AATF Competitively Interacts with Nuclear AIF and Inhibits Parthanatos of Neurons in dMCAO/R and OGD/R Models

Ischemic stroke (IS) poses a heavy burden on the healthcare system, and revascularization is the most effective treatment. However, ischemia/reperfusion (I/R) injury, one main cause of revascularization complications, significantly hinders IS recovery. Unfortunately, none of the neuroprotectants tes...

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Veröffentlicht in:	Journal of molecular neuroscience 2022-11, Vol.72 (11), p.2218-2232
Hauptverfasser:	Xu, Wei, Hu, Zhen, Yin, Dou, Zeng, Yu-e, Zhang, Xiao-xiao, Jin, Wei, Ren, Chuan-cheng
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine diphosphate Apoptosis Apoptosis-inducing factor Biomedical and Life Sciences Biomedicine Cell Biology Cerebral blood flow Complications Deprivation DNA fragmentation Injuries Ischemia Neurochemistry Neurology Neurosciences Occlusion Proteomics Regulatory mechanisms (biology) Reperfusion Ribose Therapeutic targets Translocation
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