQ6GZKKeCd8KoSgtdtxoI0FaA4JaW1JbKMsqrTvB8aepW2U5bQcB2LTel7nTHTA3lJfq4-O5j-DFDmuTo0nFl5SHMSbKGVpwzLmhG6YLqGFKKYOU-ulHFg6REHquSvcxVyWNVcqkqaz682M_dCOaf4m83Gfi0AJCX_OkgyqQdeA3Gxfwt0gT3H_s_2PWnfA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2715442481</pqid></control><display><type>article</type><title>Decidual dendritic cells 10 and CD4+CD25+FOXP3 regulatory T cell in preeclampsia and their correlation with nutritional factors in pathomechanism of immune rejection in pregnancy</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Silalahi, Eva Roria ; Wibowo, Noroyono ; Prasmusinto, Damar ; Djuwita, Ratna ; Rengganis, Iris ; Mose, Johanes C.</creator><creatorcontrib>Silalahi, Eva Roria ; Wibowo, Noroyono ; Prasmusinto, Damar ; Djuwita, Ratna ; Rengganis, Iris ; Mose, Johanes C.</creatorcontrib><description>Immune intolerance is thought to be the underlying cause of immune rejection to fetus in preeclampsia. Decidual dendritic cell-10 (DC-10) and T regulator cell (Treg) play important role to create tolerogenic environment during pregnancy. However, their roles on the specific pathomechanism of preeclampsia along with various nutritional factors have not been widely studied.
To determine the number of DC-10 and Treg in preeclampsia and their correlations with decidual nutritional factors.
This was a cross-sectional study among early onset preeclampsia (EOPE), late onset preeclampsia (LOPE), and normotensive (NT) pregnancies. Decidual specimens were obtained by curettage after caesarean section. The number of DC-10 and Treg cells were counted using flow cytometry. The levels of nutritional factors (zinc, retinol, all-trans retinoic acid, vitamin D) were determined using ICP-MS and LC-MS method.
A total of 14 subjects for each group were included in the study. The DC-10 was significantly lower in both EOPE and LOPE compared to NT (p < 0.001). Treg cells were significantly higher in EOPE compare to NT (p = 0.015). There was a moderate correlation between zinc level and DC-10 (p = 0.011) and a strong correlation between retinol level and DC-10 (p = 0.002) in the NT group. A moderate correlation was found between vitamin D level and Treg cells in the NT group (p = 0.026).
There was a lower number of DC-10 and higher number of Treg cells in early preeclampsia. There was no correlation between DC-10 and Treg number with decidual nutritional factors in preeclampsia.
•Immune intolerance during placentation plays a significant role in the pathomechanism of preeclampsia.•Chronic inflammatory response on pregnancy with preeclampsia has created significant changes since decidualization.•There are no correlation between various nutritional factors and tolerogenic factors in pregnancy with preeclampsia.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/j.jri.2022.103746</identifier><identifier>PMID: 36108422</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Cesarean Section ; Cross-Sectional Studies ; Dendritic cell 10 ; Dendritic Cells ; Female ; Forkhead Transcription Factors ; Humans ; Pre-Eclampsia ; Preeclampsia ; Pregnancy ; Regulatory T cell ; T-Lymphocytes, Regulatory ; Vitamin A ; Vitamin D ; Zinc</subject><ispartof>Journal of reproductive immunology, 2022-12, Vol.154, p.103746-103746, Article 103746</ispartof><rights>2022 Elsevier B.V.</rights><rights>Copyright © 2022 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c283t-4b8da5c8c69ce0e198e84f131f3af2145b84af2769afbcf80efb94d3cbcb2d6e3</citedby><cites>FETCH-LOGICAL-c283t-4b8da5c8c69ce0e198e84f131f3af2145b84af2769afbcf80efb94d3cbcb2d6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jri.2022.103746$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,782,786,3554,27933,27934,46004</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36108422$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silalahi, Eva Roria</creatorcontrib><creatorcontrib>Wibowo, Noroyono</creatorcontrib><creatorcontrib>Prasmusinto, Damar</creatorcontrib><creatorcontrib>Djuwita, Ratna</creatorcontrib><creatorcontrib>Rengganis, Iris</creatorcontrib><creatorcontrib>Mose, Johanes C.</creatorcontrib><title>Decidual dendritic cells 10 and CD4+CD25+FOXP3 regulatory T cell in preeclampsia and their correlation with nutritional factors in pathomechanism of immune rejection in pregnancy</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>Immune intolerance is thought to be the underlying cause of immune rejection to fetus in preeclampsia. Decidual dendritic cell-10 (DC-10) and T regulator cell (Treg) play important role to create tolerogenic environment during pregnancy. However, their roles on the specific pathomechanism of preeclampsia along with various nutritional factors have not been widely studied.
