Nucleolar protein NOC4L inhibits tumorigenesis and progression by attenuating SIRT1-mediated p53 deacetylation

SIRT1 is an NAD + -dependent deacetylase and plays an important role in the deacetylation of both histone and non-histone proteins. Many studies revealed that SIRT1 is upregulated in a variety of tumors and tightly associated with tumorigenesis and cancer progression, but the detailed underlying mec...

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Veröffentlicht in:	Oncogene 2022-09, Vol.41 (39), p.4474-4484
Hauptverfasser:	Jia, Xiaomeng, Liu, Huijiao, Ren, Xinmin, Li, Peng, Song, Runjie, Li, Xiru, Guo, Yangdong, Li, Xiangdong
Format:	Artikel
Sprache:	eng
Schlagworte:	13/2 13/31 14/19 38/61 631/67/395 692/53/2422 82/80 82/83 96/2 Acetylation Apoptosis Cell Biology Cell proliferation Colorectal carcinoma Deacetylation DNA damage Histones Human Genetics Internal Medicine Medical prognosis Medicine Medicine & Public Health Nuclear transport Nucleoli Oncology p53 Protein Proteins SIRT1 protein Tumorigenesis Xenografts
Online-Zugang:	Volltext
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