A comprehensive preoperative predictive score for post-hepatectomy liver failure after hepatocellular carcinoma resection based on patient comorbidities, tumor burden, and liver function: the CTF score
Background Post-hepatectomy liver failure (PHLF) is a dreaded complication following liver resection for hepatocellular carcinoma (HCC) with a high mortality rate. We sought to develop a score based on preoperative factors to predict PHLF. Methods Patients who underwent resection for HCC between 200...
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| Veröffentlicht in: | Journal of gastrointestinal surgery 2022-12, Vol.26 (12), p.2486-2495 |
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| creator | Alaimo, Laura Endo, Yutaka Lima, Henrique A. Moazzam, Zorays Shaikh, Chanza Fahim Ruzzenente, Andrea Guglielmi, Alfredo Ratti, Francesca Aldrighetti, Luca Marques, Hugo P. Cauchy, François Lam, Vincent Poultsides, George A. Popescu, Irinel Alexandrescu, Sorin Martel, Guillaume Hugh, Tom Endo, Itaru Pawlik, Timothy M. |
| description | Background
Post-hepatectomy liver failure (PHLF) is a dreaded complication following liver resection for hepatocellular carcinoma (HCC) with a high mortality rate. We sought to develop a score based on preoperative factors to predict PHLF.
Methods
Patients who underwent resection for HCC between 2000 and 2020 were identified from an international multi-institutional database. Factors associated with PHLF were identified and used to develop a preoperative comorbidity-tumor burden-liver function (CTF) predictive score.
Results
Among 1785 patients, 106 (5.9%) experienced PHLF. On multivariate analysis, several factors were associated with PHLF including high Charlson comorbidity index (CCI ≥ 5) (OR 2.80, 95%CI, 1.08–7.26), albumin–bilirubin (ALBI) (OR 1.99, 95%CI, 1.10–3.56), and tumor burden score (TBS) (OR 1.06, 95%CI, 1.02–1.11) (all
p
|
| doi_str_mv | 10.1007/s11605-022-05451-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2714388397</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2714388397</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-5b8d845816fa453694fbf41e63ce04a77ebcb088867a4630efdc52159653b1d03</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhS0EoqXwAiyQJTYsmtaO45_LrrqigFSJTSuxsxxnwnWV2ME_SH1E3grfm1uQWHTlM5pvzox1EHpLyQUlRF4mSgXhDWnbhvCO04Y_Q6dUSdZ0ohXPqyYb2rScfz9Br1K6J4RKQtVLdMJENVCtPEW_r7AN8xJhBz65X4CrDAtEk4_F4OxBJhsi4DFEvISUmx0sJoPNYX7AU-1HPBo3lYqYMdfq0A8WpqlMJmJronU-zAZHSHXMBY97k2DAVVTSgc_7Q0Ls3eBqmc5xLrXEfYkD-HNs_PC4qPiDwUecd4C3t9frba_Ri9FMCd4c3zN0d_3pdvulufn2-ev26qaxTPLc8F4NquOKitF0nIlNN_ZjR0EwC6QzUkJve6KUEtJ0ghEYB8tbyjeCs54OhJ2hD6vvEsPPAinr2aX9R42HUJJuJe2YUmwjK_r-P_Q-lOjrdZViUhApyZ5qV8rGkFKEUS_RzSY-aEr0Pmi9Bq1r0PoQtOZ16N3RuvQzDH9HHpOtAFuBVFv-B8R_u5-w_QNeNrg_</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2737607707</pqid></control><display><type>article</type><title>A comprehensive preoperative predictive score for post-hepatectomy liver failure after hepatocellular carcinoma resection based on patient comorbidities, tumor burden, and liver function: the CTF score</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Alaimo, Laura ; Endo, Yutaka ; Lima, Henrique A. ; Moazzam, Zorays ; Shaikh, Chanza Fahim ; Ruzzenente, Andrea ; Guglielmi, Alfredo ; Ratti, Francesca ; Aldrighetti, Luca ; Marques, Hugo P. ; Cauchy, François ; Lam, Vincent ; Poultsides, George A. ; Popescu, Irinel ; Alexandrescu, Sorin ; Martel, Guillaume ; Hugh, Tom ; Endo, Itaru ; Pawlik, Timothy M.</creator><creatorcontrib>Alaimo, Laura ; Endo, Yutaka ; Lima, Henrique A. ; Moazzam, Zorays ; Shaikh, Chanza Fahim ; Ruzzenente, Andrea ; Guglielmi, Alfredo ; Ratti, Francesca ; Aldrighetti, Luca ; Marques, Hugo P. ; Cauchy, François ; Lam, Vincent ; Poultsides, George A. ; Popescu, Irinel ; Alexandrescu, Sorin ; Martel, Guillaume ; Hugh, Tom ; Endo, Itaru ; Pawlik, Timothy M.</creatorcontrib><description>Background
Post-hepatectomy liver failure (PHLF) is a dreaded complication following liver resection for hepatocellular carcinoma (HCC) with a high mortality rate. We sought to develop a score based on preoperative factors to predict PHLF.
