Cricopharyngeus Muscle Dysfunction and Hypopharyngeal Diverticula (e.g., Zenker): A Multicenter Study
Objective To describe demographics and imaging and compare findings and symptoms at presentation in a large cohort of persons with cricopharyngeus muscle dysfunction (CPMD) with and without hypopharyngeal diverticula. Methodology Prospective, multicenter cohort study of all individuals enrolled in t...
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| Veröffentlicht in: | The Laryngoscope 2023-06, Vol.133 (6), p.1349-1355 |
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| creator | Howell, Rebecca J. Ekbom, Dale Kasperbauer, Jan Tabangin, Meredith Altaye, Mekibib Wahab, Shaun Belafsky, Peter Allen, Jacqui Amin, Milan Bayan, Semirra Cervenka, Brian deSilva, Brad Dion, Greg Friedman, Aaron Fritz, Mark Giliberto, John Paul Guardiani, Elizabeth Harmon, Jeffrey Khosla, Sid Kim, Brandon Kuhn, Maggie Kwak, Paul Ma, Yue Madden, Lyndsay Matrka, Laura Mayerhoff, Ross Piraka, Cyrus Rosen, Clark Wilson, Keith Wright, Carter Young, Vyvy Yuen, Sonia Postma, Greg |
| description | Objective
To describe demographics and imaging and compare findings and symptoms at presentation in a large cohort of persons with cricopharyngeus muscle dysfunction (CPMD) with and without hypopharyngeal diverticula.
Methodology
Prospective, multicenter cohort study of all individuals enrolled in the Prospective OUtcomes of Cricopharyngeal Hypertonicity (POUCH) Collaborative. Patient survey, comorbidities, radiography, laryngoscopy findings, and patient‐reported outcome measures (e.g., Eating Assessment Tool [EAT‐10]) data were ed from a REDCap database and summarized using means, medians, percentages, and frequencies. Diagnostic categories were compared using analysis of variance.
Results
A total of 250 persons were included. The mean age (standard deviation [SD]) of the cohort was 69.0 (11.2). Forty‐two percent identified as female. Zenker diverticula (ZD) was diagnosed in 85.2%, 9.2% with CPMD without diverticula, 4.4% with a Killian Jamieson diverticula (KJD), and 1.2% traction‐type diverticula. There were no differences between diagnostic categories in regard to age, gender, and duration of symptoms (p = 0.25, 0.19, 0.45). The mean (SD) EAT‐10 score for each group was 17.1 (10.1) for ZD, 20.2 (9.3) for CPMD, and 10.3 (9.4) for KJD. Patients with isolated CPMD had significantly greater EAT‐10 scores compared to the other diagnostic groups (p = 0.03).
Conclusion
ZD is the most common, followed by CPMD without diverticula, KJD, and traction‐type. Patients with isolated obstructing CPMD may be more symptomatic than persons with ZD or KJD.
Level of Evidence
4 Laryngoscope, 133:1349–1355, 2023
This serves as the seminal work from the prospective, multicenter cohort study of all individuals enrolled in the Prospective OUtcomes of Cricopharyngeal Hypertonicity Surgery (POUCHS) Collaborative. Of the 250 persons enrolled, 85% had a Zenker diverticula (ZD), 9% had evidence of cricopharyngeus muscle dysfunction (CPMD) without diverticula and 4% had a Killian Jamieson diverticula (KJD). Patients with isolated CPMD appear to be more symptomatic than persons with ZD or KJD. |
