Two-drug trick to target the brain blocks toxicity in the body
When combined, two drugs alter the activity of a protein complex called target of rapamycin complex 1 such that it is inhibited in the brain but not the body, enabling the treatment of brain tumours in mice without systemic toxicity. Brain-specific inhibition of the TORC1 protein complex.
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| Veröffentlicht in: | Nature (London) 2022-09, Vol.609 (7928), p.681-683 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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| Online-Zugang: | Volltext |
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| Zusammenfassung: | When combined, two drugs alter the activity of a protein complex called target of rapamycin complex 1 such that it is inhibited in the brain but not the body, enabling the treatment of brain tumours in mice without systemic toxicity.
Brain-specific inhibition of the TORC1 protein complex. |
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| ISSN: | 0028-0836 1476-4687 |
| DOI: | 10.1038/d41586-022-02892-5 |