Evaluation of genetic instability, oxidative stress, and metabolism-related gene polymorphisms in workers exposed to waste anesthetic gases
Professionals who work in operating rooms (ORs) may be exposed daily to waste anesthetic gases (WAGs) due to the use of inhalational anesthetics. Considering the controversial findings related to genetic damage and redox status in addition to a lack of knowledge about the effect of polymorphisms in...
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| Veröffentlicht in: | Environmental science and pollution research international 2023-01, Vol.30 (4), p.9609-9623 |
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| creator | Silva, Mariane A. P. Figueiredo, Drielle B. S. Lara, Juliana R. Paschoalinotte, Eloisa E. Braz, Leandro G. Braz, Mariana G. |
| description | Professionals who work in operating rooms (ORs) may be exposed daily to waste anesthetic gases (WAGs) due to the use of inhalational anesthetics. Considering the controversial findings related to genetic damage and redox status in addition to a lack of knowledge about the effect of polymorphisms in genes related to phase I and II detoxification upon occupational exposure to WAGs, this cross-sectional study is the first to jointly evaluate biomarkers of genetic instability, oxidative stress, and susceptibility genes in professionals occupationally exposed to high trace amounts of halogenated (≥ 7 ppm) and nitrous oxide (165 ppm) anesthetics in ORs and in individuals not exposed to WAGs (control group). Elevated rates of buccal micronucleus (MN) and nuclear bud (NBUD) were observed in the exposure group and in professionals exposed aged more than 30 years. Exposed males showed a higher antioxidant capacity, as determined by the ferric reducing antioxidant power (FRAP), than exposed females; exposed females had higher frequencies of MN and NBUD than nonexposed females. Genetic instability (MN) was observed in professionals with greater weekly WAG exposure, and those exposed for longer durations (years) exhibited oxidative stress (increased lipid peroxidation and decreased FRAP). Polymorphisms in metabolic genes (cytochrome P450 2E1 (
CYP2E1
) and glutathione S-transferases (
GSTs
)) did not exert an effect, except for the effects of the
GSTP1
(rs1695) AG/GG polymorphism on FRAP (both groups) and
GSTP1
AG/GG and
GSTT1
null polymorphisms, which were associated with greater FRAP values in exposed males. Minimizing WAG exposure is necessary to reduce impacts on healthcare workers. |
| doi_str_mv | 10.1007/s11356-022-22765-8 |
| format | Article |
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CYP2E1
) and glutathione S-transferases (
GSTs
)) did not exert an effect, except for the effects of the
GSTP1
(rs1695) AG/GG polymorphism on FRAP (both groups) and
GSTP1
AG/GG and
GSTT1
null polymorphisms, which were associated with greater FRAP values in exposed males. Minimizing WAG exposure is necessary to reduce impacts on healthcare workers.</description><identifier>ISSN: 1614-7499</identifier><identifier>EISSN: 1614-7499</identifier><identifier>DOI: 10.1007/s11356-022-22765-8</identifier><identifier>PMID: 36057057</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Anesthetics, Inhalation ; Antioxidants ; Aquatic Pollution ; Atmospheric Protection/Air Quality Control/Air Pollution ; Cross-Sectional Studies ; DNA Damage ; Earth and Environmental Science ; Ecotoxicology ; Environment ; Environmental Chemistry ; Environmental Health ; Female ; Glutathione Transferase - genetics ; Humans ; Male ; Occupational Exposure - analysis ; Oxidative Stress ; Polymorphism, Genetic ; Research Article ; Waste Water Technology ; Water Management ; Water Pollution Control</subject><ispartof>Environmental science and pollution research international, 2023-01, Vol.30 (4), p.9609-9623</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c277t-a1de88893b4ff9018f76ddb5631c64778dbc83533f674c68eec03d3227a992493</citedby><cites>FETCH-LOGICAL-c277t-a1de88893b4ff9018f76ddb5631c64778dbc83533f674c68eec03d3227a992493</cites><orcidid>0000-0003-4413-226X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11356-022-22765-8$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11356-022-22765-8$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36057057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Silva, Mariane A. P.</creatorcontrib><creatorcontrib>Figueiredo, Drielle B. S.</creatorcontrib><creatorcontrib>Lara, Juliana R.</creatorcontrib><creatorcontrib>Paschoalinotte, Eloisa E.