Development of a preoperative score to predict surgical difficulty in liver transplantation
A difficulty score to predict intraoperative surgical complexity in liver transplantation has never been developed. The aim of this study was to assess factors associated with a difficult liver transplant and develop a score to predict difficult surgery. All patients undergoing deceased donor whole...
Gespeichert in:
Veröffentlicht in: | Surgery 2022-11, Vol.172 (5), p.1529-1536 |
---|---|
Hauptverfasser: | , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 1536 |
---|---|
container_issue | 5 |
container_start_page | 1529 |
container_title | Surgery |
container_volume | 172 |
creator | Ausania, Fabio Borin, Alex Martinez-Perez, Aleix Blasi, Anabel Landi, Filippo Colmenero, Jordi Fuster, Josep Garcia-Valdecasas, Juan Carlos |
description | A difficulty score to predict intraoperative surgical complexity in liver transplantation has never been developed. The aim of this study was to assess factors associated with a difficult liver transplant and develop a score to predict difficult surgery.
All patients undergoing deceased donor whole liver transplantation from 2012 to 2019 at a single center were included. Estimated intraoperative blood loss (mL/kg) and surgery duration (skin-to-arterial reperfusion time) were used as surrogates of difficulty. Based on these variables, the study population was divided into 2 groups: high risk and standard risk of difficulty. Univariate and multivariate analyses were performed to identify predictors associated with a demanding liver transplantation and develop a difficulty score.
A total of 515 patients were included in the study population, and 101 (20%) were considered difficult operations. Patients with a higher risk of difficulty showed a significantly higher rate of Clavien-Dindo ≥III complications (50.5% vs 24.4%, P = .001) and a longer hospital stay (19 vs 16 days, P = .001). Preoperative factors associated with difficulty were retransplantation (odds ratio 4.34, P = .001), preoperative portal vein thrombosis (odds ratio 3.419, P = .001), previous upper abdominal surgery (odds ratio 2.161, P = .003), spontaneous bacterial peritonitis (odds ratio 1.985, P < .02), and prior variceal bleeding (odds ratio 1.401, P = .051). A 10-point difficulty score was created, showing a negative predictive value of 84% at 4 points.
Difficult liver transplantation surgery, as assessed by skin-to-arterial reperfusion time and estimated blood loss, is associated with worse perioperative outcomes. We developed a simple score with clinical preoperative variables that predicts difficult surgery, and therefore, it may help to optimize allocation policies and perioperative logistics. |
doi_str_mv | 10.1016/j.surg.2022.07.001 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2709739830</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0039606022004998</els_id><sourcerecordid>2709739830</sourcerecordid><originalsourceid>FETCH-LOGICAL-c333t-ebee6e00f58f78e438d34ed225cfde3ddaaeb87ca005d57f9c0756814270fb113</originalsourceid><addsrcrecordid>eNp9kE1LxDAQhoMouK7-AU85emmdNNumBS-yfsKCFz15CNlkIlm6TU3SBf-9KevZ08DwvPPxEHLNoGTAmttdGafwVVZQVSWIEoCdkAWreVUI3rBTsgDgXdFAA-fkIsYdAHQr1i7I5wMesPfjHodEvaWKjgH9iEEld0AatQ9Ik5-7xulE5zVOq54aZ63TU59-qBton-FAU1BDHHs1pJz2wyU5s6qPePVXl-Tj6fF9_VJs3p5f1_ebQnPOU4FbxAYBbN1a0eKKt4av0FRVra1BboxSuG2FVgC1qYXtNIi6admqEmC3jPEluTnOHYP_njAmuXdRY58PQT9FmblO8K7lkNHqiOrgYwxo5RjcXoUfyUDOJuVOzi_K2aQEIbPJHLo7hjA_cXAYZNQOB52NBNRJGu_-i_8CZxx_LA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2709739830</pqid></control><display><type>article</type><title>Development of a preoperative score to predict surgical difficulty in liver transplantation</title><source>Access via ScienceDirect (Elsevier)</source><creator>Ausania, Fabio ; Borin, Alex ; Martinez-Perez, Aleix ; Blasi, Anabel ; Landi, Filippo ; Colmenero, Jordi ; Fuster, Josep ; Garcia-Valdecasas, Juan Carlos</creator><creatorcontrib>Ausania, Fabio ; Borin, Alex ; Martinez-Perez, Aleix ; Blasi, Anabel ; Landi, Filippo ; Colmenero, Jordi ; Fuster, Josep ; Garcia-Valdecasas, Juan Carlos</creatorcontrib><description>A difficulty score to predict intraoperative surgical complexity in liver transplantation has never been developed. The aim of this study was to assess factors associated with a difficult liver transplant and develop a score to predict difficult surgery.