To determine the number of DC-10 and Treg in preeclampsia and their correlations with decidual nutritional factors.
This was a cross-sectional study among early onset preeclampsia (EOPE), late onset preeclampsia (LOPE), and normotensive (NT) pregnancies. Decidual specimens were obtained by curettage after caesarean section. The number of DC-10 and Treg cells were counted using flow cytometry. The levels of nutritional factors (zinc, retinol, all-trans retinoic acid, vitamin D) were determined using ICP-MS and LC-MS method.
A total of 14 subjects for each group were included in the study. The DC-10 was significantly lower in both EOPE and LOPE compared to NT (p < 0.001). Treg cells were significantly higher in EOPE compare to NT (p = 0.015). There was a moderate correlation between zinc level and DC-10 (p = 0.011) and a strong correlation between retinol level and DC-10 (p = 0.002) in the NT group. A moderate correlation was found between vitamin D level and Treg cells in the NT group (p = 0.026).
There was a lower number of DC-10 and higher number of Treg cells in early preeclampsia. There was no correlation between DC-10 and Treg number with decidual nutritional factors in preeclampsia.
•Immune intolerance during placentation plays a significant role in the pathomechanism of preeclampsia.•Chronic inflammatory response on pregnancy with preeclampsia has created significant changes since decidualization.•There are no correlation between various nutritional factors and tolerogenic factors in pregnancy with preeclampsia.</description><subject>Cesarean Section</subject><subject>Cross-Sectional Studies</subject><subject>Dendritic cell 10</subject><subject>Dendritic Cells</subject><subject>Female</subject><subject>Forkhead Transcription Factors</subject><subject>Humans</subject><subject>Pre-Eclampsia</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>Regulatory T cell</subject><subject>T-Lymphocytes, Regulatory</subject><subject>Vitamin A</subject><subject>Vitamin D</subject><subject>Zinc</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u3CAUhVHVqJmkfYBuKpaVIk8AYxurq2qm-ZEipYtU6g5huGSwbJiC3Wpeq09YZpx22RWg-51zdDkIvadkTQmtr_t1H92aEcbyu2x4_QqtqGhY0dSkfI1WmamKPBDn6CKlnhDakJa-QedlTYngjK3Q7y1oZ2Y1YAPeRDc5jTUMQ8KUYOUN3mz51WbLqqubx-9fSxzheR7UFOIBP51A7DzeRwA9qHGfnDqJph24iHWIETLsgse_3LTDfp6OCcHnOKt0dkknuZp2YQS9U96lEQeL3TjOHnJYD_okX0KevfL68BadWTUkePdyXqJvN1-eNnfFw-Pt_ebzQ6GZKKeCd8KoSgtdtxoI0FaA4JaW1JbKMsqrTvB8aepW2U5bQcB2LTel7nTHTA3lJfq4-O5j-DFDmuTo0nFl5SHMSbKGVpwzLmhG6YLqGFKKYOU-ulHFg6REHquSvcxVyWNVcqkqaz682M_dCOaf4m83Gfi0AJCX_OkgyqQdeA3Gxfwt0gT3H_s_2PWnfA</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Silalahi, Eva Roria</creator><creator>Wibowo, Noroyono</creator><creator>Prasmusinto, Damar</creator><creator>Djuwita, Ratna</creator><creator>Rengganis, Iris</creator><creator>Mose, Johanes C.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202212</creationdate><title>Decidual dendritic cells 10 and CD4+CD25+FOXP3 regulatory T cell in preeclampsia and their correlation with nutritional factors in pathomechanism of immune rejection in pregnancy</title><author>Silalahi, Eva Roria ; Wibowo, Noroyono ; Prasmusinto, Damar ; Djuwita, Ratna ; Rengganis, Iris ; Mose, Johanes C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c283t-4b8da5c8c69ce0e198e84f131f3af2145b84af2769afbcf80efb94d3cbcb2d6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cesarean Section</topic><topic>Cross-Sectional Studies</topic><topic>Dendritic cell 10</topic><topic>Dendritic Cells</topic><topic>Female</topic><topic>Forkhead Transcription Factors</topic><topic>Humans</topic><topic>Pre-Eclampsia</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>Regulatory T cell</topic><topic>T-Lymphocytes, Regulatory</topic><topic>Vitamin A</topic><topic>Vitamin D</topic><topic>Zinc</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silalahi, Eva Roria</creatorcontrib><creatorcontrib>Wibowo, Noroyono</creatorcontrib><creatorcontrib>Prasmusinto, Damar</creatorcontrib><creatorcontrib>Djuwita, Ratna</creatorcontrib><creatorcontrib>Rengganis, Iris</creatorcontrib><creatorcontrib>Mose, Johanes C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silalahi, Eva