S100A8/A9 drives the formation of procoagulant platelets through GPIbα

•S100A8/A9 plasma levels are increased in patients with COVID-19, and sustained high levels are associated with worse clinical outcome.•S100A8/A9 induces the formation of procoagulant platelets through GPIbα supporting fibrin generation and immune-driven thrombosis. [Display omitted] S100A8/A9, also...

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Veröffentlicht in:	Blood 2022-12, Vol.140 (24), p.2626-2643
Hauptverfasser:	Colicchia, Martina, Schrottmaier, Waltraud C., Perrella, Gina, Reyat, Jasmeet S., Begum, Jenefa, Slater, Alexandre, Price, Joshua, Clark, Joanne C., Zhi, Zhaogong, Simpson, Megan J., Bourne, Joshua H., Poulter, Natalie S., Khan, Abdullah O., Nicolson, Phillip L. R., Pugh, Matthew, Harrison, Paul, Iqbal, Asif J., Rainger, George E., Watson, Steve P., Thomas, Mark R., Mutch, Nicola J., Assinger, Alice, Rayes, Julie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autopsy Blood Platelets - metabolism Calgranulin A - metabolism Calgranulin B - metabolism COVID-19 - metabolism Fibrin - metabolism Humans Mice Phosphatidylserines - metabolism Platelet Aggregation Platelet Glycoprotein GPIb-IX Complex - metabolism
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