Glucose metabolism enhancement by 10-hydroxy-2-decenoic acid via the PI3K/AKT signaling pathway in high-fat-diet/streptozotocin induced type 2 diabetic mice

10-Hydroxy-2-decenoic acid (10-HDA) is a principal active ingredients of royal jelly. Several recent studies demonstrated that 10-HDA has potential anti-type 2 diabetes mellitus (T2DM) properties. To evaluate the anti-T2DM effect of 10-HDA and explore its underlying molecular mechanisms, we used hig...

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Veröffentlicht in:	Food & function 2022-10, Vol.13 (19), p.9931-9946
Hauptverfasser:	Hu, Xiyi, Liu, Zhenguo, Lu, Yuntao, Chi, Xuepeng, Han, Kai, Wang, Hongfang, Wang, Ying, Ma, Lanting, Xu, Baohua
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Biomarkers Blood glucose Body weight Catalase Degeneration Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diet Esters Fatty acids Glucose Glucose metabolism Glutathione Glutathione peroxidase High fat diet Insulin Interleukin 6 Lipid peroxidation Lipids Liver Metabolomics Molecular modelling NF-κB protein Nuclear transport Peroxidase Peroxidation Royal jelly Signal transduction Signaling Streptozocin Superoxide dismutase Translocation Tumor necrosis factor-α
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