Long-term survival in colorectal liver metastasis
Introduction Liver resection is the best treatment option for patients with resectable colorectal liver metastasis (CRLM). A 10-year follow-up can reflect the true curative potential of resection. This retrospective study investigated factors for long-term survival of CRLM patients. Method Data of p...
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| creator | She, Wong Hoi Cheung, Tan To Tsang, Simon H. Y. Dai, Wing Chiu Lam, Ka On Chan, Albert C. Y. Lo, Chung Mau |
| description | Introduction
Liver resection is the best treatment option for patients with resectable colorectal liver metastasis (CRLM). A 10-year follow-up can reflect the true curative potential of resection. This retrospective study investigated factors for long-term survival of CRLM patients.
Method
Data of patients who underwent liver resection for CRLM without extrahepatic disease from 1990 to 2012 at our hospital were reviewed. Patients who survived for > 10 years were compared with those who survived for |
| doi_str_mv | 10.1007/s00423-022-02661-y |
| format | Article |
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Liver resection is the best treatment option for patients with resectable colorectal liver metastasis (CRLM). A 10-year follow-up can reflect the true curative potential of resection. This retrospective study investigated factors for long-term survival of CRLM patients.
Method
Data of patients who underwent liver resection for CRLM without extrahepatic disease from 1990 to 2012 at our hospital were reviewed. Patients who survived for > 10 years were compared with those who survived for < 10 years.
Results
Totally, 315 patients were included in the study. They were divided into 2 groups: < 10-year group and > 10-year group. Patients in the < 10-year group had more tumor nodules (
P
= 0.016), more bilobar involvement (P = 0.004), narrower resection margin (
P
< 0.001), and worse disease-free and overall survival (P < 0.001). On multivariate analysis, low preoperative hemoglobin level, large number of tumor nodules, and bilobar involvement were poor prognostic factors for overall survival, while adjuvant chemotherapy was a favorable factor. Further analysis of patients with bilobar disease showed that perioperative blood transfusion was a poor prognostic factor for overall survival while adjuvant chemotherapy was a favorable one. In patients with multiple bilobar tumor nodules, adjuvant chemotherapy had a positive impact on disease-free survival and overall survival.
Conclusions
Patients who survived for > 10 years after liver resection for CRLM tended to have normal preoperative hemoglobin level, unilobar disease, fewer tumor nodules, and have received adjuvant chemotherapy. Adjuvant chemotherapy favorably affected long-term survival of CRLM patients.</description><identifier>ISSN: 1435-2451</identifier><identifier>EISSN: 1435-2451</identifier><identifier>DOI: 10.1007/s00423-022-02661-y</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abdominal Surgery ; Cardiac Surgery ; General Surgery ; Medicine ; Medicine & Public Health ; Original Article ; Thoracic Surgery ; Traumatic Surgery ; Vascular Surgery</subject><ispartof>Langenbeck's archives of surgery, 2022-12, Vol.407 (8), p.3533-3541</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2022. Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c324t-2053837f1a502dcd47333230bdfea75904d865d708bf5c1c583eb45052331c273</citedby><cites>FETCH-LOGICAL-c324t-2053837f1a502dcd47333230bdfea75904d865d708bf5c1c583eb45052331c273</cites><orcidid>0000-0003-2049-3140</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00423-022-02661-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00423-022-02661-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>She, Wong Hoi</creatorcontrib><creatorcontrib>Cheung, Tan To</creatorcontrib><creatorcontrib>Tsang, Simon H. Y.</creatorcontrib><creatorcontrib>Dai, Wing Chiu</creatorcontrib><creatorcontrib>Lam, Ka On</creatorcontrib><creatorcontrib>Chan, Albert C. Y.</creatorcontrib><creatorcontrib>Lo, Chung Mau</creatorcontrib><title>Long-term survival in colorectal liver metastasis</title><title>Langenbeck's archives of surgery</title><addtitle>Langenbecks Arch Surg</addtitle><description>Introduction
Liver resection is the best treatment option for patients with resectable colorectal liver metastasis (CRLM). A 10-year follow-up can reflect the true curative potential of resection. This retrospective study investigated factors for long-term survival of CRLM patients.
Method
Data of patients who underwent liver resection for CRLM without extrahepatic disease from 1990 to 2012 at our hospital were reviewed. Patients who survived for > 10 years were compared with those who survived for < 10 years.
Results
Totally, 315 patients were included in the study. They were divided into 2 groups: < 10-year group and > 10-year group. Patients in the < 10-year group had more tumor nodules (
P
= 0.016), more bilobar involvement (P = 0.004), narrower resection margin (
P
< 0.001), and worse disease-free and overall survival (P < 0.001). On multivariate analysis, low preoperative hemoglobin level, large number of tumor nodules, and bilobar involvement were poor prognostic factors for overall survival, while adjuvant chemotherapy was a favorable factor. Further analysis of patients with bilobar disease showed that perioperative blood transfusion was a poor prognostic factor for overall survival while adjuvant chemotherapy was a favorable one. In patients with multiple bilobar tumor nodules, adjuvant chemotherapy had a positive impact on disease-free survival and overall survival.
