Recent progress toward developing axial chirality bioactive compounds

Atropisomers are stereoisomers with axial chirality arising from restricted rotation around a single bond. Lots of representatives of this class of axially chiral compounds exhibit remarkable biological properties for protein targets. This time-dependent chirality shows great potential for drug deve...

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Veröffentlicht in:	European journal of medicinal chemistry 2022-12, Vol.243, p.114700-114700, Article 114700
Hauptverfasser:	Wang, Zheyi, Meng, Liying, Liu, Xinxin, Zhang, Lingzi, Yu, Zongjiang, Wu, Guanzhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Atropisomer Axial chirality Axial drugs Biological activity Drug discovery
Online-Zugang:	Volltext
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