Klotho restoration via ACE2 activation: A potential therapeutic strategy against acute kidney injury-diabetes comorbidity

Acute kidney injury (AKI) is a collection of clinical syndromes with persistent increases in morbidity and mortality rates. Hyperglycemia is a risk factor for AKI development. Renin-angiotensin-aldosterone system (RAS) disequilibrium and Klotho downregulation also play a pivotal role in the pathogen...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular basis of disease 2022-12, Vol.1868 (12), p.166532-166532, Article 166532
Hauptverfasser:	Kale, Ajinath, Shelke, Vishwadeep, Sankrityayan, Himanshu, Dagar, Neha, Gaikwad, Anil Bhanudas
Format:	Artikel
Sprache:	eng
Schlagworte:	ACE2 Acute kidney injury Diminazene aceturate Hyperglycemia Klotho MLN-4760
Online-Zugang:	Volltext
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