Roria</au><au>Wibowo, Noroyono</au><au>Prasmusinto, Damar</au><au>Djuwita, Ratna</au><au>Rengganis, Iris</au><au>Mose, Johanes C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decidual dendritic cells 10 and CD4+CD25+FOXP3 regulatory T cell in preeclampsia and their correlation with nutritional factors in pathomechanism of immune rejection in pregnancy</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>2022-12</date><risdate>2022</risdate><volume>154</volume><spage>103746</spage><epage>103746</epage><pages>103746-103746</pages><artnum>103746</artnum><issn>0165-0378</issn><eissn>1872-7603</eissn><abstract>Immune intolerance is thought to be the underlying cause of immune rejection to fetus in preeclampsia. Decidual dendritic cell-10 (DC-10) and T regulator cell (Treg) play important role to create tolerogenic environment during pregnancy. However, their roles on the specific pathomechanism of preeclampsia along with various nutritional factors have not been widely studied.
To determine the number of DC-10 and Treg in preeclampsia and their correlations with decidual nutritional factors.
This was a cross-sectional study among early onset preeclampsia (EOPE), late onset preeclampsia (LOPE), and normotensive (NT) pregnancies. Decidual specimens were obtained by curettage after caesarean section. The number of DC-10 and Treg cells were counted using flow cytometry. The levels of nutritional factors (zinc, retinol, all-trans retinoic acid, vitamin D) were determined using ICP-MS and LC-MS method.
A total of 14 subjects for each group were included in the study. The DC-10 was significantly lower in both EOPE and LOPE compared to NT (p < 0.001). Treg cells were significantly higher in EOPE compare to NT (p = 0.015). There was a moderate correlation between zinc level and DC-10 (p = 0.011) and a strong correlation between retinol level and DC-10 (p = 0.002) in the NT group. A moderate correlation was found between vitamin D level and Treg cells in the NT group (p = 0.026).
There was a lower number of DC-10 and higher number of Treg cells in early preeclampsia. There was no correlation between DC-10 and Treg number with decidual nutritional factors in preeclampsia.
•Immune intolerance during placentation plays a significant role in the pathomechanism of preeclampsia.•Chronic inflammatory response on pregnancy with preeclampsia has created significant changes since decidualization.•There are no correlation between various nutritional factors and tolerogenic factors in pregnancy with preeclampsia.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>36108422</pmid><doi>10.1016/j.jri.2022.103746</doi><tpages>1</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0378 |
| ispartof | Journal of reproductive immunology, 2022-12, Vol.154, p.103746-103746, Article 103746 |
| issn | 0165-0378 1872-7603 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2715442481 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Cesarean Section Cross-Sectional Studies Dendritic cell 10 Dendritic Cells Female Forkhead Transcription Factors Humans Pre-Eclampsia Preeclampsia Pregnancy Regulatory T cell T-Lymphocytes, Regulatory Vitamin A Vitamin D Zinc |
| title | Decidual dendritic cells 10 and CD4+CD25+FOXP3 regulatory T cell in preeclampsia and their correlation with nutritional factors in pathomechanism of immune rejection in pregnancy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-03T02%3A52%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Decidual%20dendritic%20cells%2010%20and%20CD4+CD25+FOXP3%20regulatory%20T%20cell%20in%20preeclampsia%20and%20their%20correlation%20with%20nutritional%20factors%20in%20pathomechanism%20of%20immune%20rejection%20in%20pregnancy&rft.jtitle=Journal%20of%20reproductive%20immunology&rft.au=Silalahi,%20Eva%20Roria&rft.date=2022-12&rft.volume=154&rft.spage=103746&rft.epage=103746&rft.pages=103746-103746&rft.artnum=103746&rft.issn=0165-0378&rft.eissn=1872-7603&rft_id=info:doi/10.1016/j.jri.2022.103746&rft_dat=%3Cproquest_cross%3E2715442481%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2715442481&rft_id=info:pmid/36108422&rft_els_id=S0165037822002753&rfr_iscdi=true |