A novel screen-printed potentiometric electrode with carbon nanotubes/polyaniline transducer and molecularly imprinted polymer for the determination of nalbuphine in pharmaceuticals and biological fluids

A novel screen-printed potentiometric electrode with carbon nanotubes/polyaniline transducer and molecularly imprinted polymer for the determination of nalbuphine in pharmaceuticals and biological fluids

A novel screen-printed electrode (SPE) for potentiometric determination of nalbuphine (NAL) is described. Carboxylated multi-walled carbon nano tubes/polyaniline (f-MWCNTs/PANI) nanocomposite is used as an ion-to- electron transducer and is covered by a selective polyvinyl chloride (PVC) membrane in...

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Veröffentlicht in:Analytica chimica acta 2022-09, Vol.1227, p.340239-340239, Article 340239
Hauptverfasser: Hassan, Saad S.M., Kamel, Ayman H., Fathy, Mahmoud Abdelwahab
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Carbon nano tubes /polyaniline nanocomposite
Molecularly imprinted drug polymer
Screen-printed electrode for nalbuphine
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container_title Analytica chimica acta
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creator Hassan, Saad S.M.
Kamel, Ayman H.
Fathy, Mahmoud Abdelwahab
description A novel screen-printed electrode (SPE) for potentiometric determination of nalbuphine (NAL) is described. Carboxylated multi-walled carbon nano tubes/polyaniline (f-MWCNTs/PANI) nanocomposite is used as an ion-to- electron transducer and is covered by a selective polyvinyl chloride (PVC) membrane incorporated with molecularly imprinted drug polymer (MIP) beads as a recognition receptor for potentiometric determination a synthetic narcotic, nalbuphine (NAL). The SPE displays a Nernstian response with a slope of 60.3 ± 1.2 mV/decade (R2 = 0.999) over the concentration range 2.4 × 10−7 – 5.0 × 10−2 mol/L and a detection limit of 1.1 × 10−7 mol/L (0.04 μg/mL) with response time less than 20 s (
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Carboxylated multi-walled carbon nano tubes/polyaniline (f-MWCNTs/PANI) nanocomposite is used as an ion-to- electron transducer and is covered by a selective polyvinyl chloride (PVC) membrane incorporated with molecularly imprinted drug polymer (MIP) beads as a recognition receptor for potentiometric determination a synthetic narcotic, nalbuphine (NAL). The SPE displays a Nernstian response with a slope of 60.3 ± 1.2 mV/decade (R2 = 0.999) over the concentration range 2.4 × 10−7 – 5.0 × 10−2 mol/L and a detection limit of 1.1 × 10−7 mol/L (0.04 μg/mL) with response time less than 20 s (&lt;20 s). The interfacial capacitance of the proposed SPE is measured using chronopotentiometry (CP) and electrochemical impedance spectroscopy (EIS). The use of the f-MWCNTs/PANI nanocomposite layer improved the interfacial capacitance reached 52.5 μF. Besides, it eliminated the formation of the undesired thin water-layer between the sensing membrane and the conducting substrate. This prevents membrane delamination and increases potential stability. The obtained high selectivity, sensitivity and potential stability offered a great applicability of the proposed SPE for the determination of nalbuphine in hospitals for rapid diagnosis of overdose patients and for quality control/quality assurance in pharmaceutical industry. 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Carboxylated multi-walled carbon nano tubes/polyaniline (f-MWCNTs/PANI) nanocomposite is used as an ion-to- electron transducer and is covered by a selective polyvinyl chloride (PVC) membrane incorporated with molecularly imprinted drug polymer (MIP) beads as a recognition receptor for potentiometric determination a synthetic narcotic, nalbuphine (NAL). The SPE displays a Nernstian response with a slope of 60.3 ± 1.2 mV/decade (R2 = 0.999) over the concentration range 2.4 × 10−7 – 5.0 × 10−2 mol/L and a detection limit of 1.1 × 10−7 mol/L (0.04 μg/mL) with response time less than 20 s (&lt;20 s). The interfacial capacitance of the proposed SPE is measured using chronopotentiometry (CP) and electrochemical impedance spectroscopy (EIS). The use of the f-MWCNTs/PANI nanocomposite layer improved the interfacial capacitance reached 52.5 μF. Besides, it eliminated the formation of the undesired thin water-layer between the sensing membrane and the conducting substrate. This prevents membrane delamination and increases potential stability. The obtained high selectivity, sensitivity and potential stability offered a great applicability of the proposed SPE for the determination of nalbuphine in hospitals for rapid diagnosis of overdose patients and for quality control/quality assurance in pharmaceutical industry. 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Carboxylated multi-walled carbon nano tubes/polyaniline (f-MWCNTs/PANI) nanocomposite is used as an ion-to- electron transducer and is covered by a selective polyvinyl chloride (PVC) membrane incorporated with molecularly imprinted drug polymer (MIP) beads as a recognition receptor for potentiometric determination a synthetic narcotic, nalbuphine (NAL). The SPE displays a Nernstian response with a slope of 60.3 ± 1.2 mV/decade (R2 = 0.999) over the concentration range 2.4 × 10−7 – 5.0 × 10−2 mol/L and a detection limit of 1.1 × 10−7 mol/L (0.04 μg/mL) with response time less than 20 s (&lt;20 s). The interfacial capacitance of the proposed SPE is measured using chronopotentiometry (CP) and electrochemical impedance spectroscopy (EIS). The use of the f-MWCNTs/PANI nanocomposite layer improved the interfacial capacitance reached 52.5 μF. Besides, it eliminated the formation of the undesired thin water-layer between the sensing membrane and the conducting substrate. This prevents membrane delamination and increases potential stability. The obtained high selectivity, sensitivity and potential stability offered a great applicability of the proposed SPE for the determination of nalbuphine in hospitals for rapid diagnosis of overdose patients and for quality control/quality assurance in pharmaceutical industry. [Display omitted] •Cost-effective screen-printed potentiometric sensors for nalbuphine determination.•Molecularly imprinted polymer was used as a recognition receptor.•Detailed characterization of the sensors and validation were reported.•Application to different biological fluids.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.aca.2022.340239</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-6873-2991</orcidid><orcidid>https://orcid.org/0000-0001-7502-6668</orcidid></addata></record>
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subjects Carbon nano tubes /polyaniline nanocomposite
Molecularly imprinted drug polymer
Screen-printed electrode for nalbuphine
title A novel screen-printed potentiometric electrode with carbon nanotubes/polyaniline transducer and molecularly imprinted polymer for the determination of nalbuphine in pharmaceuticals and biological fluids
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