Bone marrow‐derived mesenchymal stem cells alleviate paclitaxel‐induced mechanical allodynia in rats

Anticancer drug paclitaxel (PTX) frequently causes painful peripheral neuropathy; however, no medication has been shown to be effective in the treatment of this debilitating side effect. We aimed to investigate the efficacy of two different doses of allogeneic bone marrow‐derived mesenchymal stem ce...

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Veröffentlicht in:	Journal of biochemical and molecular toxicology 2022-12, Vol.36 (12), p.e23207-n/a
Hauptverfasser:	Sezer, Gulay, Yay, Arzu H., Sarica, Zeynep S., Gonen, Zeynep B., Onder, Gozde O., Alan, Aydın, Yilmaz, Secil, Saraymen, Berkay, Bahar, Dilek
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antitumor agents Bone Marrow Cytokines Damage localization Fluorescent dyes Fluorescent indicators Hyperalgesia - drug therapy Hyperalgesia - therapy Inflammation Interleukins Localization mechanical allodynia Mesenchymal Stem Cells Nerves neuropathic pain Paclitaxel Paclitaxel - toxicity Pain perception Peripheral neuropathy rat Rats Sciatic nerve Side effects Spinal cord Stem cell transplantation Stem cells Transplantation Tumor necrosis factor Tumor Necrosis Factor-alpha Tumor necrosis factor-TNF
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