Is histopathological synovitis score a predictor of postoperative requirement for additional or alternative drug treatment in the patients with rheumatoid arthritis?

Is histopathological synovitis score a predictor of postoperative requirement for additional or alternative drug treatment in the patients with rheumatoid arthritis?

ABSTRACT Objectives Histopathological synovitis scoring is useful for assessing activity in patients with rheumatoid arthritis (RA) at sampling, but it is unclear whether it can be a predictor of future drug treatment. The purpose of this study was to examine whether histopathological synovitis scor...

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Veröffentlicht in:Modern rheumatology 2023-08, Vol.33 (5), p.906-910
Hauptverfasser: Koyama, Kensuke, Wako, Masanori, Ohba, Tetsuro, Nakagomi, Daiki, Koizumi, Ryousuke, Haro, Hirotaka
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container_end_page 910
container_issue 5
container_start_page 906
container_title Modern rheumatology
container_volume 33
creator Koyama, Kensuke
Wako, Masanori
Ohba, Tetsuro
Nakagomi, Daiki
Koizumi, Ryousuke
Haro, Hirotaka
description ABSTRACT Objectives Histopathological synovitis scoring is useful for assessing activity in patients with rheumatoid arthritis (RA) at sampling, but it is unclear whether it can be a predictor of future drug treatment. The purpose of this study was to examine whether histopathological synovitis score is a predictor of postoperative requirement for additional or alternative drug treatment after total knee arthroplasty (TKA). Methods Thirty patients with RA in whom synovial samples were obtained during TKA were included. Patients were divided into the drug treatment enhanced group (EG), which included patients who needed additional or alternative drug treatment within 1 year after TKA, and the drug treatment maintenance group (MG). The Rooney synovitis score (RSS) was compared between groups. Logistic regression analysis was performed to clarify prognostic factors for postoperative drug treatment change. Results The total RSS was significantly higher in the EG than in the MG (29.3 vs 15.1; P 
doi_str_mv 10.1093/mr/roac108
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The purpose of this study was to examine whether histopathological synovitis score is a predictor of postoperative requirement for additional or alternative drug treatment after total knee arthroplasty (TKA). Methods Thirty patients with RA in whom synovial samples were obtained during TKA were included. Patients were divided into the drug treatment enhanced group (EG), which included patients who needed additional or alternative drug treatment within 1 year after TKA, and the drug treatment maintenance group (MG). The Rooney synovitis score (RSS) was compared between groups. Logistic regression analysis was performed to clarify prognostic factors for postoperative drug treatment change. Results The total RSS was significantly higher in the EG than in the MG (29.3 vs 15.1; P &lt; .001). Multivariate analysis showed that total RSS and swollen joint counts were independent variable associated with postoperative requirement for additional or alternative drug treatment (P &lt; .05). Conclusions Histopathological synovitis scoring may predict requirement for additional or alternative drug treatment in patients with RA after TKA.</description><identifier>ISSN: 1439-7595</identifier><identifier>EISSN: 1439-7609</identifier><identifier>DOI: 10.1093/mr/roac108</identifier><language>eng</language><publisher>UK: Oxford University Press</publisher><ispartof>Modern rheumatology, 2023-08, Vol.33 (5), p.906-910</ispartof><rights>Japan College of Rheumatology 2022. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2022</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c253t-53c88bd1e69dace438264bc4446178c1a346df037b895e26053a67d2e8c680b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids></links><search><creatorcontrib>Koyama, Kensuke</creatorcontrib><creatorcontrib>Wako, Masanori</creatorcontrib><creatorcontrib>Ohba, Tetsuro</creatorcontrib><creatorcontrib>Nakagomi, Daiki</creatorcontrib><creatorcontrib>Koizumi, Ryousuke</creatorcontrib><creatorcontrib>Haro, Hirotaka</creatorcontrib><title>Is histopathological synovitis score a predictor of postoperative requirement for additional or alternative drug treatment in the patients with rheumatoid arthritis?</title><title>Modern rheumatology</title><description>ABSTRACT Objectives Histopathological synovitis scoring is useful for assessing activity in patients with rheumatoid arthritis (RA) at sampling, but it is unclear whether it can be a predictor of future drug treatment. The purpose of this study was to examine whether histopathological synovitis score is a predictor of postoperative requirement for additional or alternative drug treatment after total knee arthroplasty (TKA). Methods Thirty patients with RA in whom synovial samples were obtained during TKA were included. Patients were divided into the drug treatment enhanced group (EG), which included patients who needed additional or alternative drug treatment within 1 year after TKA, and the drug treatment maintenance group (MG). The Rooney synovitis score (RSS) was compared between groups. Logistic regression analysis was performed to clarify prognostic factors for postoperative drug treatment change. Results The total RSS was significantly higher in the EG than in the MG (29.3 vs 15.1; P &lt; .001). Multivariate analysis showed that total RSS and swollen joint counts were independent variable associated with postoperative requirement for additional or alternative drug treatment (P &lt; .05). 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The purpose of this study was to examine whether histopathological synovitis score is a predictor of postoperative requirement for additional or alternative drug treatment after total knee arthroplasty (TKA). Methods Thirty patients with RA in whom synovial samples were obtained during TKA were included. Patients were divided into the drug treatment enhanced group (EG), which included patients who needed additional or alternative drug treatment within 1 year after TKA, and the drug treatment maintenance group (MG). The Rooney synovitis score (RSS) was compared between groups. Logistic regression analysis was performed to clarify prognostic factors for postoperative drug treatment change. Results The total RSS was significantly higher in the EG than in the MG (29.3 vs 15.1; P &lt; .001). Multivariate analysis showed that total RSS and swollen joint counts were independent variable associated with postoperative requirement for additional or alternative drug treatment (P &lt; .05). Conclusions Histopathological synovitis scoring may predict requirement for additional or alternative drug treatment in patients with RA after TKA.</abstract><cop>UK</cop><pub>Oxford University Press</pub><doi>10.1093/mr/roac108</doi><tpages>5</tpages></addata></record>
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title Is histopathological synovitis score a predictor of postoperative requirement for additional or alternative drug treatment in the patients with rheumatoid arthritis?
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