Identification of the Components of Proton Pump Inhibitors and Potassium-Competitive Acid Blocker That Lead to Cardiovascular Events in Working-Age Individuals: A 12-Month Retrospective Cohort Study Using a Large Claims Database

This study aimed to identify the components of proton pump inhibitors (PPIs) or potassium-competitive acid blocker (PCAB) that lead to cardiovascular events in individuals of working age. We analyzed large claims data of individuals who were administered PPIs or PCAB. We enrolled working-age individ...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2022/09/01, Vol.45(9), pp.1373-1377
Hauptverfasser:	Watanabe, Ayako, Momo, Kenji, Tanaka, Katsumi, Uchikura, Takeshi, Kiryu, Yoshihiro, Niiyama, Kanami, Kodaira, Norihisa, Matsuzaki, Airi, Sasaki, Tadanori
Format:	Artikel
Sprache:	eng
Schlagworte:	Age cardiovascular disease Cardiovascular diseases claim-data Cohort analysis Diabetes mellitus Omeprazole Potassium potassium-competitive acid blocker proton pump inhibitor Proton pump inhibitors
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Beschreibung
Zusammenfassung:	This study aimed to identify the components of proton pump inhibitors (PPIs) or potassium-competitive acid blocker (PCAB) that lead to cardiovascular events in individuals of working age. We analyzed large claims data of individuals who were administered PPIs or PCAB. We enrolled working-age individuals administered PPI or PCAB without cardiovascular history with a 12-month screening and 12-month observation period and determined the proportion of cardiovascular events and the predictive factors of cardiovascular events in this population. Among the eligible individuals, 0.5% (456/91098) had cardiovascular events during the 12-month observation period. Predictive factors for cardiovascular events were age for +1 year (p
ISSN:	0918-6158 1347-5215
DOI:	10.1248/bpb.b22-00367