Targeting the ATG5-ATG16L1 Protein–Protein Interaction with a Hydrocarbon-Stapled Peptide Derived from ATG16L1 for Autophagy Inhibition

Selective modulation of autophagy is a promising therapeutic strategy, especially for cancer treatment. However, the lack of specific autophagy inhibitors limits this strategy. The formation of the ATG12–ATG5–ATG16L1 complex is essential for targeting the ATG12–ATG5 conjugate to proper membranes and...

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Veröffentlicht in:	Journal of the American Chemical Society 2022-09, Vol.144 (38), p.17671-17679
Hauptverfasser:	Cui, Jin, Ogasawara, Yuta, Kurata, Ikuko, Matoba, Kazuaki, Fujioka, Yuko, Noda, Nobuo N., Shibasaki, Masakatsu, Watanabe, Takumi
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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