| doi_str_mv | 10.1002/lary.30387 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2714392231</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2811166802</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3937-c921642dd47c8442255021cdb8dae8a52d98bede8becb50de32a33675688d9ab3</originalsourceid><addsrcrecordid>eNp9kE1P3DAQQK2qqCxLL_0BlaVeAJGtP-LE4bZaPqWtkGiRgIvl2LM01JssdgzKv8ewwIFDLzOHeXoaPYS-UTKhhLCfTvthwgmX5Sc0ooLTLK8q8RmN0pFnUrCrTbQVwh0htOSCfEGbvKCEsUqOEMx8Y7rV36RobyEG_CsG4wAfDmERW9M3XYt1a_HpsHqntMOHzQP4vjHRabwDk9vJPr6B9h_43QM8TQ6XbtD24PHvPtphG20stAvw9XWP0eXx0Z_ZaTY_PzmbTeeZ4RUvM1MxWuTM2rw0Ms8ZE4IwamwtrQapBbOVrMFCGqYWxAJnmvOiFIWUttI1H6OdtXflu_sIoVfLJhhwTrfQxaBYSXNeMcZpQn98QO-66Nv0nWKSUloUMtUbo701ZXwXgoeFWvlmmTIoStRzfPUcX73ET_D3V2Wsl2Df0bfaCaBr4LFxMPxHpebTi-u19AldF48N</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2811166802</pqid></control><display><type>article</type><title>Cricopharyngeus Muscle Dysfunction and Hypopharyngeal Diverticula (e.g., Zenker): A Multicenter Study</title><source>Wiley-Blackwell Journals</source><source>MEDLINE</source><creator>Howell, Rebecca J. ; Ekbom, Dale ; Kasperbauer, Jan ; Tabangin, Meredith ; Altaye, Mekibib ; Wahab, Shaun ; Belafsky, Peter ; Allen, Jacqui ; Amin, Milan ; Bayan, Semirra ; Cervenka, Brian ; deSilva, Brad ; Dion, Greg ; Friedman, Aaron ; Fritz, Mark ; Giliberto, John Paul ; Guardiani, Elizabeth ; Harmon, Jeffrey ; Khosla, Sid ; Kim, Brandon ; Kuhn, Maggie ; Kwak, Paul ; Ma, Yue ; Madden, Lyndsay ; Matrka, Laura ; Mayerhoff, Ross ; Piraka, Cyrus ; Rosen, Clark ; Wilson, Keith ; Wright, Carter ; Young, Vyvy ; Yuen, Sonia ; Postma, Greg</creator><creatorcontrib>Howell, Rebecca J. ; Ekbom, Dale ; Kasperbauer, Jan ; Tabangin, Meredith ; Altaye, Mekibib ; Wahab, Shaun ; Belafsky, Peter ; Allen, Jacqui ; Amin, Milan ; Bayan, Semirra ; Cervenka, Brian ; deSilva, Brad ; Dion, Greg ; Friedman, Aaron ; Fritz, Mark ; Giliberto, John Paul ; Guardiani, Elizabeth ; Harmon, Jeffrey ; Khosla, Sid ; Kim, Brandon ; Kuhn, Maggie ; Kwak, Paul ; Ma, Yue ; Madden, Lyndsay ; Matrka, Laura ; Mayerhoff, Ross ; Piraka, Cyrus ; Rosen, Clark ; Wilson, Keith ; Wright, Carter ; Young, Vyvy ; Yuen, Sonia ; Postma, Greg</creatorcontrib><description>Objective
To describe demographics and imaging and compare findings and symptoms at presentation in a large cohort of persons with cricopharyngeus muscle dysfunction (CPMD) with and without hypopharyngeal diverticula.
Methodology
Prospective, multicenter cohort study of all individuals enrolled in the Prospective OUtcomes of Cricopharyngeal Hypertonicity (POUCH) Collaborative. Patient survey, comorbidities, radiography, laryngoscopy findings, and patient‐reported outcome measures (e.g., Eating Assessment Tool [EAT‐10]) data were ed from a REDCap database and summarized using means, medians, percentages, and frequencies. Diagnostic categories were compared using analysis of variance.
Results
A total of 250 persons were included. The mean age (standard deviation [SD]) of the cohort was 69.0 (11.2). Forty‐two percent identified as female. Zenker diverticula (ZD) was diagnosed in 85.2%, 9.2% with CPMD without diverticula, 4.4% with a Killian Jamieson diverticula (KJD), and 1.2% traction‐type diverticula. There were no differences between diagnostic categories in regard to age, gender, and duration of symptoms (p = 0.25, 0.19, 0.45). The mean (SD) EAT‐10 score for each group was 17.1 (10.1) for ZD, 20.2 (9.3) for CPMD, and 10.3 (9.4) for KJD. Patients with isolated CPMD had significantly greater EAT‐10 scores compared to the other diagnostic groups (p = 0.03).
