Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis
Unlike regular environmental pollutants, microplastics cannot dissolve in liquids. Physical contact of microplastic (MPs) with tissue can damage tissue structure, and it is unclear how this physical secondary injury affects brain tissue. Through CTD database analysis, it was determined that cerebral...
Gespeichert in:
Veröffentlicht in: | Chemico-biological interactions 2022-11, Vol.367, p.110180-110180, Article 110180 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 110180 |
---|---|
container_issue | |
container_start_page | 110180 |
container_title | Chemico-biological interactions |
container_volume | 367 |
creator | Yin, Kai Lu, Hongmin Zhang, Yue Hou, Lulu Meng, Xin Li, Junbo Zhao, Hongjing Xing, Mingwei |
description | Unlike regular environmental pollutants, microplastics cannot dissolve in liquids. Physical contact of microplastic (MPs) with tissue can damage tissue structure, and it is unclear how this physical secondary injury affects brain tissue. Through CTD database analysis, it was determined that cerebral ischemia may be one of the main ways of brain tissue damage caused by MPs, and inflammatory response may play a key role in it. In the present study, PS-MPs (L-PS group:1 mg/L, M − PS group:10 mg/L, H-PS group: 100 mg/L in water) were assessed to brain tissue damage in chicken after six weeks of continuous exposure. Exposure to PS-MPs caused cerebral hemorrhage as well as generation of microthrombi and loss of Purkinje cells. Intracerebral hemorrhage caused a strong infiltration of inflammatory cells and activated the ASC-NLRP3-GSDMD signaling pathway to induce pyroptosis. Disruption of mitochondrial dynamics by PS-MPs exposure disrupts mitochondrial function and activates AMPK signaling. In conclusion, this study explored the mechanism regulation of subsequent brain injury from the perspective of physical injury (cerebral hemorrhage) of PS-MPs. To provide a reference for elucidating the neurotoxicity induced by microplastic exposure.
[Display omitted]
•Exposure to PS-MPs caused hemorrhage in chicken brain tissue.•PS-MPs disrupt mitochondrial dynamic homeostasis, leading to dysfunction.•In response to mitochondrial damage, the AMPK signaling pathway is activated. |
doi_str_mv | 10.1016/j.cbi.2022.110180 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2715440453</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0009279722003854</els_id><sourcerecordid>2715440453</sourcerecordid><originalsourceid>FETCH-LOGICAL-c330t-efe7ff15174982c5a661812dcc63a07b3730e7b17199549a52e5aaf4e9e0bd783</originalsourceid><addsrcrecordid>eNp9kE1r3DAQhkVpoNskPyA3HXvxRpI_ZNNTWdokEMghyVmM5XF2FltyJbllf0D_d7VszjkN7_C8A_MwdiPFVgrZ3B62tqetEkptZV604hPbyFarQuu2-cw2QoiuULrTX9jXGA85ClWJDfv3jNa7AcKR9wHIcXKHNQcYEwa--OkY0zGgQz6TDX6ZICayBblhtThkOgWwGDCXJ77H2YewhzfkFDnE6C1BythfSvvMjhPMMyTyjoMb-HLMB5OPFK_YxQhTxOv3eclef_182d0Xj093D7sfj4UtS5EKHFGPo6ylrrpW2RqaRrZSDdY2JQjdl7oUqHupZdfVVQe1whpgrLBD0Q-6LS_Zt_PdJfjfK8ZkZooWpwkc-jUapWVdVaKqy4zKM5q_jjHgaJZAc_ZkpDAn5eZgsnJzUm7OynPn-7mD-Yc_hMFES-iyKApokxk8fdD-D1JvjR0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2715440453</pqid></control><display><type>article</type><title>Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis</title><source>Access via ScienceDirect (Elsevier)</source><creator>Yin, Kai ; Lu, Hongmin ; Zhang, Yue ; Hou, Lulu ; Meng, Xin ; Li, Junbo ; Zhao, Hongjing ; Xing, Mingwei</creator><creatorcontrib>Yin, Kai ; Lu, Hongmin ; Zhang, Yue ; Hou, Lulu ; Meng, Xin ; Li, Junbo ; Zhao, Hongjing ; Xing, Mingwei</creatorcontrib><description>Unlike regular environmental pollutants, microplastics cannot dissolve in liquids. Physical contact of microplastic (MPs) with tissue can damage tissue structure, and it is unclear how this physical secondary injury affects brain tissue. Through CTD database analysis, it was determined that cerebral ischemia may be one of the main ways of brain tissue damage caused by MPs, and inflammatory response may play a key role in it. In the present study, PS-MPs (L-PS group:1 mg/L, M − PS group:10 mg/L, H-PS group: 100 mg/L in water) were assessed to brain tissue damage in chicken after six weeks of continuous exposure. Exposure to PS-MPs caused cerebral hemorrhage as well as generation of microthrombi and loss of Purkinje cells. Intracerebral hemorrhage caused a strong infiltration of inflammatory cells and activated the ASC-NLRP3-GSDMD signaling pathway to induce pyroptosis. Disruption of mitochondrial dynamics by PS-MPs exposure disrupts mitochondrial function and activates AMPK signaling. In conclusion, this study explored the mechanism regulation of subsequent brain injury from the perspective of physical injury (cerebral hemorrhage) of PS-MPs. To provide a reference for elucidating the neurotoxicity induced by microplastic exposure.