</creatorcontrib><creatorcontrib>Braz, Leandro G.</creatorcontrib><creatorcontrib>Braz, Mariana G.</creatorcontrib><title>Evaluation of genetic instability, oxidative stress, and metabolism-related gene polymorphisms in workers exposed to waste anesthetic gases</title><title>Environmental science and pollution research international</title><addtitle>Environ Sci Pollut Res</addtitle><addtitle>Environ Sci Pollut Res Int</addtitle><description>Professionals who work in operating rooms (ORs) may be exposed daily to waste anesthetic gases (WAGs) due to the use of inhalational anesthetics. Considering the controversial findings related to genetic damage and redox status in addition to a lack of knowledge about the effect of polymorphisms in genes related to phase I and II detoxification upon occupational exposure to WAGs, this cross-sectional study is the first to jointly evaluate biomarkers of genetic instability, oxidative stress, and susceptibility genes in professionals occupationally exposed to high trace amounts of halogenated (≥ 7 ppm) and nitrous oxide (165 ppm) anesthetics in ORs and in individuals not exposed to WAGs (control group). Elevated rates of buccal micronucleus (MN) and nuclear bud (NBUD) were observed in the exposure group and in professionals exposed aged more than 30 years. Exposed males showed a higher antioxidant capacity, as determined by the ferric reducing antioxidant power (FRAP), than exposed females; exposed females had higher frequencies of MN and NBUD than nonexposed females. Genetic instability (MN) was observed in professionals with greater weekly WAG exposure, and those exposed for longer durations (years) exhibited oxidative stress (increased lipid peroxidation and decreased FRAP). Polymorphisms in metabolic genes (cytochrome P450 2E1 (
CYP2E1
) and glutathione S-transferases (
GSTs
)) did not exert an effect, except for the effects of the
GSTP1
(rs1695) AG/GG polymorphism on FRAP (both groups) and
GSTP1
AG/GG and
GSTT1
null polymorphisms, which were associated with greater FRAP values in exposed males. Minimizing WAG exposure is necessary to reduce impacts on healthcare workers.</description><subject>Anesthetics, Inhalation</subject><subject>Antioxidants</subject><subject>Aquatic Pollution</subject><subject>Atmospheric Protection/Air Quality Control/Air Pollution</subject><subject>Cross-Sectional Studies</subject><subject>DNA Damage</subject><subject>Earth and Environmental Science</subject><subject>Ecotoxicology</subject><subject>Environment</subject><subject>Environmental Chemistry</subject><subject>Environmental Health</subject><subject>Female</subject><subject>Glutathione Transferase - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Occupational Exposure - analysis</subject><subject>Oxidative Stress</subject><subject>Polymorphism, Genetic</subject><subject>Research Article</subject><subject>Waste Water Technology</subject><subject>Water Management</subject><subject>Water Pollution Control</subject><issn>1614-7499</issn><issn>1614-7499</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kctu1TAQhi0EoqXwAiyQlywa8CXxZYmqcpEqsYG15cSTU5ckDh6n7XmGvjTmnIJYIVmypfn-f8bzE_Kas3ecMf0eOZedapgQjRBadY15Qk654m2jW2uf_vM-IS8QbxgTzAr9nJxIxTpdzyl5uLz10-ZLTAtNI93BAiUONC5YfB-nWPbnNN3HUIlboFgyIJ5TvwQ6QyXSFHFuMky-QDio6Zqm_Zzyel0rWI3oXco_ICOF-zVhpUqidx4LVBfAcn3ot_MI-JI8G_2E8OrxPiPfP15-u_jcXH399OXiw1UzCK1L43kAY4yVfTuOlnEzahVC3ynJB9VqbUI_GNlJOSrdDsoADEwGWVfkrRWtlWfk7dF3zennVmdwc8QBpqkOlDZ0QjOrpWVMVlQc0SEnxAyjW3Ocfd47ztzvENwxBFdDcIcQnKmiN4_-Wz9D-Cv5s_UKyCOAtbTsILubtOWl_vl_tr8AKDWVhg</recordid><startdate>20230101</startdate><enddate>20230101</enddate><creator>Silva, Mariane A. P.</creator><creator>Figueiredo, Drielle B. S.</creator><creator>Lara, Juliana R.</creator><creator>Paschoalinotte, Eloisa E.</creator><creator>Braz, Leandro G.</creator><creator>Braz, Mariana G.