Anti‐tumour potential of PD‐L1/PD‐1 post‐translational modifications

The immune checkpoint programmed death receptor 1 (PD‐1) and programmed death ligand 1 (PD‐L1) are biologically important immunosuppressive molecules, and the PD‐L1/PD‐1‐mediated signalling pathway is currently considered one of the main mechanisms of tumour escape immune surveillance. PD‐L1 is high...

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Veröffentlicht in:	Immunology 2022-12, Vol.167 (4), p.471-481
Hauptverfasser:	Zhou, Shimeng, Zhu, Jinfeng, Xu, Jingwei, Gu, Bingzi, Zhao, Qiao, Luo, Congzhou, Gao, Zhoufeng, Chin, Y. Eugene, Cheng, Xiaju
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Apoptosis B7-H1 Antigen cancer research drug development Glycosylation Humans Immune checkpoint Immunosurveillance Immunotherapy Lymphocytes Lymphocytes T Neoplasms PD-L1 protein PD‐1 PD‐L1 Phosphorylation post‐translational modification Programmed Cell Death 1 Receptor Protein Processing, Post-Translational Receptors Signal transduction Signaling Translation Tumors tumour immunotherapy Ubiquitination
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