Methods
Patients who underwent resection for HCC between 2000 and 2020 were identified from an international multi-institutional database. Factors associated with PHLF were identified and used to develop a preoperative comorbidity-tumor burden-liver function (CTF) predictive score.
Results
Among 1785 patients, 106 (5.9%) experienced PHLF. On multivariate analysis, several factors were associated with PHLF including high Charlson comorbidity index (CCI ≥ 5) (OR 2.80, 95%CI, 1.08–7.26), albumin–bilirubin (ALBI) (OR 1.99, 95%CI, 1.10–3.56), and tumor burden score (TBS) (OR 1.06, 95%CI, 1.02–1.11) (all
p
< 0.05). Using the beta-coefficients of these variables, a weighted predictive score was developed and made available online (
https://alaimolaura.shinyapps.io/PHLFriskCalculator/
). The CTF score (c-index = 0.67) performed better than Child–Pugh score (CPS) (c-index = 0.53) or Barcelona clinic liver cancer system (BCLC) (c-index = 0.57) to predict PHLF. A high CTF score was also an independent adverse prognostic factor for survival (HR 1.61, 95%CI, 1.12–2.30) and recurrence (HR 1.36, 95%CI, 1.08–1.71) (both
p
= 0.01).
Conclusion
Roughly 1 in 20 patients experienced PHLF following resection of HCC. Patient (i.e., CCI), tumor (i.e., TBS), and liver function (i.e., ALBI) factors were associated with risk of PHLF. These preoperative factors were incorporated into a novel CTF tool that was made available online, which outperformed other previously proposed tools.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-022-05451-5</identifier><identifier>PMID: 36100827</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Bilirubin ; Carcinoma, Hepatocellular - pathology ; Comorbidity ; Gastroenterology ; Hepatectomy ; Hepatectomy - adverse effects ; Humans ; Liver cancer ; Liver Failure - epidemiology ; Liver Failure - etiology ; Liver Neoplasms - pathology ; Medicine ; Medicine & Public Health ; Original Article ; Patients ; Prognosis ; Retrospective Studies ; Serum Albumin ; Surgery ; Tumor Burden</subject><ispartof>Journal of gastrointestinal surgery, 2022-12, Vol.26 (12), p.2486-2495</ispartof><rights>The Society for Surgery of the Alimentary Tract 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Society for Surgery of the Alimentary Tract.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-5b8d845816fa453694fbf41e63ce04a77ebcb088867a4630efdc52159653b1d03</citedby><cites>FETCH-LOGICAL-c375t-5b8d845816fa453694fbf41e63ce04a77ebcb088867a4630efdc52159653b1d03</cites><orcidid>0000-0002-7994-9870</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-022-05451-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-022-05451-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36100827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alaimo, Laura</creatorcontrib><creatorcontrib>Endo, Yutaka</creatorcontrib><creatorcontrib>Lima, Henrique A.