Many faces of SF3B1-mutated myeloid neoplasms: concurrent mutational profiles contribute to the diverse clinical and morphologic features

Splicing factor SF3B1 mutation occurs in 20-30% of myelodysplastic syndrome (MDS) and myelodysplasia/myeloproliferative neoplasm (MDS/MPN), particularly those with ring sideroblasts (RS), and rarely in acute myeloid leukemia (AML). In this study, we performed a comprehensive evaluation of 77 SF3B1-m...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Human pathology 2022-11, Vol.129, p.81-89
Hauptverfasser:	Aqil, Barina, Sukhanova, Madina, Behdad, Amir, Jennings, Lawrence, Lu, Xinyan, Chen, Qing, Chen, Yi-Hua, Gao, Juehua
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood DNA methylation Epigenetics Genes Humans Leukemia Leukemia, Myeloid, Acute - genetics Mutation Myelodysplastic syndromes Myelodysplastic Syndromes - genetics Myelodysplastic-Myeloproliferative Diseases - genetics Myeloproliferative Disorders - genetics Phosphoproteins - genetics RNA Splicing Factors - genetics Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!