</creator><general>Springer Berlin Heidelberg</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4413-226X</orcidid></search><sort><creationdate>20230101</creationdate><title>Evaluation of genetic instability, oxidative stress, and metabolism-related gene polymorphisms in workers exposed to waste anesthetic gases</title><author>Silva, Mariane A. P. ; Figueiredo, Drielle B. S. ; Lara, Juliana R. ; Paschoalinotte, Eloisa E. ; Braz, Leandro G. ; Braz, Mariana G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c277t-a1de88893b4ff9018f76ddb5631c64778dbc83533f674c68eec03d3227a992493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Anesthetics, Inhalation</topic><topic>Antioxidants</topic><topic>Aquatic Pollution</topic><topic>Atmospheric Protection/Air Quality Control/Air Pollution</topic><topic>Cross-Sectional Studies</topic><topic>DNA Damage</topic><topic>Earth and Environmental Science</topic><topic>Ecotoxicology</topic><topic>Environment</topic><topic>Environmental Chemistry</topic><topic>Environmental Health</topic><topic>Female</topic><topic>Glutathione Transferase - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Occupational Exposure - analysis</topic><topic>Oxidative Stress</topic><topic>Polymorphism, Genetic</topic><topic>Research Article</topic><topic>Waste Water Technology</topic><topic>Water Management</topic><topic>Water Pollution Control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Mariane A. P.</creatorcontrib><creatorcontrib>Figueiredo, Drielle B. S.</creatorcontrib><creatorcontrib>Lara, Juliana R.</creatorcontrib><creatorcontrib>Paschoalinotte, Eloisa E.</creatorcontrib><creatorcontrib>Braz, Leandro G.</creatorcontrib><creatorcontrib>Braz, Mariana G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Environmental science and pollution research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Mariane A. P.</au><au>Figueiredo, Drielle B. S.</au><au>Lara, Juliana R.</au><au>Paschoalinotte, Eloisa E.</au><au>Braz, Leandro G.</au><au>Braz, Mariana G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of genetic instability, oxidative stress, and metabolism-related gene polymorphisms in workers exposed to waste anesthetic gases</atitle><jtitle>Environmental science and pollution research international</jtitle><stitle>Environ Sci Pollut Res</stitle><addtitle>Environ Sci Pollut Res Int</addtitle><date>2023-01-01</date><risdate>2023</risdate><volume>30</volume><issue>4</issue><spage>9609</spage><epage>9623</epage><pages>9609-9623</pages><issn>1614-7499</issn><eissn>1614-7499</eissn><abstract>Professionals who work in operating rooms (ORs) may be exposed daily to waste anesthetic gases (WAGs) due to the use of inhalational anesthetics. Considering the controversial findings related to genetic damage and redox status in addition to a lack of knowledge about the effect of polymorphisms in genes related to phase I and II detoxification upon occupational exposure to WAGs, this cross-sectional study is the first to jointly evaluate biomarkers of genetic instability, oxidative stress, and susceptibility genes in professionals occupationally exposed to high trace amounts of halogenated (≥ 7 ppm) and nitrous oxide (165 ppm) anesthetics in ORs and in individuals not exposed to WAGs (control group). Elevated rates of buccal micronucleus (MN) and nuclear bud (NBUD) were observed in the exposure group and in professionals exposed aged more than 30 years. Exposed males showed a higher antioxidant capacity, as determined by the ferric reducing antioxidant power (FRAP), than exposed females; exposed females had higher frequencies of MN and NBUD than nonexposed females. Genetic instability (MN) was observed in professionals with greater weekly WAG exposure, and those exposed for longer durations (years) exhibited oxidative stress (increased lipid peroxidation and decreased FRAP). Polymorphisms in metabolic genes (cytochrome P450 2E1 (
CYP2E1
) and glutathione S-transferases (
GSTs
)) did not exert an effect, except for the effects of the
GSTP1
(rs1695) AG/GG polymorphism on FRAP (both groups) and
GSTP1
AG/GG and
GSTT1
null polymorphisms, which were associated with greater FRAP values in exposed males. Minimizing WAG exposure is necessary to reduce impacts on healthcare workers.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>36057057</pmid><doi>10.1007/s11356-022-22765-8</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-4413-226X</orcidid></addata></record> |
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| subjects | Anesthetics, Inhalation Antioxidants Aquatic Pollution Atmospheric Protection/Air Quality Control/Air Pollution Cross-Sectional Studies DNA Damage Earth and Environmental Science Ecotoxicology Environment Environmental Chemistry Environmental Health Female Glutathione Transferase - genetics Humans Male Occupational Exposure - analysis Oxidative Stress Polymorphism, Genetic Research Article Waste Water Technology Water Management Water Pollution Control |
| title | Evaluation of genetic instability, oxidative stress, and metabolism-related gene polymorphisms in workers exposed to waste anesthetic gases |
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