The First Dipeptide Mimetic of Neurotrofin-3: Design and Pharmacological Properties

The dimeric dipeptide mimetic hexamethylenediamide bis -( N -monosuccinyl- L -asparaginyl- L -asparagine) (GTS-301) was created on the basis of the structure of the exposed region of the neurotrophin-3 4th loop. The new compound, as well as the full-length neurotrophin, activated the TrkC and TrkB r...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2022-08, Vol.505 (1), p.160-165
Hauptverfasser:	Gudasheva, T. A., Sazonova, N. M., Tarasiuk, A. V., Logvinov, I. O., Antipova, T. A., Nikiforov, D. M., Povarnina, P. Yu, Seredenin, S. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressants Asparagine Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Hippocampus Life Sciences Molecular Biology Neuroprotection Neurotrophin 3 Oxidative stress Toxicity TrkB receptors
Online-Zugang:	Volltext
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