Single-cell RNA sequencing reveals intra-tumoral heterogeneity of glioblastoma and a pro-tumor subset of tumor-associated macrophages characterized by EZH2 overexpression

Glioblastoma (GBM) is a highly heterogeneous disease with poor clinical outcome. To comprehensively dissect molecular landscape of GBM and heterogeneous distribution and potential role of Enhancer of zeste homolog 2 (EZH2) in tumor microenvironment (TME). Single-cell RNA sequencing (scRNA-seq) analy...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2022-12, Vol.1868 (12), p.166534-166534, Article 166534
Hauptverfasser:	Chen, Xiaoyong, Chen, Yue, Chen, Xiangrong, Wei, Penghui, Lin, Yuanxiang, Wu, Zanyi, Lin, Zhangya, Kang, Dezhi, Ding, Chenyu
Format:	Artikel
Sprache:	eng
Schlagworte:	EZH2 Glioblastoma Heterogeneity Macrophage Single-cell RNA sequencing
Online-Zugang:	Volltext
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