zVAD alleviates experimental autoimmune hepatitis in mice by increasing the sensitivity of macrophage to TNFR1-dependent necroptosis

Autoimmune hepatitis (AIH) is characterized by hepatocyte destruction, leading to lymphocyte and macrophage accumulation in the liver. Macrophages are key drivers of AIH. A membrane-permeable pan-caspase inhibitor, Z-Val-Ala-DL-Asp-fluoromethylketone (zVAD), induces macrophage necroptosis in respons...

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Veröffentlicht in:	Journal of autoimmunity 2022-12, Vol.133, p.102904-102904, Article 102904
Hauptverfasser:	Li, Xuehui, Zhang, Yongting, Wang, Jinping, Li, Yuyu, Wang, Yuchong, Shi, Fan, Hong, Liang, Li, Lanjuan, Diao, Hongyan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemical and Drug Induced Liver Injury, Chronic Disease Models, Animal Hepatitis, Autoimmune - therapy Interleukin-10 Liver injury Macrophages Mice Necroptosis Oligopeptides - therapeutic use TNFR1 zVAD
Online-Zugang:	Volltext
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