Role of thyroid hormones-induced oxidative stress on cardiovascular physiology
Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular homeostasis and are involved in the modulation of cardiac contractility, heart rate, diastolic function, systemic vascular resistance, and vasodilation. THs have actions on cardiovascular physiology through the activa...
Gespeichert in:
Veröffentlicht in: | Biochimica et biophysica acta. General subjects 2022-12, Vol.1866 (12), p.130239-130239, Article 130239 |
---|---|
1. Verfasser: | |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 130239 |
---|---|
container_issue | 12 |
container_start_page | 130239 |
container_title | Biochimica et biophysica acta. General subjects |
container_volume | 1866 |
creator | Barreiro Arcos, María Laura |
description | Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular homeostasis and are involved in the modulation of cardiac contractility, heart rate, diastolic function, systemic vascular resistance, and vasodilation. THs have actions on cardiovascular physiology through the activation or repression of target genes or the activation of intracellular signals through non-genomic mechanisms. Hyperthyroidism alters certain intracellular pathways involved in the preservation of the structure and functionality of the heart, causing relevant cardiovascular disorders. Reactive oxygen species (ROS) play an important role in the cardiovascular system, but the exacerbated increase in ROS caused by chronic hyperthyroidism together with regulation on the antioxidant system have been associated with the development of cardiovascular dysfunction. In this review, we analyze the role of THs-induced oxidative stress in the cellular and molecular changes that lead to cardiac dysfunction, as well as the effectiveness of antioxidant treatments in attenuating cardiac abnormalities developed during hyperthyroidism.
•Thyroid hormones exert effects on the heart through genomic and non-genomic actions.•Thyroid hormones induce oxidative stress in heart tissue.•ROS modulate signaling pathways that cause changes in cardiovascular physiology.•Antioxidants could attenuate the cardiac abnormalities induced by hyperthyroidism. |
doi_str_mv | 10.1016/j.bbagen.2022.130239 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2710973561</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S030441652200157X</els_id><sourcerecordid>2710973561</sourcerecordid><originalsourceid>FETCH-LOGICAL-c372t-6e5cc65a466ea1bf981b765218247f0e78f179edb688042ba3935faf9458c90c3</originalsourceid><addsrcrecordid>eNqNkEtLxDAUhYMoOI7-AxddumlN0ua1EWTwBYOC6Dqk6c1Mhk4zJu3g_Hs71LV4N2fznQP3Q-ia4IJgwm83RV2bFXQFxZQWpMS0VCdoRqSgucSYn6IZLnGVV4Szc3SR0gaPxxSbodf30EIWXNavDzH4JluHuA0dpNx3zWChycK3b0zv95ClPkJKWegya2Ljw94kO7QmZrv1IfnQhtXhEp050ya4-s05-nx8-Fg858u3p5fF_TK3paB9zoFZy5mpOAdDaqckqQVnlEhaCYdBSEeEgqbmUuKK1qZUJXPGqYpJq7At5-hm2t3F8DVA6vXWJwttazoIQ9JU0JIQQZX4B0rwiDFORrSaUBtDShGc3kW_NfGgCdZH03qjJ9P6aFpPpsfa3VSD8eO9h6iT9dCN8nwE2-sm-L8HfgBNfIjK</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2710973561</pqid></control><display><type>article</type><title>Role of thyroid hormones-induced oxidative stress on cardiovascular physiology</title><source>Elsevier ScienceDirect Journals</source><creator>Barreiro Arcos, María Laura</creator><creatorcontrib>Barreiro Arcos, María Laura</creatorcontrib><description>Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular homeostasis and are involved in the modulation of cardiac contractility, heart rate, diastolic function, systemic vascular resistance, and vasodilation. THs have actions on cardiovascular physiology through the activation or repression of target genes or the activation of intracellular signals through non-genomic mechanisms. Hyperthyroidism alters certain intracellular pathways involved in the preservation of the structure and functionality of the heart, causing relevant cardiovascular disorders. Reactive oxygen species (ROS) play an important role in the cardiovascular system, but the exacerbated increase in ROS caused by chronic hyperthyroidism together with regulation on the antioxidant system have been associated with the development of cardiovascular dysfunction. In this review, we analyze the role of THs-induced oxidative stress in the cellular and molecular changes that lead to cardiac dysfunction, as well as the effectiveness of antioxidant treatments in attenuating cardiac abnormalities developed during hyperthyroidism.
