Acquired Genomic Alterations on First-Line Chemotherapy With Cetuximab in Advanced Colorectal Cancer: Circulating Tumor DNA Analysis of the CALGB/SWOG-80405 Trial (Alliance)

JCO Acquired genomic alterations (Acq-GAs), specifically , , and -ectodomain mutations and and amplifications, are recognized as major mechanisms of resistance to later-line anti-EGFR-antibody therapy in metastatic colorectal cancer (mCRC). However, data regarding emergence of these Acq-GAs under th...

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Veröffentlicht in:	Journal of clinical oncology 2023-01, Vol.41 (3), p.472-478
Hauptverfasser:	Raghav, Kanwal, Ou, Fang-Shu, Venook, Alan P, Innocenti, Federico, Sun, Ryan, Lenz, Heinz-Josef, Kopetz, Scott
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols Cetuximab - therapeutic use Circulating Tumor DNA - genetics Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology DNA, Neoplasm Genomics Humans Mutation Proto-Oncogene Proteins B-raf - genetics
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