Crystal engineering of ferrocene-based charge-transfer complexes for NIR-II photothermal therapy and ferroptosis
Organic charge-transfer complexes (CTCs) can function as versatile second near-infrared (NIR-II) theranostic platforms to tackle complicated solid tumors, while the structure-property relationship is still an unanswered problem. To uncover the effect of molecular stacking modes on photophysical and...
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| Veröffentlicht in: | Chemical science (Cambridge) 2022-08, Vol.13 (32), p.941-949 |
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| creator | Ge, Wei Liu, Chao Xu, Yatao Zhang, Jiayao Si, Weili Wang, Wenjun Ou, Changjin Dong, Xiaochen |
| description | Organic charge-transfer complexes (CTCs) can function as versatile second near-infrared (NIR-II) theranostic platforms to tackle complicated solid tumors, while the structure-property relationship is still an unanswered problem. To uncover the effect of molecular stacking modes on photophysical and biochemical properties, herein, five ferrocene derivatives were synthesized as electron donors and co-assembled with electron-deficient F4TCNQ to form the corresponding CTCs. The crystalline and photophysical results showed that only herringbone-aligned CTCs (named anion-radical salts, ARS NPs) possess good NIR-II absorption ability and a photothermal effect for short π-π distances ( |
| doi_str_mv | 10.1039/d2sc03273b |
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In vitro
experiments, FcNEt-F4 NPs, and typical ARS NPs, show outstanding antitumor efficiency for the synergistic effect of NIR-II photothermal therapy and ferroptosis, which provides a new paradigm to develop versatile CTCs for anti-tumor application.
Based on crystal engineering of charge transfer complexes (CTCs), ferrocene-based CTCs, with Fenton-catalyzing, biothiol-responsive and NIR-II photothermal abilities, were controllably developed and the structure-property relationship was revealed.</description><identifier>ISSN: 2041-6520</identifier><identifier>EISSN: 2041-6539</identifier><identifier>DOI: 10.1039/d2sc03273b</identifier><identifier>PMID: 36093016</identifier><language>eng</language><publisher>Cambridge: Royal Society of Chemistry</publisher><subject>Anions ; Charge transfer ; Chemistry ; Depletion ; Homeostasis ; Near infrared radiation ; Pi-electrons ; Synergistic effect</subject><ispartof>Chemical science (Cambridge), 2022-08, Vol.13 (32), p.941-949</ispartof><rights>Copyright Royal Society of Chemistry 2022</rights><rights>This journal is © The Royal Society of Chemistry 2022 The Royal Society of Chemistry</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c335t-3b50d2530135b416d1baa4823b2a472ea963abdd9fae4a852f6c1f92336fdb3f3</citedby><cites>FETCH-LOGICAL-c335t-3b50d2530135b416d1baa4823b2a472ea963abdd9fae4a852f6c1f92336fdb3f3</cites><orcidid>0000-0002-8688-5908 ; 0000-0003-4269-9350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384818/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9384818/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Ge, Wei</creatorcontrib><creatorcontrib>Liu, Chao</creatorcontrib><creatorcontrib>Xu, Yatao</creatorcontrib><creatorcontrib>Zhang, Jiayao</creatorcontrib><creatorcontrib>Si, Weili</creatorcontrib><creatorcontrib>Wang, Wenjun</creatorcontrib><creatorcontrib>Ou, Changjin</creatorcontrib><creatorcontrib>Dong, Xiaochen</creatorcontrib><title>Crystal engineering of ferrocene-based charge-transfer complexes for NIR-II photothermal therapy and ferroptosis</title><title>Chemical science (Cambridge)</title><description>Organic charge-transfer complexes (CTCs) can function as versatile second near-infrared (NIR-II) theranostic platforms to tackle complicated solid tumors, while the structure-property relationship is still an unanswered problem. To uncover the effect of molecular stacking modes on photophysical and biochemical properties, herein, five ferrocene derivatives were synthesized as electron donors and co-assembled with electron-deficient F4TCNQ to form the corresponding CTCs. The crystalline and photophysical results showed that only herringbone-aligned CTCs (named anion-radical salts, ARS NPs) possess good NIR-II absorption ability and a photothermal effect for short π-π distances (<3.24 Å) and strong π-electron delocalization in the 1D F4TCNQ anion chain. More importantly, the ARS NPs simultaneously possess ·OH generation and thiol (Cys, GSH) depletion abilities to perturb cellular redox homeostasis for ROS/LPO accumulation and enhanced ferroptosis.
In vitro
experiments, FcNEt-F4 NPs, and typical ARS NPs, show outstanding antitumor efficiency for the synergistic effect of NIR-II photothermal therapy and ferroptosis, which provides a new paradigm to develop versatile CTCs for anti-tumor application.
