Semaglutide ameliorates lipopolysaccharide-induced acute lung injury through inhibiting HDAC5-mediated activation of NF-κB signaling pathway

Background As a life-threatening respiratory syndrome, acute lung injury (ALI) is characterized by uncontrollable inflammatory activities. Semaglutide (SEM) has been identified as an effective anti-inflammatory drug in a variety of diseases. This study intended to explore the functional effect and p...

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Veröffentlicht in:	Human & experimental toxicology 2022-09, Vol.41, p.9603271221125931-9603271221125931
Hauptverfasser:	Jiang, Zeyu, Tan, Jinyi, Yuan, Yan, Shen, Jiang, Chen, Yan
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Apoptosis Bcl-2 protein Caspase-3 Cholecystokinin Endothelial cells Flow cytometry In vivo methods and tests Inflammation Injury prevention Interleukin 6 Lipopolysaccharides Lungs Mathematical models NF-κB protein Pulmonary arteries Pulmonary artery Signal transduction Tumor necrosis factor-α Western blotting
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