Predictors of in-hospital mortality in HIV-infected patients with COVID-19
Underlying immunodeficiency is associated with severe COVID-19, but the prognosis of persons with human immunodeficiency virus (HIV) (PWH) with COVID-19 is under debate. Aim: assessment of the mortality rate and major determinants of death in HIV-infected patients hospitalized with COVID-19 in Spain...
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| Veröffentlicht in: | QJM : An International Journal of Medicine 2023-02, Vol.116 (1), p.57-62 |
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| creator | Moreno-Torres, V de Mendoza, C Martínez-Urbistondo, M Mills, P Treviño, A de la Fuente, S Díaz de Santiago, A Calderón-Parra, J Pintos-Pascual, I Corpas, M Soriano, V |
| description | Underlying immunodeficiency is associated with severe COVID-19, but the prognosis of persons with human immunodeficiency virus (HIV) (PWH) with COVID-19 is under debate. Aim: assessment of the mortality rate and major determinants of death in HIV-infected patients hospitalized with COVID-19 in Spain before vaccine availability. Design: Retrospective nationwide public database analysis.
Nationwide, retrospective, observational analysis of all hospitalizations with COVID-19 during year 2020 in Spain. Stratification was made according to HIV status. The National Registry of Hospital Discharges was used with the ICD-10 coding list.
A total of 117 694 adults were hospitalized with COVID-19 during 2020. Only 234 (0.2%) were HIV-positives. More than 95% were on antiretroviral therapy. Compared to HIV-negatives, PWH were younger (mean age 53.2 vs. 66.5 years old; P |
| doi_str_mv | 10.1093/qjmed/hcac215 |
| format | Article |
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Nationwide, retrospective, observational analysis of all hospitalizations with COVID-19 during year 2020 in Spain. Stratification was made according to HIV status. The National Registry of Hospital Discharges was used with the ICD-10 coding list.
A total of 117 694 adults were hospitalized with COVID-19 during 2020. Only 234 (0.2%) were HIV-positives. More than 95% were on antiretroviral therapy. Compared to HIV-negatives, PWH were younger (mean age 53.2 vs. 66.5 years old; P<0.001) and more frequently male (74.8% vs. 56.6%; P<0.001). Most co-morbidities predisposing to severe COVID-19 (diabetes, hypertension, dementia and cardiovascular disease) were more frequent in HIV-negatives. In contrast, the rate of baseline liver disease was over 6-fold higher in PWH (27.4% vs. 4.4%; P<0.001). In-hospital mortality was lower in PWH (9.4% vs. 16%; P=0.004). In multivariate analysis, older age, dementia and especially advanced liver disease (relative risk (RR): 7.6) were the major determinants of death in PWH hospitalized with COVID-19.
HIV-infected patients hospitalized in Spain with COVID-19 during 2020 had better survival than HIV-negatives, most likely explained by younger age and lower rate of co-morbidities. However, advanced liver disease was a major predictor of death in PWH hospitalized with COVID-19.</description><identifier>ISSN: 1460-2725</identifier><identifier>EISSN: 1460-2393</identifier><identifier>DOI: 10.1093/qjmed/hcac215</identifier><identifier>PMID: 36047831</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; COVID-19 - complications ; Dementia ; Female ; HIV ; HIV Infections - complications ; HIV Infections - epidemiology ; Hospital Mortality ; Humans ; Male ; Middle Aged ; Retrospective Studies</subject><ispartof>QJM : An International Journal of Medicine, 2023-02, Vol.116 (1), p.57-62</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the Association of Physicians. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c332t-163bf91f4b18f2acd5cb9ba6472c7e4c49264819eb8bae7b142aaaee7bd1f4133</citedby><cites>FETCH-LOGICAL-c332t-163bf91f4b18f2acd5cb9ba6472c7e4c49264819eb8bae7b142aaaee7bd1f4133</cites><orcidid>0000-0002-4624-5199</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36047831$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno-Torres, V</creatorcontrib><creatorcontrib>de Mendoza, C</creatorcontrib><creatorcontrib>Martínez-Urbistondo, M</creatorcontrib><creatorcontrib>Mills, P</creatorcontrib><creatorcontrib>Treviño, A</creatorcontrib><creatorcontrib>de la Fuente, S</creatorcontrib><creatorcontrib>Díaz de Santiago, A</creatorcontrib><creatorcontrib>Calderón-Parra, J</creatorcontrib><creatorcontrib>Pintos-Pascual, I</creatorcontrib><creatorcontrib>Corpas, M</creatorcontrib><creatorcontrib>Soriano, V</creatorcontrib><title>Predictors of in-hospital mortality in HIV-infected patients with COVID-19</title><title>QJM : An International Journal of Medicine</title><addtitle>QJM</addtitle><description>Underlying immunodeficiency is associated with severe COVID-19, but the prognosis of persons with human immunodeficiency virus (HIV) (PWH) with COVID-19 is under debate. Aim: assessment of the mortality rate and major determinants of death in HIV-infected patients hospitalized with COVID-19 in Spain before vaccine availability. Design: Retrospective nationwide public database analysis.
