Solasonine alleviates high glucose‐induced podocyte injury through increasing Nrf2‐medicated inhibition of NLRP3 activation

The worldwide high prevalence of diabetic nephropathy is one of the common causes of renal failure in diabetic patients. Hyperglycemia‐caused podocyte injury is considered as a major contributor to diabetic kidney disease, accompanied by a chronic inflammatory condition. Pyroptosis, a characterized...

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Veröffentlicht in:	Drug development research 2022-11, Vol.83 (7), p.1697-1706
Hauptverfasser:	Zhang, Qianjin, Hu, Yichuan, Hu, Jin‐E, Zhang, Min
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticancer properties Antitumor agents Apoptosis Caspase Cell death Chemical compounds Cytokines Damage Diabetes Diabetes mellitus diabetic nephropathy Glucose Hyperglycemia Inflammation Injuries Interleukins Kidney diseases Nephropathy Nrf2/NLRP3 signaling Pathogenesis Pharmacology Pyroptosis Renal failure Signal transduction solasonine
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