</creatorcontrib><creatorcontrib>Moazzam, Zorays</creatorcontrib><creatorcontrib>Shaikh, Chanza Fahim</creatorcontrib><creatorcontrib>Ruzzenente, Andrea</creatorcontrib><creatorcontrib>Guglielmi, Alfredo</creatorcontrib><creatorcontrib>Ratti, Francesca</creatorcontrib><creatorcontrib>Aldrighetti, Luca</creatorcontrib><creatorcontrib>Marques, Hugo P.</creatorcontrib><creatorcontrib>Cauchy, François</creatorcontrib><creatorcontrib>Lam, Vincent</creatorcontrib><creatorcontrib>Poultsides, George A.</creatorcontrib><creatorcontrib>Popescu, Irinel</creatorcontrib><creatorcontrib>Alexandrescu, Sorin</creatorcontrib><creatorcontrib>Martel, Guillaume</creatorcontrib><creatorcontrib>Hugh, Tom</creatorcontrib><creatorcontrib>Endo, Itaru</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><title>A comprehensive preoperative predictive score for post-hepatectomy liver failure after hepatocellular carcinoma resection based on patient comorbidities, tumor burden, and liver function: the CTF score</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Background
Post-hepatectomy liver failure (PHLF) is a dreaded complication following liver resection for hepatocellular carcinoma (HCC) with a high mortality rate. We sought to develop a score based on preoperative factors to predict PHLF.
Methods
Patients who underwent resection for HCC between 2000 and 2020 were identified from an international multi-institutional database. Factors associated with PHLF were identified and used to develop a preoperative comorbidity-tumor burden-liver function (CTF) predictive score.
Results
Among 1785 patients, 106 (5.9%) experienced PHLF. On multivariate analysis, several factors were associated with PHLF including high Charlson comorbidity index (CCI ≥ 5) (OR 2.80, 95%CI, 1.08–7.26), albumin–bilirubin (ALBI) (OR 1.99, 95%CI, 1.10–3.56), and tumor burden score (TBS) (OR 1.06, 95%CI, 1.02–1.11) (all
p
< 0.05). Using the beta-coefficients of these variables, a weighted predictive score was developed and made available online (
https://alaimolaura.shinyapps.io/PHLFriskCalculator/
). The CTF score (c-index = 0.67) performed better than Child–Pugh score (CPS) (c-index = 0.53) or Barcelona clinic liver cancer system (BCLC) (c-index = 0.57) to predict PHLF. A high CTF score was also an independent adverse prognostic factor for survival (HR 1.61, 95%CI, 1.12–2.30) and recurrence (HR 1.36, 95%CI, 1.08–1.71) (both
p
= 0.01).