Conclusion
ZD is the most common, followed by CPMD without diverticula, KJD, and traction‐type. Patients with isolated obstructing CPMD may be more symptomatic than persons with ZD or KJD.
Level of Evidence
4 Laryngoscope, 133:1349–1355, 2023
This serves as the seminal work from the prospective, multicenter cohort study of all individuals enrolled in the Prospective OUtcomes of Cricopharyngeal Hypertonicity Surgery (POUCHS) Collaborative. Of the 250 persons enrolled, 85% had a Zenker diverticula (ZD), 9% had evidence of cricopharyngeus muscle dysfunction (CPMD) without diverticula and 4% had a Killian Jamieson diverticula (KJD). Patients with isolated CPMD appear to be more symptomatic than persons with ZD or KJD.</description><identifier>ISSN: 0023-852X</identifier><identifier>EISSN: 1531-4995</identifier><identifier>DOI: 10.1002/lary.30387</identifier><identifier>PMID: 36102298</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Cohort Studies ; CPMD ; cricopharyngeal bar ; cricopharyngeal dysfunction ; cricopharyngeus muscle dysfunction ; Dysphagia ; Esophageal Diseases ; Esophageal Sphincter, Upper ; Esophagus ; Female ; Humans ; hypopharyngeal diverticulum ; Killian Jamieson ; Laryngoscopy ; Muscular Diseases ; Otolaryngology ; Pharyngeal Diseases ; pharyngoesophageal dysphagia ; Prospective Studies ; Zenker ; Zenker Diverticulum - complications ; Zenker Diverticulum - surgery</subject><ispartof>The Laryngoscope, 2023-06, Vol.133 (6), p.1349-1355</ispartof><rights>2022 The Authors. published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.</rights><rights>2022 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc.</rights><rights>2022. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3937-c921642dd47c8442255021cdb8dae8a52d98bede8becb50de32a33675688d9ab3</citedby><cites>FETCH-LOGICAL-c3937-c921642dd47c8442255021cdb8dae8a52d98bede8becb50de32a33675688d9ab3</cites><orcidid>0000-0001-8770-8463 ; 0000-0002-5503-0325 ; 0000-0003-4300-5146 ; 0000-0003-2345-1157 ; 0000-0003-0288-2839</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flary.30387$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flary.30387$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36102298$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howell, Rebecca J.</creatorcontrib><creatorcontrib>Ekbom, Dale</creatorcontrib><creatorcontrib>Kasperbauer, Jan</creatorcontrib><creatorcontrib>Tabangin, Meredith</creatorcontrib><creatorcontrib>Altaye, Mekibib</creatorcontrib><creatorcontrib>Wahab, Shaun</creatorcontrib><creatorcontrib>Belafsky, Peter</creatorcontrib><creatorcontrib>Allen, Jacqui</creatorcontrib><creatorcontrib>Amin, Milan</creatorcontrib><creatorcontrib>Bayan, Semirra</creatorcontrib><creatorcontrib>Cervenka, Brian</creatorcontrib><creatorcontrib>deSilva, Brad</creatorcontrib><creatorcontrib>Dion, Greg</creatorcontrib><creatorcontrib>Friedman, Aaron</creatorcontrib><creatorcontrib>Fritz, Mark</creatorcontrib><creatorcontrib>Giliberto, John Paul</creatorcontrib><creatorcontrib>Guardiani, Elizabeth</creatorcontrib><creatorcontrib>Harmon, Jeffrey</creatorcontrib><creatorcontrib>Khosla, Sid</creatorcontrib><creatorcontrib>Kim, Brandon</creatorcontrib><creatorcontrib>Kuhn, Maggie</creatorcontrib><creatorcontrib>Kwak, Paul</creatorcontrib><creatorcontrib>Ma, Yue</creatorcontrib><creatorcontrib>Madden, Lyndsay</creatorcontrib><creatorcontrib>Matrka, Laura</creatorcontrib><creatorcontrib>Mayerhoff, Ross</creatorcontrib><creatorcontrib>Piraka, Cyrus</creatorcontrib><creatorcontrib>Rosen, Clark</creatorcontrib><creatorcontrib>Wilson, Keith</creatorcontrib><creatorcontrib>Wright, Carter</creatorcontrib><creatorcontrib>Young, Vyvy</creatorcontrib><creatorcontrib>Yuen, Sonia</creatorcontrib><creatorcontrib>Postma, Greg</creatorcontrib><title>Cricopharyngeus Muscle Dysfunction and Hypopharyngeal Diverticula (e.g., Zenker): A Multicenter Study</title><title>The Laryngoscope</title><addtitle>Laryngoscope</addtitle><description>Objective
To describe demographics and imaging and compare findings and symptoms at presentation in a large cohort of persons with cricopharyngeus muscle dysfunction (CPMD) with and without hypopharyngeal diverticula.