•Thyroid hormones exert effects on the heart through genomic and non-genomic actions.•Thyroid hormones induce oxidative stress in heart tissue.•ROS modulate signaling pathways that cause changes in cardiovascular physiology.•Antioxidants could attenuate the cardiac abnormalities induced by hyperthyroidism.</description><identifier>ISSN: 0304-4165</identifier><identifier>EISSN: 1872-8006</identifier><identifier>DOI: 10.1016/j.bbagen.2022.130239</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>Antioxidants ; Cardiac dysfunction ; heart ; heart rate ; homeostasis ; Hyperthyroidism ; Oxidative stress ; reactive oxygen species ; vasodilation</subject><ispartof>Biochimica et biophysica acta. General subjects, 2022-12, Vol.1866 (12), p.130239-130239, Article 130239</ispartof><rights>2022 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-6e5cc65a466ea1bf981b765218247f0e78f179edb688042ba3935faf9458c90c3</citedby><cites>FETCH-LOGICAL-c372t-6e5cc65a466ea1bf981b765218247f0e78f179edb688042ba3935faf9458c90c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S030441652200157X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids></links><search><creatorcontrib>Barreiro Arcos, María Laura</creatorcontrib><title>Role of thyroid hormones-induced oxidative stress on cardiovascular physiology</title><title>Biochimica et biophysica acta. General subjects</title><description>Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular homeostasis and are involved in the modulation of cardiac contractility, heart rate, diastolic function, systemic vascular resistance, and vasodilation. THs have actions on cardiovascular physiology through the activation or repression of target genes or the activation of intracellular signals through non-genomic mechanisms. Hyperthyroidism alters certain intracellular pathways involved in the preservation of the structure and functionality of the heart, causing relevant cardiovascular disorders. Reactive oxygen species (ROS) play an important role in the cardiovascular system, but the exacerbated increase in ROS caused by chronic hyperthyroidism together with regulation on the antioxidant system have been associated with the development of cardiovascular dysfunction. In this review, we analyze the role of THs-induced oxidative stress in the cellular and molecular changes that lead to cardiac dysfunction, as well as the effectiveness of antioxidant treatments in attenuating cardiac abnormalities developed during hyperthyroidism.
•Thyroid hormones exert effects on the heart through genomic and non-genomic actions.•Thyroid hormones induce oxidative stress in heart tissue.•ROS modulate signaling pathways that cause changes in cardiovascular physiology.•Antioxidants could attenuate the cardiac abnormalities induced by hyperthyroidism.</description><subject>Antioxidants</subject><subject>Cardiac dysfunction</subject><subject>heart</subject><subject>heart rate</subject><subject>homeostasis</subject><subject>Hyperthyroidism</subject><subject>Oxidative stress</subject><subject>reactive oxygen species</subject><subject>vasodilation</subject><issn>0304-4165</issn><issn>1872-8006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNqNkEtLxDAUhYMoOI7-AxddumlN0ua1EWTwBYOC6Dqk6c1Mhk4zJu3g_Hs71LV4N2fznQP3Q-ia4IJgwm83RV2bFXQFxZQWpMS0VCdoRqSgucSYn6IZLnGVV4Szc3SR0gaPxxSbodf30EIWXNavDzH4JluHuA0dpNx3zWChycK3b0zv95ClPkJKWegya2Ljw94kO7QmZrv1IfnQhtXhEp050ya4-s05-nx8-Fg858u3p5fF_TK3paB9zoFZy5mpOAdDaqckqQVnlEhaCYdBSEeEgqbmUuKK1qZUJXPGqYpJq7At5-hm2t3F8DVA6vXWJwttazoIQ9JU0JIQQZX4B0rwiDFORrSaUBtDShGc3kW_NfGgCdZH03qjJ9P6aFpPpsfa3VSD8eO9h6iT9dCN8nwE2-sm-L8HfgBNfIjK</recordid><startdate>202212</startdate><enddate>202212</enddate><creator>Barreiro Arcos, María Laura</creator><general>Elsevier B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>202212</creationdate><title>Role of thyroid hormones-induced oxidative stress on cardiovascular