Ex Vivo Expansion of Phenotypic and Transcriptomic Chronic Myeloid Leukemia Stem Cells

•A means to expand leukemic stem cells from murine CML where they phenocopy their primary HSCs is described.•Both transcriptional and functional similarities to primary LSCs exist that lead to identification of targetable pathways, replicating other's findings and suggesting additional pathways...

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Veröffentlicht in:	Experimental hematology 2022-11, Vol.115, p.1-13
Hauptverfasser:	Patel, Sweta B., Kuznetsova, Valeriya, Matkins, Victoria R., Franceski, Alana M., Bassal, Mahmoud A., Welner, Robert S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Mice Neoplastic Stem Cells - metabolism Transcriptome Transforming Growth Factor beta - metabolism
Online-Zugang:	Volltext
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