Methodology
Prospective, multicenter cohort study of all individuals enrolled in the Prospective OUtcomes of Cricopharyngeal Hypertonicity (POUCH) Collaborative. Patient survey, comorbidities, radiography, laryngoscopy findings, and patient‐reported outcome measures (e.g., Eating Assessment Tool [EAT‐10]) data were ed from a REDCap database and summarized using means, medians, percentages, and frequencies. Diagnostic categories were compared using analysis of variance.
Results
A total of 250 persons were included. The mean age (standard deviation [SD]) of the cohort was 69.0 (11.2). Forty‐two percent identified as female. Zenker diverticula (ZD) was diagnosed in 85.2%, 9.2% with CPMD without diverticula, 4.4% with a Killian Jamieson diverticula (KJD), and 1.2% traction‐type diverticula. There were no differences between diagnostic categories in regard to age, gender, and duration of symptoms (p = 0.25, 0.19, 0.45). The mean (SD) EAT‐10 score for each group was 17.1 (10.1) for ZD, 20.2 (9.3) for CPMD, and 10.3 (9.4) for KJD. Patients with isolated CPMD had significantly greater EAT‐10 scores compared to the other diagnostic groups (p = 0.03).
Conclusion
ZD is the most common, followed by CPMD without diverticula, KJD, and traction‐type. Patients with isolated obstructing CPMD may be more symptomatic than persons with ZD or KJD.
Level of Evidence
4 Laryngoscope, 133:1349–1355, 2023
This serves as the seminal work from the prospective, multicenter cohort study of all individuals enrolled in the Prospective OUtcomes of Cricopharyngeal Hypertonicity Surgery (POUCHS) Collaborative. Of the 250 persons enrolled, 85% had a Zenker diverticula (ZD), 9% had evidence of cricopharyngeus muscle dysfunction (CPMD) without diverticula and 4% had a Killian Jamieson diverticula (KJD). Patients with isolated CPMD appear to be more symptomatic than persons with ZD or KJD.</description><subject>Cohort Studies</subject><subject>CPMD</subject><subject>cricopharyngeal bar</subject><subject>cricopharyngeal dysfunction</subject><subject>cricopharyngeus muscle dysfunction</subject><subject>Dysphagia</subject><subject>Esophageal Diseases</subject><subject>Esophageal Sphincter, Upper</subject><subject>Esophagus</subject><subject>Female</subject><subject>Humans</subject><subject>hypopharyngeal diverticulum</subject><subject>Killian Jamieson</subject><subject>Laryngoscopy</subject><subject>Muscular Diseases</subject><subject>Otolaryngology</subject><subject>Pharyngeal Diseases</subject><subject>pharyngoesophageal dysphagia</subject><subject>Prospective Studies</subject><subject>Zenker</subject><subject>Zenker Diverticulum - complications</subject><subject>Zenker Diverticulum - surgery</subject><issn>0023-852X</issn><issn>1531-4995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNp9kE1P3DAQQK2qqCxLL_0BlaVeAJGtP-LE4bZaPqWtkGiRgIvl2LM01JssdgzKv8ewwIFDLzOHeXoaPYS-UTKhhLCfTvthwgmX5Sc0ooLTLK8q8RmN0pFnUrCrTbQVwh0htOSCfEGbvKCEsUqOEMx8Y7rV36RobyEG_CsG4wAfDmERW9M3XYt1a_HpsHqntMOHzQP4vjHRabwDk9vJPr6B9h_43QM8TQ6XbtD24PHvPtphG20stAvw9XWP0eXx0Z_ZaTY_PzmbTeeZ4RUvM1MxWuTM2rw0Ms8ZE4IwamwtrQapBbOVrMFCGqYWxAJnmvOiFIWUttI1H6OdtXflu_sIoVfLJhhwTrfQxaBYSXNeMcZpQn98QO-66Nv0nWKSUloUMtUbo701ZXwXgoeFWvlmmTIoStRzfPUcX73ET_D3V2Wsl2Df0bfaCaBr4LFxMPxHpebTi-u19AldF48N</recordid><startdate>202306</startdate><enddate>202306</enddate><creator>Howell, Rebecca J.