Haloperidol Prevents Oxytosis/Ferroptosis by Targeting Lysosomal Ferrous Ions in a Manner Independent of Dopamine D2 and Sigma‑1 Receptors

Haloperidol is a widely used antipsychotic agent that exerts antipsychotic effects through a strong antagonism of dopamine D2 receptors. In addition, haloperidol is classified as a sigma-1 receptor (S1R) antagonist that prevents endogenous oxidative stress in cultured cells. However, pharmacological...

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Veröffentlicht in:	ACS chemical neuroscience 2022-09, Vol.13 (18), p.2719-2727
Hauptverfasser:	Hirata, Yoko, Oka, Kohei, Yamamoto, Shotaro, Watanabe, Hiroki, Oh-hashi, Kentaro, Hirayama, Tasuku, Nagasawa, Hideko, Takemori, Hiroshi, Furuta, Kyoji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - pharmacology Dopamine Ferroptosis Fluorescent Dyes Haloperidol - pharmacology Ions Iron - metabolism Lysosomes - metabolism Mice Neuroprotective Agents - pharmacology Reactive Oxygen Species - metabolism Receptors, Dopamine D2 Receptors, sigma Sigma-1 Receptor
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