Type I interferon receptor signalling deficiency results in dysregulated innate immune responses to SARS‐CoV‐2 in mice

SARS‐CoV‐2 is a newly emerged coronavirus, causing the global pandemic of respiratory coronavirus disease (COVID‐19). The type I interferon (IFN) pathway is of particular importance for anti‐viral defense and recent studies identified that type I IFNs drive early inflammatory responses to SARS‐CoV‐2...

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Veröffentlicht in:	European journal of immunology 2022-11, Vol.52 (11), p.1768-1775
Hauptverfasser:	Ogger, Patricia P., Garcia Martín, Minerva, Michalaki, Christina, Zhou, Jie, Brown, Jonathan C., Du, Yue, Miah, Kamran M., Habib, Omar, Hyde, Stephen C., Gill, Deborah R., Barclay, Wendy S., Johansson, Cecilia
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Chemokines Coronaviruses COVID-19 COVID-19 - immunology Gene expression Immune response Immunity, Innate in vivo Infections Inflammation innate immune response Innate immunity Interferon Interferon Type I Leukocytes (neutrophilic) Mice Monocyte chemoattractant protein 1 Monocytes Myeloid cells Pandemics Receptor, Interferon alpha-beta - genetics SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Signal transduction type I IFN
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