</creator><creator>Ekbom, Dale</creator><creator>Kasperbauer, Jan</creator><creator>Tabangin, Meredith</creator><creator>Altaye, Mekibib</creator><creator>Wahab, Shaun</creator><creator>Belafsky, Peter</creator><creator>Allen, Jacqui</creator><creator>Amin, Milan</creator><creator>Bayan, Semirra</creator><creator>Cervenka, Brian</creator><creator>deSilva, Brad</creator><creator>Dion, Greg</creator><creator>Friedman, Aaron</creator><creator>Fritz, Mark</creator><creator>Giliberto, John Paul</creator><creator>Guardiani, Elizabeth</creator><creator>Harmon, Jeffrey</creator><creator>Khosla, Sid</creator><creator>Kim, Brandon</creator><creator>Kuhn, Maggie</creator><creator>Kwak, Paul</creator><creator>Ma, Yue</creator><creator>Madden, Lyndsay</creator><creator>Matrka, Laura</creator><creator>Mayerhoff, Ross</creator><creator>Piraka, Cyrus</creator><creator>Rosen, Clark</creator><creator>Wilson, Keith</creator><creator>Wright, Carter</creator><creator>Young, Vyvy</creator><creator>Yuen, Sonia</creator><creator>Postma, Greg</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8770-8463</orcidid><orcidid>https://orcid.org/0000-0002-5503-0325</orcidid><orcidid>https://orcid.org/0000-0003-4300-5146</orcidid><orcidid>https://orcid.org/0000-0003-2345-1157</orcidid><orcidid>https://orcid.org/0000-0003-0288-2839</orcidid></search><sort><creationdate>202306</creationdate><title>Cricopharyngeus Muscle Dysfunction and Hypopharyngeal Diverticula (e.g., Zenker): A Multicenter Study</title><author>Howell, Rebecca J. ; Ekbom, Dale ; Kasperbauer, Jan ; Tabangin, Meredith ; Altaye, Mekibib ; Wahab, Shaun ; Belafsky, Peter ; Allen, Jacqui ; Amin, Milan ; Bayan, Semirra ; Cervenka, Brian ; deSilva, Brad ; Dion, Greg ; Friedman, Aaron ; Fritz, Mark ; Giliberto, John Paul ; Guardiani, Elizabeth ; Harmon, Jeffrey ; Khosla, Sid ; Kim, Brandon ; Kuhn, Maggie ; Kwak, Paul ; Ma, Yue ; Madden, Lyndsay ; Matrka, Laura ; Mayerhoff, Ross ; Piraka, Cyrus ; Rosen, Clark ; Wilson, Keith ; Wright, Carter ; Young, Vyvy ; Yuen, Sonia ; Postma, Greg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3937-c921642dd47c8442255021cdb8dae8a52d98bede8becb50de32a33675688d9ab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cohort Studies</topic><topic>CPMD</topic><topic>cricopharyngeal bar</topic><topic>cricopharyngeal dysfunction</topic><topic>cricopharyngeus muscle dysfunction</topic><topic>Dysphagia</topic><topic>Esophageal Diseases</topic><topic>Esophageal Sphincter, Upper</topic><topic>Esophagus</topic><topic>Female</topic><topic>Humans</topic><topic>hypopharyngeal diverticulum</topic><topic>Killian Jamieson</topic><topic>Laryngoscopy</topic><topic>Muscular Diseases</topic><topic>Otolaryngology</topic><topic>Pharyngeal Diseases</topic><topic>pharyngoesophageal dysphagia</topic><topic>Prospective Studies</topic><topic>Zenker</topic><topic>Zenker Diverticulum - complications</topic><topic>Zenker Diverticulum - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howell, Rebecca J.