Ivabradine treatment lowers blood pressure and promotes cardiac and renal protection in spontaneously hypertensive rats

Hypertension is linked to hyperpolarization-activated cyclic nucleotide-gated (HCN) function, expressed in excitable and non-excitable cells. Considering that the reduction in heart rate (HR) improves coronary perfusion and cardiac performance, ivabradine (IVA) emerged as an important drug for the t...

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Veröffentlicht in:	Life sciences (1973) 2022-11, Vol.308, p.120919-120919, Article 120919
Hauptverfasser:	Gomes, Fabiana A.R., Noronha, Sylvana I.S.R., Silva, Sabrina C.A., Machado-Júnior, Pedro A., Ostolin, Thais L.V.P., Chírico, Máira T.T., Ribeiro, Marcelo C., Reis, Alexandre B., Cangussú, Silvia D., Montano, Nicola, Silva, Valdo J.D., de Menezes, Rodrigo C.A., Silva, Fernanda C., Chianca-Jr, Deoclécio A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood pressure HCN channels Hypertension Ivabradine Renal and cardiac inflammatory response
Online-Zugang:	Volltext
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