Comparison of incorporation of wild type and mutated actins into sarcomeres in skeletal muscle cells: A fluorescence recovery after photobleaching study

The α‐actin mutation G15R in the nucleotide‐binding pocket of skeletal muscle, causes severe actin myopathy in human skeletal muscles. Expressed in cultured embryonic quail skeletal myotubes, YFP‐G15R‐α‐actin incorporates in sarcomeres in a pattern indistinguishable from wildtype YFP‐α‐actin. Howeve...

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Veröffentlicht in:	Cytoskeleton (Hoboken, N.J.) N.J.), 2022-09, Vol.79 (9-11), p.105-115
Hauptverfasser:	Wang, Jushuo, Fan, Yingli, Mittal, Balraj, Sanger, Jean M., Sanger, Joseph W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin actin dynamics actin mutations Actins - genetics Actins - metabolism cytochalasin‐D Embryos Filaments Fluorescence recovery after photobleaching FRAP Humans mature myofibrils Monomers Muscle, Skeletal - metabolism Musculoskeletal system Mutation Myofibrils Myofibrils - metabolism Myopathy Myotubes Nucleotides - metabolism Photobleaching Sarcomeres Sarcomeres - metabolism Skeletal muscle
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