Multimarker Responses of Zebrafish to the Effect of Ibuprofen and Gemfibrozil in Environmentally Relevant Concentrations
Pharmaceutical pollution of water bodies is among the top-notch environmental health risks all over the world. The aim of the present study was to investigate the effects of two common pharmaceuticals namely ibuprofen and gemfibrozil on zebrafish at environmentally relevant concentrations. In zebraf...
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| Veröffentlicht in: | Bulletin of environmental contamination and toxicology 2022-12, Vol.109 (6), p.1010-1017 |
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| creator | Falfushynska, Halina Poznanskyi, Dmytro Kasianchuk, Nadiia Horyn, Oksana Bodnar, Oksana |
| description | Pharmaceutical pollution of water bodies is among the top-notch environmental health risks all over the world. The aim of the present study was to investigate the effects of two common pharmaceuticals namely ibuprofen and gemfibrozil on zebrafish at environmentally relevant concentrations. In zebrafish liver, gemfibrozil caused a decrease in glutathione and glutathione transferase and an increase in catalase but had no effect on lipid peroxidation and protein carbonylation. Ibuprofen altered the antioxidant defense system, promoted protein carbonylation in zebrafish liver, and increased vitellogenin-like protein in the blood. Ibuprofen and particularly gemfibrozil induced lysosomes biogenesis. Lactate dehydrogenase in the blood was also found to be higher in the studied groups. Studied pharmaceuticals did not affect complex II of the electron respiratory chain. Ibuprofen affects zebrafish health status more profoundly than gemfibrozil. Our results showed that pharmaceuticals even in low, environmentally realistic concentrations, induced profound changes in the stress-responsive systems of zebrafish. |
| doi_str_mv | 10.1007/s00128-022-03607-2 |
| format | Article |
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The aim of the present study was to investigate the effects of two common pharmaceuticals namely ibuprofen and gemfibrozil on zebrafish at environmentally relevant concentrations. In zebrafish liver, gemfibrozil caused a decrease in glutathione and glutathione transferase and an increase in catalase but had no effect on lipid peroxidation and protein carbonylation. Ibuprofen altered the antioxidant defense system, promoted protein carbonylation in zebrafish liver, and increased vitellogenin-like protein in the blood. Ibuprofen and particularly gemfibrozil induced lysosomes biogenesis. Lactate dehydrogenase in the blood was also found to be higher in the studied groups. Studied pharmaceuticals did not affect complex II of the electron respiratory chain. Ibuprofen affects zebrafish health status more profoundly than gemfibrozil. Our results showed that pharmaceuticals even in low, environmentally realistic concentrations, induced profound changes in the stress-responsive systems of zebrafish.</description><identifier>ISSN: 0007-4861</identifier><identifier>EISSN: 1432-0800</identifier><identifier>DOI: 10.1007/s00128-022-03607-2</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Aquatic Pollution ; Biomarkers ; Blood ; Carbonyls ; Catalase ; Danio rerio ; Earth and Environmental Science ; Ecotoxicology ; Electron transport ; Environment ; Environmental Chemistry ; Environmental Health ; Ethanol ; Experiments ; Gemfibrozil ; Glutathione ; Glutathione transferase ; Health risks ; Ibuprofen ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Lipid peroxidation ; Lipids ; Liver ; Lysosomes ; Nonsteroidal anti-inflammatory drugs ; Oxidative stress ; Pedagogy ; Peroxidation ; Pharmaceutical industry wastes ; Pharmaceuticals ; Pollution ; Proteins ; Soil Science & Conservation ; Toxicology ; Vitellogenin ; Waste Water Technology ; Water Management ; Water pollution ; Water Pollution Control ; Zebrafish</subject><ispartof>Bulletin of environmental contamination and toxicology, 2022-12, Vol.109 (6), p.1010-1017</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. 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The aim of the present study was to investigate the effects of two common pharmaceuticals namely ibuprofen and gemfibrozil on zebrafish at environmentally relevant concentrations. In zebrafish liver, gemfibrozil caused a decrease in glutathione and glutathione transferase and an increase in catalase but had no effect on lipid peroxidation and protein carbonylation. Ibuprofen altered the antioxidant defense system, promoted protein carbonylation in zebrafish liver, and increased vitellogenin-like protein in the blood. Ibuprofen and particularly gemfibrozil induced lysosomes biogenesis. Lactate dehydrogenase in the blood was also found to be higher in the studied groups. Studied pharmaceuticals did not affect complex II of the electron respiratory chain. Ibuprofen affects zebrafish health status more profoundly than gemfibrozil. Our results showed that pharmaceuticals even in low, environmentally realistic concentrations, induced profound changes in the stress-responsive systems of zebrafish.</description><subject>Animals</subject><subject>Aquatic Pollution</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Carbonyls</subject><subject>Catalase</subject><subject>Danio rerio</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Electron transport</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Ethanol</subject><subject>Experiments</subject><subject>Gemfibrozil</subject><subject>Glutathione</subject><subject>Glutathione transferase</subject><subject>Health risks</subject><subject>Ibuprofen</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Lipid 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| subjects | Animals Aquatic Pollution Biomarkers Blood Carbonyls Catalase Danio rerio Earth and Environmental Science Ecotoxicology Electron transport Environment Environmental Chemistry Environmental Health Ethanol Experiments Gemfibrozil Glutathione Glutathione transferase Health risks Ibuprofen L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lipid peroxidation Lipids Liver Lysosomes Nonsteroidal anti-inflammatory drugs Oxidative stress Pedagogy Peroxidation Pharmaceutical industry wastes Pharmaceuticals Pollution Proteins Soil Science & Conservation Toxicology Vitellogenin Waste Water Technology Water Management Water pollution Water Pollution Control Zebrafish |
| title | Multimarker Responses of Zebrafish to the Effect of Ibuprofen and Gemfibrozil in Environmentally Relevant Concentrations |
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