A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV‑1 Infected Cells

Although current antiretroviral therapy can control HIV-1 replication and prevent disease progression, it is not curative. Identifying mechanisms that can lead to eradication of persistent viral reservoirs in people living with HIV-1 (PLWH) remains an outstanding challenge to achieving cure. Utilizi...

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Veröffentlicht in:	ACS chemical biology 2022-09, Vol.17 (9), p.2595-2604
Hauptverfasser:	Moore, Keith P., Schwaid, Adam G., Tudor, Matthew, Park, Sangho, Beshore, Douglas C., Converso, Antonella, Shipe, William D., Anand, Rajan, Lan, Ping, Moningka, Remond, Rothman, Deborah M., Sun, Wanying, Chi, An, Cornella-Taracido, Ivan, Adam, Gregory C., Bahnck-Teets, Carolyn, Carroll, Steven S., Fay, John F., Goh, Shih Lin, Lusen, Jeffrey, Quan, Shuo, Rodriguez, Silveria, Xu, Min, Andrews, Christine L., Song, Cheng, Filzen, Tracey, Li, Jing, Hollenstein, Kaspar, Klein, Daniel J., Lammens, Alfred, Lim, U-Ming, Fang, Zhiyu, McHale, Carolyn, Li, Yuan, Lu, Meiqing, Diamond, Tracy L., Howell, Bonnie J., Zuck, Paul, Balibar, Carl J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Benzoxazines CARD Signaling Adaptor Proteins - metabolism Cyclopropanes Dipeptidyl-Peptidases and Tripeptidyl-Peptidases - metabolism HIV Infections - drug therapy HIV-1 - metabolism Humans Inflammasomes - metabolism Leukocytes, Mononuclear Neoplasm Proteins - metabolism
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