Conclusion
Roughly 1 in 20 patients experienced PHLF following resection of HCC. Patient (i.e., CCI), tumor (i.e., TBS), and liver function (i.e., ALBI) factors were associated with risk of PHLF. These preoperative factors were incorporated into a novel CTF tool that was made available online, which outperformed other previously proposed tools.</description><subject>Bilirubin</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Comorbidity</subject><subject>Gastroenterology</subject><subject>Hepatectomy</subject><subject>Hepatectomy - adverse effects</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Liver Failure - epidemiology</subject><subject>Liver Failure - etiology</subject><subject>Liver Neoplasms - pathology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Retrospective Studies</subject><subject>Serum Albumin</subject><subject>Surgery</subject><subject>Tumor Burden</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kc1u1TAQhS0EoqXwAiyQJTYsmtaO45_LrrqigFSJTSuxsxxnwnWV2ME_SH1E3grfm1uQWHTlM5pvzox1EHpLyQUlRF4mSgXhDWnbhvCO04Y_Q6dUSdZ0ohXPqyYb2rScfz9Br1K6J4RKQtVLdMJENVCtPEW_r7AN8xJhBz65X4CrDAtEk4_F4OxBJhsi4DFEvISUmx0sJoPNYX7AU-1HPBo3lYqYMdfq0A8WpqlMJmJronU-zAZHSHXMBY97k2DAVVTSgc_7Q0Ls3eBqmc5xLrXEfYkD-HNs_PC4qPiDwUecd4C3t9frba_Ri9FMCd4c3zN0d_3pdvulufn2-ev26qaxTPLc8F4NquOKitF0nIlNN_ZjR0EwC6QzUkJve6KUEtJ0ghEYB8tbyjeCs54OhJ2hD6vvEsPPAinr2aX9R42HUJJuJe2YUmwjK_r-P_Q-lOjrdZViUhApyZ5qV8rGkFKEUS_RzSY-aEr0Pmi9Bq1r0PoQtOZ16N3RuvQzDH9HHpOtAFuBVFv-B8R_u5-w_QNeNrg_</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Alaimo, Laura</creator><creator>Endo, Yutaka</creator><creator>Lima, Henrique A.</creator><creator>Moazzam, Zorays</creator><creator>Shaikh, Chanza Fahim</creator><creator>Ruzzenente, Andrea</creator><creator>Guglielmi, Alfredo</creator><creator>Ratti, Francesca</creator><creator>Aldrighetti, Luca</creator><creator>Marques, Hugo P.</creator><creator>Cauchy, François</creator><creator>Lam, Vincent</creator><creator>Poultsides, George A.</creator><creator>Popescu, Irinel</creator><creator>Alexandrescu, Sorin</creator><creator>Martel, Guillaume</creator><creator>Hugh, Tom</creator><creator>Endo, Itaru</creator><creator>Pawlik, Timothy M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7994-9870</orcidid></search><sort><creationdate>20221201</creationdate><title>A comprehensive preoperative predictive score for post-hepatectomy liver failure after hepatocellular carcinoma resection based on patient comorbidities, tumor burden, and liver function: the CTF score</title><author>Alaimo, Laura ; Endo, Yutaka ; Lima, Henrique A. ; Moazzam, Zorays ; Shaikh, Chanza Fahim ; Ruzzenente, Andrea ; Guglielmi, Alfredo ; Ratti, Francesca ; Aldrighetti, Luca ; Marques, Hugo P. ; Cauchy, François ; Lam, Vincent ; Poultsides, George A. ; Popescu, Irinel ; Alexandrescu, Sorin ; Martel, Guillaume ; Hugh, Tom ; Endo, Itaru ; Pawlik, Timothy M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-5b8d845816fa453694fbf41e63ce04a77ebcb088867a4630efdc52159653b1d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bilirubin</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Comorbidity</topic><topic>Gastroenterology</topic><topic>Hepatectomy</topic><topic>Hepatectomy - adverse effects</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver Failure - epidemiology</topic><topic>Liver Failure - etiology</topic><topic>Liver Neoplasms - pathology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Patients</topic><topic>Prognosis</topic><topic>Retrospective Studies</topic><topic>Serum Albumin</topic><topic>Surgery</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alaimo, Laura</creatorcontrib><creatorcontrib>Endo, Yutaka</creatorcontrib><creatorcontrib>Lima, Henrique A.</creatorcontrib><creatorcontrib>Moazzam, Zorays</creatorcontrib><creatorcontrib>Shaikh, Chanza Fahim</creatorcontrib><creatorcontrib>Ruzzenente, Andrea</creatorcontrib><creatorcontrib>Guglielmi, Alfredo</creatorcontrib><creatorcontrib>Ratti, Francesca</creatorcontrib><creatorcontrib>Aldrighetti, Luca</creatorcontrib><creatorcontrib>Marques, Hugo P.