Nationwide, retrospective, observational analysis of all hospitalizations with COVID-19 during year 2020 in Spain. Stratification was made according to HIV status. The National Registry of Hospital Discharges was used with the ICD-10 coding list.
A total of 117 694 adults were hospitalized with COVID-19 during 2020. Only 234 (0.2%) were HIV-positives. More than 95% were on antiretroviral therapy. Compared to HIV-negatives, PWH were younger (mean age 53.2 vs. 66.5 years old; P<0.001) and more frequently male (74.8% vs. 56.6%; P<0.001). Most co-morbidities predisposing to severe COVID-19 (diabetes, hypertension, dementia and cardiovascular disease) were more frequent in HIV-negatives. In contrast, the rate of baseline liver disease was over 6-fold higher in PWH (27.4% vs. 4.4%; P<0.001). In-hospital mortality was lower in PWH (9.4% vs. 16%; P=0.004). In multivariate analysis, older age, dementia and especially advanced liver disease (relative risk (RR): 7.6) were the major determinants of death in PWH hospitalized with COVID-19.
HIV-infected patients hospitalized in Spain with COVID-19 during 2020 had better survival than HIV-negatives, most likely explained by younger age and lower rate of co-morbidities. However, advanced liver disease was a major predictor of death in PWH hospitalized with COVID-19.</description><subject>Aged</subject><subject>COVID-19 - complications</subject><subject>Dementia</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - complications</subject><subject>HIV Infections - epidemiology</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Retrospective Studies</subject><issn>1460-2725</issn><issn>1460-2393</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtPAjEUhRujEUSXbs0s3VT6mul0afABhgQXyrZpO51QMi_aEsO_tyiszsnNd8_iA-AeoyeMBJ3utq2tphujDMH5BRhjViBIqKCX585JPgI3IWwRQoyz8hqMaJFaSfEYfHx6WzkTex-yvs5cBzd9GFxUTdb2PoWLh3TN5os1dF1tTbRVNqjobBdD9uPiJput1osXiMUtuKpVE-zdKSfg--31azaHy9X7Yva8hIZSEiEuqK4FrpnGZU2UqXKjhVYF48RwywwTpGAlFlaXWlmuMSNKKZtalZ4wpRPw-L87-H63tyHK1gVjm0Z1tt8HSTgSCHOa84TCf9T4PgRvazl41yp_kBjJoz75p0-e9CX-4TS918f7mT77or9Oz2zn</recordid><startdate>20230214</startdate><enddate>20230214</enddate><creator>Moreno-Torres, V</creator><creator>de Mendoza, C</creator><creator>Martínez-Urbistondo, M</creator><creator>Mills, P</creator><creator>Treviño, A</creator><creator>de la Fuente, S</creator><creator>Díaz de Santiago, A</creator><creator>Calderón-Parra, J</creator><creator>Pintos-Pascual, I</creator><creator>Corpas, M</creator><creator>Soriano, V</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4624-5199</orcidid></search><sort><creationdate>20230214</creationdate><title>Predictors of in-hospital mortality in HIV-infected patients with COVID-19</title><author>Moreno-Torres, V ; de Mendoza, C ; Martínez-Urbistondo, M ; Mills, P ; Treviño, A ; de la Fuente, S ; Díaz de Santiago, A ; Calderón-Parra, J ; Pintos-Pascual, I ; Corpas, M ; Soriano, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c332t-163bf91f4b18f2acd5cb9ba6472c7e4c49264819eb8bae7b142aaaee7bd1f4133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>COVID-19 - complications</topic><topic>Dementia</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - complications</topic><topic>HIV Infections - epidemiology</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreno-Torres, V</creatorcontrib><creatorcontrib>de