Based on crystal engineering of charge transfer complexes (CTCs), ferrocene-based CTCs, with Fenton-catalyzing, biothiol-responsive and NIR-II photothermal abilities, were controllably developed and the structure-property relationship was revealed.</description><subject>Anions</subject><subject>Charge transfer</subject><subject>Chemistry</subject><subject>Depletion</subject><subject>Homeostasis</subject><subject>Near infrared radiation</subject><subject>Pi-electrons</subject><subject>Synergistic effect</subject><issn>2041-6520</issn><issn>2041-6539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpdkUlrHDEQRkVIiI3tS-4GgS8h0LGk6vViSMZZBowNWc5CS2mmTbfUkXqC599bkzFjHF1KUI_HV3yEvOPsI2fQXVqRDAPRgH5FjgUreVFX0L0-_AU7Imcp3bP8AHglmrfkCGrWAeP1MZkWcZtmNVD0q94jxt6vaHDUYYzBoMdCq4SWmrWKKyzmqHzKO2rCOA34gIm6EOnt8kexXNJpHeYwrzGOWbibatpS5e3eNs0h9emUvHFqSHj2NE_I769ffi2-Fzd335aLTzeFAajmAnTFrKhySKh0yWvLtVJlK0ALVTYCVVeD0tZ2TmGp2kq42nDXCYDaWQ0OTsjV3jtt9Ig2n5KzD3KK_ajiVgbVy5cb36_lKvyVHbRly9sseP8kiOHPBtMsxz4ZHAblMWySFA0HYC3jIqMX_6H3YRN9Pi9TDKqm7Nod9WFPmRhSiugOYTiTuy7ltfi5-Nfl5wyf7-GYzIF77hoeASYVm68</recordid><startdate>20220817</startdate><enddate>20220817</enddate><creator>Ge, Wei</creator><creator>Liu, Chao</creator><creator>Xu, Yatao</creator><creator>Zhang, Jiayao</creator><creator>Si, Weili</creator><creator>Wang, Wenjun</creator><creator>Ou, Changjin</creator><creator>Dong, Xiaochen</creator><general>Royal Society of Chemistry</general><general>The Royal Society of Chemistry</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8688-5908</orcidid><orcidid>https://orcid.org/0000-0003-4269-9350</orcidid></search><sort><creationdate>20220817</creationdate><title>Crystal engineering of ferrocene-based charge-transfer complexes for NIR-II photothermal therapy and ferroptosis</title><author>Ge, Wei ; Liu, Chao ; Xu, Yatao ; Zhang, Jiayao ; Si, Weili ; Wang, Wenjun ; Ou, Changjin ; Dong, Xiaochen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-3b50d2530135b416d1baa4823b2a472ea963abdd9fae4a852f6c1f92336fdb3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Anions</topic><topic>Charge transfer</topic><topic>Chemistry</topic><topic>Depletion</topic><topic>Homeostasis</topic><topic>Near infrared radiation</topic><topic>Pi-electrons</topic><topic>Synergistic effect</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ge, Wei</creatorcontrib><creatorcontrib>Liu, Chao</creatorcontrib><creatorcontrib>Xu, Yatao</creatorcontrib><creatorcontrib>Zhang, Jiayao</creatorcontrib><creatorcontrib>Si, Weili</creatorcontrib><creatorcontrib>Wang, Wenjun</creatorcontrib><creatorcontrib>Ou, Changjin</creatorcontrib><creatorcontrib>Dong, Xiaochen</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Chemical science (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ge, Wei</au><au>Liu, Chao</au><au>Xu, Yatao</au><au>Zhang, Jiayao</au><au>Si, Weili</au><au>Wang, Wenjun</au><au>Ou, Changjin</au><au>Dong, Xiaochen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Crystal engineering of ferrocene-based charge-transfer complexes for NIR-II photothermal therapy and ferroptosis</atitle><jtitle>Chemical science (Cambridge)</jtitle><date>2022-08-17</date><risdate>2022</risdate><volume>13</volume><issue>32</issue><spage>941</spage><epage>949</epage><pages>941-949</pages><issn>2041-6520</issn><eissn>2041-6539</eissn><abstract>Organic charge-transfer complexes (CTCs) can function as versatile second near-infrared (NIR-II) theranostic platforms to tackle complicated solid tumors, while the structure-property relationship is still an unanswered problem. To uncover the effect of molecular stacking modes on photophysical and biochemical properties, herein, five ferrocene derivatives were synthesized as electron donors and co-assembled with electron-deficient F4TCNQ to form the corresponding CTCs. The crystalline and photophysical results showed that only herringbone-aligned CTCs (named anion-radical salts, ARS NPs) possess good NIR-II absorption ability and a photothermal effect for short π-π distances (<3.24 Å) and strong π-electron delocalization in the 1D F4TCNQ anion chain. More importantly, the ARS NPs simultaneously possess ·OH generation and thiol (Cys, GSH) depletion abilities to perturb cellular redox homeostasis for ROS/LPO accumulation and enhanced ferroptosis.
In vitro
experiments, FcNEt-F4 NPs, and typical ARS NPs, show outstanding antitumor efficiency for the synergistic effect of NIR-II photothermal therapy and ferroptosis, which provides a new paradigm to develop versatile CTCs for anti-tumor application.
Based on crystal engineering of charge transfer complexes (CTCs), ferrocene-based CTCs, with Fenton-catalyzing, biothiol-responsive and NIR-II photothermal abilities, were controllably developed and the structure-property relationship was revealed.</abstract><cop>Cambridge</cop><pub>Royal Society of Chemistry</pub><pmid>36093016</pmid><doi>10.1039/d2sc03273b</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-8688-5908</orcidid><orcidid>https://orcid.org/0000-0003-4269-9350</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anions Charge transfer Chemistry Depletion Homeostasis Near infrared radiation Pi-electrons Synergistic effect |
| title | Crystal engineering of ferrocene-based charge-transfer complexes for NIR-II photothermal therapy and ferroptosis |
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