</creatorcontrib><creatorcontrib>Cauchy, François</creatorcontrib><creatorcontrib>Lam, Vincent</creatorcontrib><creatorcontrib>Poultsides, George A.</creatorcontrib><creatorcontrib>Popescu, Irinel</creatorcontrib><creatorcontrib>Alexandrescu, Sorin</creatorcontrib><creatorcontrib>Martel, Guillaume</creatorcontrib><creatorcontrib>Hugh, Tom</creatorcontrib><creatorcontrib>Endo, Itaru</creatorcontrib><creatorcontrib>Pawlik, Timothy M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alaimo, Laura</au><au>Endo, Yutaka</au><au>Lima, Henrique A.</au><au>Moazzam, Zorays</au><au>Shaikh, Chanza Fahim</au><au>Ruzzenente, Andrea</au><au>Guglielmi, Alfredo</au><au>Ratti, Francesca</au><au>Aldrighetti, Luca</au><au>Marques, Hugo P.</au><au>Cauchy, François</au><au>Lam, Vincent</au><au>Poultsides, George A.</au><au>Popescu, Irinel</au><au>Alexandrescu, Sorin</au><au>Martel, Guillaume</au><au>Hugh, Tom</au><au>Endo, Itaru</au><au>Pawlik, Timothy M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A comprehensive preoperative predictive score for post-hepatectomy liver failure after hepatocellular carcinoma resection based on patient comorbidities, tumor burden, and liver function: the CTF score</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>26</volume><issue>12</issue><spage>2486</spage><epage>2495</epage><pages>2486-2495</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Background
Post-hepatectomy liver failure (PHLF) is a dreaded complication following liver resection for hepatocellular carcinoma (HCC) with a high mortality rate. We sought to develop a score based on preoperative factors to predict PHLF.
Methods
Patients who underwent resection for HCC between 2000 and 2020 were identified from an international multi-institutional database. Factors associated with PHLF were identified and used to develop a preoperative comorbidity-tumor burden-liver function (CTF) predictive score.
Results
Among 1785 patients, 106 (5.9%) experienced PHLF. On multivariate analysis, several factors were associated with PHLF including high Charlson comorbidity index (CCI ≥ 5) (OR 2.80, 95%CI, 1.08–7.26), albumin–bilirubin (ALBI) (OR 1.99, 95%CI, 1.10–3.56), and tumor burden score (TBS) (OR 1.06, 95%CI, 1.02–1.11) (all
p
< 0.05). Using the beta-coefficients of these variables, a weighted predictive score was developed and made available online (
https://alaimolaura.shinyapps.io/PHLFriskCalculator/
). The CTF score (c-index = 0.67) performed better than Child–Pugh score (CPS) (c-index = 0.53) or Barcelona clinic liver cancer system (BCLC) (c-index = 0.57) to predict PHLF. A high CTF score was also an independent adverse prognostic factor for survival (HR 1.61, 95%CI, 1.12–2.30) and recurrence (HR 1.36, 95%CI, 1.08–1.71) (both
p
= 0.01).
Conclusion
Roughly 1 in 20 patients experienced PHLF following resection of HCC. Patient (i.e., CCI), tumor (i.e., TBS), and liver function (i.e., ALBI) factors were associated with risk of PHLF. These preoperative factors were incorporated into a novel CTF tool that was made available online, which outperformed other previously proposed tools.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36100827</pmid><doi>10.1007/s11605-022-05451-5</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7994-9870</orcidid></addata></record> |
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| ispartof | Journal of gastrointestinal surgery, 2022-12, Vol.26 (12), p.2486-2495 |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Bilirubin Carcinoma, Hepatocellular - pathology Comorbidity Gastroenterology Hepatectomy Hepatectomy - adverse effects Humans Liver cancer Liver Failure - epidemiology Liver Failure - etiology Liver Neoplasms - pathology Medicine Medicine & Public Health Original Article Patients Prognosis Retrospective Studies Serum Albumin Surgery Tumor Burden |
| title | A comprehensive preoperative predictive score for post-hepatectomy liver failure after hepatocellular carcinoma resection based on patient comorbidities, tumor burden, and liver function: the CTF score |
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