</creatorcontrib><creatorcontrib>Ekbom, Dale</creatorcontrib><creatorcontrib>Kasperbauer, Jan</creatorcontrib><creatorcontrib>Tabangin, Meredith</creatorcontrib><creatorcontrib>Altaye, Mekibib</creatorcontrib><creatorcontrib>Wahab, Shaun</creatorcontrib><creatorcontrib>Belafsky, Peter</creatorcontrib><creatorcontrib>Allen, Jacqui</creatorcontrib><creatorcontrib>Amin, Milan</creatorcontrib><creatorcontrib>Bayan, Semirra</creatorcontrib><creatorcontrib>Cervenka, Brian</creatorcontrib><creatorcontrib>deSilva, Brad</creatorcontrib><creatorcontrib>Dion, Greg</creatorcontrib><creatorcontrib>Friedman, Aaron</creatorcontrib><creatorcontrib>Fritz, Mark</creatorcontrib><creatorcontrib>Giliberto, John Paul</creatorcontrib><creatorcontrib>Guardiani, Elizabeth</creatorcontrib><creatorcontrib>Harmon, Jeffrey</creatorcontrib><creatorcontrib>Khosla, Sid</creatorcontrib><creatorcontrib>Kim, Brandon</creatorcontrib><creatorcontrib>Kuhn, Maggie</creatorcontrib><creatorcontrib>Kwak, Paul</creatorcontrib><creatorcontrib>Ma, Yue</creatorcontrib><creatorcontrib>Madden, Lyndsay</creatorcontrib><creatorcontrib>Matrka, Laura</creatorcontrib><creatorcontrib>Mayerhoff, Ross</creatorcontrib><creatorcontrib>Piraka, Cyrus</creatorcontrib><creatorcontrib>Rosen, Clark</creatorcontrib><creatorcontrib>Wilson, Keith</creatorcontrib><creatorcontrib>Wright, Carter</creatorcontrib><creatorcontrib>Young, Vyvy</creatorcontrib><creatorcontrib>Yuen, Sonia</creatorcontrib><creatorcontrib>Postma, Greg</creatorcontrib><collection>Wiley Open Access</collection><collection>Wiley-Blackwell Open Access Backfiles (Open Access)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>The Laryngoscope</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Howell, Rebecca J.</au><au>Ekbom, Dale</au><au>Kasperbauer, Jan</au><au>Tabangin, Meredith</au><au>Altaye, Mekibib</au><au>Wahab, Shaun</au><au>Belafsky, Peter</au><au>Allen, Jacqui</au><au>Amin, Milan</au><au>Bayan, Semirra</au><au>Cervenka, Brian</au><au>deSilva, Brad</au><au>Dion, Greg</au><au>Friedman, Aaron</au><au>Fritz, Mark</au><au>Giliberto, John Paul</au><au>Guardiani, Elizabeth</au><au>Harmon, Jeffrey</au><au>Khosla, Sid</au><au>Kim, Brandon</au><au>Kuhn, Maggie</au><au>Kwak, Paul</au><au>Ma, Yue</au><au>Madden, Lyndsay</au><au>Matrka, Laura</au><au>Mayerhoff, Ross</au><au>Piraka, Cyrus</au><au>Rosen, Clark</au><au>Wilson, Keith</au><au>Wright, Carter</au><au>Young, Vyvy</au><au>Yuen, Sonia</au><au>Postma, Greg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cricopharyngeus Muscle Dysfunction and Hypopharyngeal Diverticula (e.g., Zenker): A Multicenter Study</atitle><jtitle>The Laryngoscope</jtitle><addtitle>Laryngoscope</addtitle><date>2023-06</date><risdate>2023</risdate><volume>133</volume><issue>6</issue><spage>1349</spage><epage>1355</epage><pages>1349-1355</pages><issn>0023-852X</issn><eissn>1531-4995</eissn><abstract>Objective
To describe demographics and imaging and compare findings and symptoms at presentation in a large cohort of persons with cricopharyngeus muscle dysfunction (CPMD) with and without hypopharyngeal diverticula.