physiology</title><author>Barreiro Arcos, María Laura</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-6e5cc65a466ea1bf981b765218247f0e78f179edb688042ba3935faf9458c90c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antioxidants</topic><topic>Cardiac dysfunction</topic><topic>heart</topic><topic>heart rate</topic><topic>homeostasis</topic><topic>Hyperthyroidism</topic><topic>Oxidative stress</topic><topic>reactive oxygen species</topic><topic>vasodilation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Barreiro Arcos, María Laura</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Biochimica et biophysica acta. General subjects</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barreiro Arcos, María Laura</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of thyroid hormones-induced oxidative stress on cardiovascular physiology</atitle><jtitle>Biochimica et biophysica acta. General subjects</jtitle><date>2022-12</date><risdate>2022</risdate><volume>1866</volume><issue>12</issue><spage>130239</spage><epage>130239</epage><pages>130239-130239</pages><artnum>130239</artnum><issn>0304-4165</issn><eissn>1872-8006</eissn><abstract>Thyroid hormones (THs) play an essential role in the maintenance of cardiovascular homeostasis and are involved in the modulation of cardiac contractility, heart rate, diastolic function, systemic vascular resistance, and vasodilation. THs have actions on cardiovascular physiology through the activation or repression of target genes or the activation of intracellular signals through non-genomic mechanisms. Hyperthyroidism alters certain intracellular pathways involved in the preservation of the structure and functionality of the heart, causing relevant cardiovascular disorders. Reactive oxygen species (ROS) play an important role in the cardiovascular system, but the exacerbated increase in ROS caused by chronic hyperthyroidism together with regulation on the antioxidant system have been associated with the development of cardiovascular dysfunction. In this review, we analyze the role of THs-induced oxidative stress in the cellular and molecular changes that lead to cardiac dysfunction, as well as the effectiveness of antioxidant treatments in attenuating cardiac abnormalities developed during hyperthyroidism.
•Thyroid hormones exert effects on the heart through genomic and non-genomic actions.•Thyroid hormones induce oxidative stress in heart tissue.•ROS modulate signaling pathways that cause changes in cardiovascular physiology.•Antioxidants could attenuate the cardiac abnormalities induced by hyperthyroidism.</abstract><pub>Elsevier B.V</pub><doi>10.1016/j.bbagen.2022.130239</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0304-4165 |
ispartof | Biochimica et biophysica acta. General subjects, 2022-12, Vol.1866 (12), p.130239-130239, Article 130239 |
issn | 0304-4165 1872-8006 |
language | eng |
recordid | cdi_proquest_miscellaneous_2710973561 |
source | Elsevier ScienceDirect Journals |
subjects | Antioxidants Cardiac dysfunction heart heart rate homeostasis Hyperthyroidism Oxidative stress reactive oxygen species vasodilation |
title | Role of thyroid hormones-induced oxidative stress on cardiovascular physiology |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-18T20%3A50%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Role%20of%20thyroid%20hormones-induced%20oxidative%20stress%20on%20cardiovascular%20physiology&rft.jtitle=Biochimica%20et%20biophysica%20acta.%20General%20subjects&rft.au=Barreiro%20Arcos,%20Mar%C3%ADa%20Laura&rft.date=2022-12&rft.volume=1866&rft.issue=12&rft.spage=130239&rft.epage=130239&rft.pages=130239-130239&rft.artnum=130239&rft.issn=0304-4165&rft.eissn=1872-8006&rft_id=info:doi/10.1016/j.bbagen.2022.130239&rft_dat=%3Cproquest_cross%3E2710973561%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2710973561&rft_id=info:pmid/&rft_els_id=S030441652200157X&rfr_iscdi=true |