Human Pro370Leu Mutant Myocilin Induces the Phenotype of Open-Angle Glaucoma in Transgenic Mice

To investigate the characteristics of mutation myocilin proteins and glaucoma pathological phenotype in transgenic mice with full-length human Pro370Leu mutant myocilin gene (Tg- MYOC P370L ). Tg- MYOC P370L mice were established using the CRISPR/Cas9 system. Long-term intraocular pressure (IOP) was...

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Veröffentlicht in:	Cellular and molecular neurobiology 2023-07, Vol.43 (5), p.2021-2033
Hauptverfasser:	Cheng, Ying, Wu, Shen, Yan, Xuejing, Liu, Qian, Lin, Danting, Zhang, Jingxue, Wang, Ningli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Anterior chamber Apoptosis Biomedical and Life Sciences Biomedicine Caspase-3 Caspase-9 Cell activation Cell Biology CRISPR Eye Gadolinium Genotype & phenotype Glaucoma Glial cells Glial fibrillary acidic protein Immunofluorescence Magnetic resonance imaging Morphology Mutants Mutation Neurobiology Neurosciences Optic nerve Original Research Phenotypes Proteins Retina Retinal ganglion cells Transgenic animals Transgenic mice Visual perception
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