Methodology
Prospective, multicenter cohort study of all individuals enrolled in the Prospective OUtcomes of Cricopharyngeal Hypertonicity (POUCH) Collaborative. Patient survey, comorbidities, radiography, laryngoscopy findings, and patient‐reported outcome measures (e.g., Eating Assessment Tool [EAT‐10]) data were ed from a REDCap database and summarized using means, medians, percentages, and frequencies. Diagnostic categories were compared using analysis of variance.
Results
A total of 250 persons were included. The mean age (standard deviation [SD]) of the cohort was 69.0 (11.2). Forty‐two percent identified as female. Zenker diverticula (ZD) was diagnosed in 85.2%, 9.2% with CPMD without diverticula, 4.4% with a Killian Jamieson diverticula (KJD), and 1.2% traction‐type diverticula. There were no differences between diagnostic categories in regard to age, gender, and duration of symptoms (p = 0.25, 0.19, 0.45). The mean (SD) EAT‐10 score for each group was 17.1 (10.1) for ZD, 20.2 (9.3) for CPMD, and 10.3 (9.4) for KJD. Patients with isolated CPMD had significantly greater EAT‐10 scores compared to the other diagnostic groups (p = 0.03).
Conclusion
ZD is the most common, followed by CPMD without diverticula, KJD, and traction‐type. Patients with isolated obstructing CPMD may be more symptomatic than persons with ZD or KJD.
Level of Evidence
4 Laryngoscope, 133:1349–1355, 2023
This serves as the seminal work from the prospective, multicenter cohort study of all individuals enrolled in the Prospective OUtcomes of Cricopharyngeal Hypertonicity Surgery (POUCHS) Collaborative. Of the 250 persons enrolled, 85% had a Zenker diverticula (ZD), 9% had evidence of cricopharyngeus muscle dysfunction (CPMD) without diverticula and 4% had a Killian Jamieson diverticula (KJD). Patients with isolated CPMD appear to be more symptomatic than persons with ZD or KJD.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>36102298</pmid><doi>10.1002/lary.30387</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-8770-8463</orcidid><orcidid>https://orcid.org/0000-0002-5503-0325</orcidid><orcidid>https://orcid.org/0000-0003-4300-5146</orcidid><orcidid>https://orcid.org/0000-0003-2345-1157</orcidid><orcidid>https://orcid.org/0000-0003-0288-2839</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0023-852X |
| ispartof | The Laryngoscope, 2023-06, Vol.133 (6), p.1349-1355 |
| issn | 0023-852X 1531-4995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2714392231 |
| source | Wiley-Blackwell Journals; MEDLINE |
| subjects | Cohort Studies CPMD cricopharyngeal bar cricopharyngeal dysfunction cricopharyngeus muscle dysfunction Dysphagia Esophageal Diseases Esophageal Sphincter, Upper Esophagus Female Humans hypopharyngeal diverticulum Killian Jamieson Laryngoscopy Muscular Diseases Otolaryngology Pharyngeal Diseases pharyngoesophageal dysphagia Prospective Studies Zenker Zenker Diverticulum - complications Zenker Diverticulum - surgery |
| title | Cricopharyngeus Muscle Dysfunction and Hypopharyngeal Diverticula (e.g., Zenker): A Multicenter Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T16%3A52%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cricopharyngeus%20Muscle%20Dysfunction%20and%20Hypopharyngeal%20Diverticula%20(e.g.,%20Zenker):%20A%20Multicenter%20Study&rft.jtitle=The%20Laryngoscope&rft.au=Howell,%20Rebecca%20J.&rft.date=2023-06&rft.volume=133&rft.issue=6&rft.spage=1349&rft.epage=1355&rft.pages=1349-1355&rft.issn=0023-852X&rft.eissn=1531-4995&rft_id=info:doi/10.1002/lary.30387&rft_dat=%3Cproquest_cross%3E2811166802%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2811166802&rft_id=info:pmid/36102298&rfr_iscdi=true |