Conclusions
Patients who survived for > 10 years after liver resection for CRLM tended to have normal preoperative hemoglobin level, unilobar disease, fewer tumor nodules, and have received adjuvant chemotherapy. Adjuvant chemotherapy favorably affected long-term survival of CRLM patients.</description><subject>Abdominal Surgery</subject><subject>Cardiac Surgery</subject><subject>General Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Thoracic Surgery</subject><subject>Traumatic Surgery</subject><subject>Vascular Surgery</subject><issn>1435-2451</issn><issn>1435-2451</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kE9LxDAQxYMouK5-AU89eolOZpKmexTxHyx40XPIpunSpW3WpF3Yb2-0HjwJM8wMvPdgfoxdC7gVAPouAUgkDoi5y1Lw4wlbCEmKo1Ti9M9-zi5S2gFAqVdywcQ6DFs--tgXaYqH9mC7oh0KF7oQvRvz1bUHH4vejzblatMlO2tsl_zV71yyj6fH94cXvn57fn24X3NHKEeOoKgi3QirAGtXS01ESLCpG2-1WoGsq1LVGqpNo5xwqiK_kQoUEgmHmpbsZs7dx_A5-TSavk3Od50dfJiSQQ26FBpz6JLhLHUxpBR9Y_ax7W08GgHmm4-Z-ZjMx_zwMcdsotmUsnjY-mh2YYpDfuk_1xegS2dh</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>She, Wong Hoi</creator><creator>Cheung, Tan To</creator><creator>Tsang, Simon H. Y.</creator><creator>Dai, Wing Chiu</creator><creator>Lam, Ka On</creator><creator>Chan, Albert C. Y.</creator><creator>Lo, Chung Mau</creator><general>Springer Berlin Heidelberg</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2049-3140</orcidid></search><sort><creationdate>20221201</creationdate><title>Long-term survival in colorectal liver metastasis</title><author>She, Wong Hoi ; Cheung, Tan To ; Tsang, Simon H. Y. ; Dai, Wing Chiu ; Lam, Ka On ; Chan, Albert C. Y. ; Lo, Chung Mau</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c324t-2053837f1a502dcd47333230bdfea75904d865d708bf5c1c583eb45052331c273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Abdominal Surgery</topic><topic>Cardiac Surgery</topic><topic>General Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Thoracic Surgery</topic><topic>Traumatic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>She, Wong Hoi</creatorcontrib><creatorcontrib>Cheung, Tan To</creatorcontrib><creatorcontrib>Tsang, Simon H. Y.</creatorcontrib><creatorcontrib>Dai, Wing Chiu</creatorcontrib><creatorcontrib>Lam, Ka On</creatorcontrib><creatorcontrib>Chan, Albert C. Y.</creatorcontrib><creatorcontrib>Lo, Chung Mau</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langenbeck's archives of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>She, Wong Hoi</au><au>Cheung, Tan To</au><au>Tsang, Simon H. Y.</au><au>Dai, Wing Chiu</au><au>Lam, Ka On</au><au>Chan, Albert C. Y.</au><au>Lo, Chung Mau</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term survival in colorectal liver metastasis</atitle><jtitle>Langenbeck's archives of surgery</jtitle><stitle>Langenbecks Arch Surg</stitle><date>2022-12-01</date><risdate>2022</risdate><volume>407</volume><issue>8</issue><spage>3533</spage><epage>3541</epage><pages>3533-3541</pages><issn>1435-2451</issn><eissn>1435-2451</eissn><abstract>Introduction
Liver resection is the best treatment option for patients with resectable colorectal liver metastasis (CRLM). A 10-year follow-up can reflect the true curative potential of resection. This retrospective study investigated factors for long-term survival of CRLM patients.
Method
Data of patients who underwent liver resection for CRLM without extrahepatic disease from 1990 to 2012 at our hospital were reviewed. Patients who survived for > 10 years were compared with those who survived for < 10 years.
Results
Totally, 315 patients were included in the study. They were divided into 2 groups: < 10-year group and > 10-year group. Patients in the < 10-year group had more tumor nodules (
P
= 0.016), more bilobar involvement (P = 0.004), narrower resection margin (
P
< 0.001), and worse disease-free and overall survival (P < 0.001). On multivariate analysis, low preoperative hemoglobin level, large number of tumor nodules, and bilobar involvement were poor prognostic factors for overall survival, while adjuvant chemotherapy was a favorable factor. Further analysis of patients with bilobar disease showed that perioperative blood transfusion was a poor prognostic factor for overall survival while adjuvant chemotherapy was a favorable one. In patients with multiple bilobar tumor nodules, adjuvant chemotherapy had a positive impact on disease-free survival and overall survival.
Conclusions
Patients who survived for > 10 years after liver resection for CRLM tended to have normal preoperative hemoglobin level, unilobar disease, fewer tumor nodules, and have received adjuvant chemotherapy. Adjuvant chemotherapy favorably affected long-term survival of CRLM patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><doi>10.1007/s00423-022-02661-y</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-2049-3140</orcidid></addata></record> |
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| subjects | Abdominal Surgery Cardiac Surgery General Surgery Medicine Medicine & Public Health Original Article Thoracic Surgery Traumatic Surgery Vascular Surgery |
| title | Long-term survival in colorectal liver metastasis |
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