All patients undergoing deceased donor whole liver transplantation from 2012 to 2019 at a single center were included. Estimated intraoperative blood loss (mL/kg) and surgery duration (skin-to-arterial reperfusion time) were used as surrogates of difficulty. Based on these variables, the study population was divided into 2 groups: high risk and standard risk of difficulty. Univariate and multivariate analyses were performed to identify predictors associated with a demanding liver transplantation and develop a difficulty score.
A total of 515 patients were included in the study population, and 101 (20%) were considered difficult operations. Patients with a higher risk of difficulty showed a significantly higher rate of Clavien-Dindo ≥III complications (50.5% vs 24.4%, P = .001) and a longer hospital stay (19 vs 16 days, P = .001). Preoperative factors associated with difficulty were retransplantation (odds ratio 4.34, P = .001), preoperative portal vein thrombosis (odds ratio 3.419, P = .001), previous upper abdominal surgery (odds ratio 2.161, P = .003), spontaneous bacterial peritonitis (odds ratio 1.985, P < .02), and prior variceal bleeding (odds ratio 1.401, P = .051). A 10-point difficulty score was created, showing a negative predictive value of 84% at 4 points.
Difficult liver transplantation surgery, as assessed by skin-to-arterial reperfusion time and estimated blood loss, is associated with worse perioperative outcomes. We developed a simple score with clinical preoperative variables that predicts difficult surgery, and therefore, it may help to optimize allocation policies and perioperative logistics.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2022.07.001</identifier><language>eng</language><publisher>Elsevier Inc</publisher><ispartof>Surgery, 2022-11, Vol.172 (5), p.1529-1536</ispartof><rights>2022 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c333t-ebee6e00f58f78e438d34ed225cfde3ddaaeb87ca005d57f9c0756814270fb113</citedby><cites>FETCH-LOGICAL-c333t-ebee6e00f58f78e438d34ed225cfde3ddaaeb87ca005d57f9c0756814270fb113</cites><orcidid>0000-0001-8891-2546</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.surg.2022.07.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>Ausania, Fabio</creatorcontrib><creatorcontrib>Borin, Alex</creatorcontrib><creatorcontrib>Martinez-Perez, Aleix</creatorcontrib><creatorcontrib>Blasi, Anabel</creatorcontrib><creatorcontrib>Landi, Filippo</creatorcontrib><creatorcontrib>Colmenero, Jordi</creatorcontrib><creatorcontrib>Fuster, Josep</creatorcontrib><creatorcontrib>Garcia-Valdecasas, Juan Carlos</creatorcontrib><title>Development of a preoperative score to predict surgical difficulty in liver transplantation</title><title>Surgery</title><description>A difficulty score to predict intraoperative surgical complexity in liver transplantation has never been developed. The aim of this study was to assess factors associated with a difficult liver transplant and develop a score to predict difficult surgery.
All patients undergoing deceased donor whole liver transplantation from 2012 to 2019 at a single center were included. Estimated intraoperative blood loss (mL/kg) and surgery duration (skin-to-arterial reperfusion time) were used as surrogates of difficulty. Based on these variables, the study population was divided into 2 groups: high risk and standard risk of difficulty. Univariate and multivariate analyses were performed to identify predictors associated with a demanding liver transplantation and develop a difficulty score.
A total of 515 patients were included in the study population, and 101 (20%) were considered difficult operations. Patients with a higher risk of difficulty showed a significantly higher rate of Clavien-Dindo ≥III complications (50.5% vs 24.4%, P = .001) and a longer hospital stay (19 vs 16 days, P = .001). Preoperative factors associated with difficulty were retransplantation (odds ratio 4.34, P = .001), preoperative portal vein thrombosis (odds ratio 3.419, P = .001), previous upper abdominal surgery (odds ratio 2.161, P = .003), spontaneous bacterial peritonitis (odds ratio 1.985, P < .02), and prior variceal bleeding (odds ratio 1.401, P = .051). A 10-point difficulty score was created, showing a negative predictive value of 84% at 4 points.