[Display omitted]
•Exposure to PS-MPs caused hemorrhage in chicken brain tissue.•PS-MPs disrupt mitochondrial dynamic homeostasis, leading to dysfunction.•In response to mitochondrial damage, the AMPK signaling pathway is activated.</description><identifier>ISSN: 0009-2797</identifier><identifier>EISSN: 1872-7786</identifier><identifier>DOI: 10.1016/j.cbi.2022.110180</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>CTD ; Intracerebral hemorrhage ; Microplastic ; Mitochondrial ; Pyroptosis</subject><ispartof>Chemico-biological interactions, 2022-11, Vol.367, p.110180-110180, Article 110180</ispartof><rights>2022 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c330t-efe7ff15174982c5a661812dcc63a07b3730e7b17199549a52e5aaf4e9e0bd783</citedby><cites>FETCH-LOGICAL-c330t-efe7ff15174982c5a661812dcc63a07b3730e7b17199549a52e5aaf4e9e0bd783</cites><orcidid>0000-0003-1636-897X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.cbi.2022.110180$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Yin, Kai</creatorcontrib><creatorcontrib>Lu, Hongmin</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Hou, Lulu</creatorcontrib><creatorcontrib>Meng, Xin</creatorcontrib><creatorcontrib>Li, Junbo</creatorcontrib><creatorcontrib>Zhao, Hongjing</creatorcontrib><creatorcontrib>Xing, Mingwei</creatorcontrib><title>Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis</title><title>Chemico-biological interactions</title><description>Unlike regular environmental pollutants, microplastics cannot dissolve in liquids. Physical contact of microplastic (MPs) with tissue can damage tissue structure, and it is unclear how this physical secondary injury affects brain tissue. Through CTD database analysis, it was determined that cerebral ischemia may be one of the main ways of brain tissue damage caused by MPs, and inflammatory response may play a key role in it. In the present study, PS-MPs (L-PS group:1 mg/L, M − PS group:10 mg/L, H-PS group: 100 mg/L in water) were assessed to brain tissue damage in chicken after six weeks of continuous exposure. Exposure to PS-MPs caused cerebral hemorrhage as well as generation of microthrombi and loss of Purkinje cells. Intracerebral hemorrhage caused a strong infiltration of inflammatory cells and activated the ASC-NLRP3-GSDMD signaling pathway to induce pyroptosis. Disruption of mitochondrial dynamics by PS-MPs exposure disrupts mitochondrial function and activates AMPK signaling. In conclusion, this study explored the mechanism regulation of subsequent brain injury from the perspective of physical injury (cerebral hemorrhage) of PS-MPs. To provide a reference for elucidating the neurotoxicity induced by microplastic exposure.
[Display omitted]
•Exposure to PS-MPs caused hemorrhage in chicken brain tissue.•PS-MPs disrupt mitochondrial dynamic homeostasis, leading to dysfunction.•In response to mitochondrial damage, the AMPK signaling pathway is activated.</description><subject>CTD</subject><subject>Intracerebral hemorrhage</subject><subject>Microplastic</subject><subject>Mitochondrial</subject><subject>Pyroptosis</subject><issn>0009-2797</issn><issn>1872-7786</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kE1r3DAQhkVpoNskPyA3HXvxRpI_ZNNTWdokEMghyVmM5XF2FltyJbllf0D_d7VszjkN7_C8A_MwdiPFVgrZ3B62tqetEkptZV604hPbyFarQuu2-cw2QoiuULrTX9jXGA85ClWJDfv3jNa7AcKR9wHIcXKHNQcYEwa--OkY0zGgQz6TDX6ZICayBblhtThkOgWwGDCXJ77H2YewhzfkFDnE6C1BythfSvvMjhPMMyTyjoMb-HLMB5OPFK_YxQhTxOv3eclef_182d0Xj093D7sfj4UtS5EKHFGPo6ylrrpW2RqaRrZSDdY2JQjdl7oUqHupZdfVVQe1whpgrLBD0Q-6LS_Zt_PdJfjfK8ZkZooWpwkc-jUapWVdVaKqy4zKM5q_jjHgaJZAc_ZkpDAn5eZgsnJzUm7OynPn-7mD-Yc_hMFES-iyKApokxk8fdD-D1JvjR0</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Yin, Kai</creator><creator>Lu, Hongmin</creator><creator>Zhang, Yue</creator><creator>Hou, Lulu</creator><creator>Meng, Xin</creator><creator>Li, Junbo</creator><creator>Zhao, Hongjing</creator><creator>Xing, Mingwei</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1636-897X</orcidid></search><sort><creationdate>20221101</creationdate><title>Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis</title><author>Yin, Kai ; Lu, Hongmin ; Zhang, Yue ; Hou, Lulu ; Meng, Xin ; Li, Junbo ; Zhao, Hongjing ; Xing, Mingwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c330t-efe7ff15174982c5a661812dcc63a07b3730e7b17199549a52e5aaf4e9e0bd783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>CTD</topic><topic>Intracerebral hemorrhage</topic><topic>Microplastic</topic><topic>Mitochondrial</topic><topic>Pyroptosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Kai</creatorcontrib><creatorcontrib>Lu, Hongmin</creatorcontrib><creatorcontrib>Zhang, Yue</creatorcontrib><creatorcontrib>Hou, Lulu</creatorcontrib><creatorcontrib>Meng, Xin</creatorcontrib><creatorcontrib>Li, Junbo</creatorcontrib><creatorcontrib>Zhao, Hongjing</creatorcontrib><creatorcontrib>Xing, Mingwei</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Chemico-biological interactions</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Kai</au><au>Lu, Hongmin</au><au>Zhang, Yue</au><au>Hou, Lulu</au><au>Meng, Xin</au><au>Li, Junbo</au><au>Zhao, Hongjing</au><au>Xing, Mingwei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis</atitle><jtitle>Chemico-biological interactions</jtitle><date>2022-11-01</date><risdate>2022</risdate><volume>367</volume><spage>110180</spage><epage>110180</epage><pages>110180-110180</pages><artnum>110180</artnum><issn>0009-2797</issn><eissn>1872-7786</eissn><abstract>Unlike regular environmental pollutants, microplastics cannot dissolve in liquids. Physical contact of microplastic (MPs) with tissue can damage tissue structure, and it is unclear how this physical secondary injury affects brain tissue. Through CTD database analysis, it was determined that cerebral ischemia may be one of the main ways of brain tissue damage caused by MPs, and inflammatory response may play a key role in it. In the present study, PS-MPs (L-PS group:1 mg/L, M − PS group:10 mg/L, H-PS group: 100 mg/L in water) were assessed to brain tissue damage in chicken after six weeks of continuous exposure. Exposure to PS-MPs caused cerebral hemorrhage as well as generation of microthrombi and loss of Purkinje cells. Intracerebral hemorrhage caused a strong infiltration of inflammatory cells and activated the ASC-NLRP3-GSDMD signaling pathway to induce pyroptosis. Disruption of mitochondrial dynamics by PS-MPs exposure disrupts mitochondrial function and activates AMPK signaling. In conclusion, this study explored the mechanism regulation of subsequent brain injury from the perspective of physical injury (cerebral hemorrhage) of PS-MPs. To provide a reference for elucidating the neurotoxicity induced by microplastic exposure.
[Display omitted]
•Exposure to PS-MPs caused hemorrhage in chicken brain tissue.•PS-MPs disrupt mitochondrial dynamic homeostasis, leading to dysfunction.•In response to mitochondrial damage, the AMPK signaling pathway is activated.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.cbi.2022.110180</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1636-897X</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0009-2797 |
ispartof | Chemico-biological interactions, 2022-11, Vol.367, p.110180-110180, Article 110180 |
issn | 0009-2797 1872-7786 |
language | eng |
recordid | cdi_proquest_miscellaneous_2715440453 |
source | Access via ScienceDirect (Elsevier) |
subjects | CTD Intracerebral hemorrhage Microplastic Mitochondrial Pyroptosis |
title | Secondary brain injury after polystyrene microplastic-induced intracerebral hemorrhage is associated with inflammation and pyroptosis |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T12%3A55%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Secondary%20brain%20injury%20after%20polystyrene%20microplastic-induced%20intracerebral%20hemorrhage%20is%20associated%20with%20inflammation%20and%20pyroptosis&rft.jtitle=Chemico-biological%20interactions&rft.au=Yin,%20Kai&rft.date=2022-11-01&rft.volume=367&rft.spage=110180&rft.epage=110180&rft.pages=110180-110180&rft.artnum=110180&rft.issn=0009-2797&rft.eissn=1872-7786&rft_id=info:doi/10.1016/j.cbi.2022.110180&rft_dat=%3Cproquest_cross%3E2715440453%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2715440453&rft_id=info:pmid/&rft_els_id=S0009279722003854&rfr_iscdi=true |