Mendoza, C</creatorcontrib><creatorcontrib>Martínez-Urbistondo, M</creatorcontrib><creatorcontrib>Mills, P</creatorcontrib><creatorcontrib>Treviño, A</creatorcontrib><creatorcontrib>de la Fuente, S</creatorcontrib><creatorcontrib>Díaz de Santiago, A</creatorcontrib><creatorcontrib>Calderón-Parra, J</creatorcontrib><creatorcontrib>Pintos-Pascual, I</creatorcontrib><creatorcontrib>Corpas, M</creatorcontrib><creatorcontrib>Soriano, V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>QJM : An International Journal of Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreno-Torres, V</au><au>de Mendoza, C</au><au>Martínez-Urbistondo, M</au><au>Mills, P</au><au>Treviño, A</au><au>de la Fuente, S</au><au>Díaz de Santiago, A</au><au>Calderón-Parra, J</au><au>Pintos-Pascual, I</au><au>Corpas, M</au><au>Soriano, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of in-hospital mortality in HIV-infected patients with COVID-19</atitle><jtitle>QJM : An International Journal of Medicine</jtitle><addtitle>QJM</addtitle><date>2023-02-14</date><risdate>2023</risdate><volume>116</volume><issue>1</issue><spage>57</spage><epage>62</epage><pages>57-62</pages><issn>1460-2725</issn><eissn>1460-2393</eissn><abstract>Underlying immunodeficiency is associated with severe COVID-19, but the prognosis of persons with human immunodeficiency virus (HIV) (PWH) with COVID-19 is under debate. Aim: assessment of the mortality rate and major determinants of death in HIV-infected patients hospitalized with COVID-19 in Spain before vaccine availability. Design: Retrospective nationwide public database analysis.
Nationwide, retrospective, observational analysis of all hospitalizations with COVID-19 during year 2020 in Spain. Stratification was made according to HIV status. The National Registry of Hospital Discharges was used with the ICD-10 coding list.
A total of 117 694 adults were hospitalized with COVID-19 during 2020. Only 234 (0.2%) were HIV-positives. More than 95% were on antiretroviral therapy. Compared to HIV-negatives, PWH were younger (mean age 53.2 vs. 66.5 years old; P<0.001) and more frequently male (74.8% vs. 56.6%; P<0.001). Most co-morbidities predisposing to severe COVID-19 (diabetes, hypertension, dementia and cardiovascular disease) were more frequent in HIV-negatives. In contrast, the rate of baseline liver disease was over 6-fold higher in PWH (27.4% vs. 4.4%; P<0.001). In-hospital mortality was lower in PWH (9.4% vs. 16%; P=0.004). In multivariate analysis, older age, dementia and especially advanced liver disease (relative risk (RR): 7.6) were the major determinants of death in PWH hospitalized with COVID-19.
HIV-infected patients hospitalized in Spain with COVID-19 during 2020 had better survival than HIV-negatives, most likely explained by younger age and lower rate of co-morbidities. However, advanced liver disease was a major predictor of death in PWH hospitalized with COVID-19.</abstract><cop>England</cop><pmid>36047831</pmid><doi>10.1093/qjmed/hcac215</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4624-5199</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Aged COVID-19 - complications Dementia Female HIV HIV Infections - complications HIV Infections - epidemiology Hospital Mortality Humans Male Middle Aged Retrospective Studies |
| title | Predictors of in-hospital mortality in HIV-infected patients with COVID-19 |
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