Difficult liver transplantation surgery, as assessed by skin-to-arterial reperfusion time and estimated blood loss, is associated with worse perioperative outcomes. We developed a simple score with clinical preoperative variables that predicts difficult surgery, and therefore, it may help to optimize allocation policies and perioperative logistics.</description><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouK7-AU85emmdNNumBS-yfsKCFz15CNlkIlm6TU3SBf-9KevZ08DwvPPxEHLNoGTAmttdGafwVVZQVSWIEoCdkAWreVUI3rBTsgDgXdFAA-fkIsYdAHQr1i7I5wMesPfjHodEvaWKjgH9iEEld0AatQ9Ik5-7xulE5zVOq54aZ63TU59-qBton-FAU1BDHHs1pJz2wyU5s6qPePVXl-Tj6fF9_VJs3p5f1_ebQnPOU4FbxAYBbN1a0eKKt4av0FRVra1BboxSuG2FVgC1qYXtNIi6admqEmC3jPEluTnOHYP_njAmuXdRY58PQT9FmblO8K7lkNHqiOrgYwxo5RjcXoUfyUDOJuVOzi_K2aQEIbPJHLo7hjA_cXAYZNQOB52NBNRJGu_-i_8CZxx_LA</recordid><startdate>202211</startdate><enddate>202211</enddate><creator>Ausania, Fabio</creator><creator>Borin, Alex</creator><creator>Martinez-Perez, Aleix</creator><creator>Blasi, Anabel</creator><creator>Landi, Filippo</creator><creator>Colmenero, Jordi</creator><creator>Fuster, Josep</creator><creator>Garcia-Valdecasas, Juan Carlos</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8891-2546</orcidid></search><sort><creationdate>202211</creationdate><title>Development of a preoperative score to predict surgical difficulty in liver transplantation</title><author>Ausania, Fabio ; Borin, Alex ; Martinez-Perez, Aleix ; Blasi, Anabel ; Landi, Filippo ; Colmenero, Jordi ; Fuster, Josep ; Garcia-Valdecasas, Juan Carlos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c333t-ebee6e00f58f78e438d34ed225cfde3ddaaeb87ca005d57f9c0756814270fb113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ausania, Fabio</creatorcontrib><creatorcontrib>Borin, Alex</creatorcontrib><creatorcontrib>Martinez-Perez, Aleix</creatorcontrib><creatorcontrib>Blasi, Anabel</creatorcontrib><creatorcontrib>Landi, Filippo</creatorcontrib><creatorcontrib>Colmenero, Jordi</creatorcontrib><creatorcontrib>Fuster, Josep</creatorcontrib><creatorcontrib>Garcia-Valdecasas, Juan Carlos</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ausania, Fabio</au><au>Borin, Alex</au><au>Martinez-Perez, Aleix</au><au>Blasi, Anabel</au><au>Landi, Filippo</au><au>Colmenero, Jordi</au><au>Fuster, Josep</au><au>Garcia-Valdecasas, Juan Carlos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of a preoperative score to predict surgical difficulty in liver transplantation</atitle><jtitle>Surgery</jtitle><date>2022-11</date><risdate>2022</risdate><volume>172</volume><issue>5</issue><spage>1529</spage><epage>1536</epage><pages>1529-1536</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><abstract>A difficulty score to predict intraoperative surgical complexity in liver transplantation has never been developed. The aim of this study was to assess factors associated with a difficult liver transplant and develop a score to predict difficult surgery.
All patients undergoing deceased donor whole liver transplantation from 2012 to 2019 at a single center were included. Estimated intraoperative blood loss (mL/kg) and surgery duration (skin-to-arterial reperfusion time) were used as surrogates of difficulty. Based on these variables, the study population was divided into 2 groups: high risk and standard risk of difficulty. Univariate and multivariate analyses were performed to identify predictors associated with a demanding liver transplantation and develop a difficulty score.
A total of 515 patients were included in the study population, and 101 (20%) were considered difficult operations. Patients with a higher risk of difficulty showed a significantly higher rate of Clavien-Dindo ≥III complications (50.5% vs 24.4%, P = .001) and a longer hospital stay (19 vs 16 days, P = .001). Preoperative factors associated with difficulty were retransplantation (odds ratio 4.34, P = .001), preoperative portal vein thrombosis (odds ratio 3.419, P = .001), previous upper abdominal surgery (odds ratio 2.161, P = .003), spontaneous bacterial peritonitis (odds ratio 1.985, P < .02), and prior variceal bleeding (odds ratio 1.401, P = .051). A 10-point difficulty score was created, showing a negative predictive value of 84% at 4 points.
Difficult liver transplantation surgery, as assessed by skin-to-arterial reperfusion time and estimated blood loss, is associated with worse perioperative outcomes. We developed a simple score with clinical preoperative variables that predicts difficult surgery, and therefore, it may help to optimize allocation policies and perioperative logistics.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.surg.2022.07.001</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-8891-2546</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0039-6060 |
ispartof | Surgery, 2022-11, Vol.172 (5), p.1529-1536 |
issn | 0039-6060 1532-7361 |
language | eng |
recordid | cdi_proquest_miscellaneous_2709739830 |
source | Access via ScienceDirect (Elsevier) |
title | Development of a preoperative score to predict surgical difficulty in liver transplantation |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T08%3A14%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Development%20of%20a%20preoperative%20score%20to%20predict%20surgical%20difficulty%20in%20liver%20transplantation&rft.jtitle=Surgery&rft.au=Ausania,%20Fabio&rft.date=2022-11&rft.volume=172&rft.issue=5&rft.spage=1529&rft.epage=1536&rft.pages=1529-1536&rft.issn=0039-6060&rft.eissn=1532-7361&rft_id=info:doi/10.1016/j.surg.2022.07.001&rft_dat=%3Cproquest_cross%3E2709739830%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2709739830&rft_id=info:pmid/&rft_els_id=S0039606022004998&rfr_iscdi=true |