SIN3‐HDAC complex‐associated factor, a chromatin remodelling gene located in the 12p amplicon, is a potential germ cell tumour‐specific oncogene

A genetic hallmark of malignant germ cell tumours (GCTs) is isochromosome 12p, but oncogenes located in 12p that are specifically expressed in GCT have not yet been identified. SIN3‐HDAC complex‐associated factor (SINHCAF) is a subunit of the Sin3/histone deacetylase (HDAC) complex, and it defines a...

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Veröffentlicht in:	The Journal of pathology 2022-12, Vol.258 (4), p.353-365
Hauptverfasser:	Jhuang, Yu‐Ling, Yang, Chun‐Wei, Tseng, Yu‐Fen, Hsu, Chia‐Lang, Li, Huei‐Ying, Yuan, Ray‐Hwang, Jeng, Yung‐Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	belinostat Cell differentiation Cell migration Cell proliferation Cell self-renewal Chromatin Assembly and Disassembly - genetics Chromatin remodeling Chromosome 12 Chromosomes, Human, Pair 12 - genetics differentiation Embryo cells germ cell tumour Histone deacetylase histone deacetylase inhibitor Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - genetics Histone Deacetylases - metabolism Humans Hybridization In Situ Hybridization, Fluorescence isochromosome 12p Male Malignancy Neoplasms, Germ Cell and Embryonal - genetics Oncogenes panobinostat SINHCAF Stem cell transplantation Stem cells Testicular cancer testicular tumour Tumors
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