Exome sequencing and functional analyses revealed CETN1 variants leads to impaired cell division and male fertility

Human spermatogenesis requires an orchestrated expression of numerous genes in various germ cell subtypes. Therefore, the genetic landscape of male infertility is highly complex. Known genetic factors alone account for at least 15% of male infertility. However, ~40% of infertile men remain undiagnos...

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Veröffentlicht in:	Human molecular genetics 2023-01, Vol.32 (4), p.533-542
Hauptverfasser:	Sudhakar, Digumarthi V S, Phanindranath, Regur, Jaishankar, Shveta, Ramani, Anand, Kalamkar, Kaustubh P, Kumar, Umesh, Pawar, Asmita D, Dada, Rima, Singh, Rajender, Gupta, Nalini J, Deenadayal, Mamata, Tolani, Aarti Deenadayal, Sharma, Yogendra, Anand, Anuranjan, Gopalakrishnan, Jay, Thangaraj, Kumarasamy
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium-Binding Proteins - genetics Cell Cycle Proteins - genetics Cell Division Cytoskeletal Proteins - genetics Exome Sequencing Fertility - genetics Humans Infertility, Male - genetics Male Mice Spermatogenesis - genetics
Online-Zugang:	Volltext
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