BORON-ENHANCED BIOLOGICAL EFFECTIVENESS OF PROTON IRRADIATION: STRATEGY TO ASSESS THE UNDERPINNING MECHANISM

BORON-ENHANCED BIOLOGICAL EFFECTIVENESS OF PROTON IRRADIATION: STRATEGY TO ASSESS THE UNDERPINNING MECHANISM

Abstract Proton radiotherapy for the treatment of cancer offers an excellent dose distribution. Cellular experiments have shown that in terms of biological effects, the sharp dose distribution is further amplified, by as much as 75%, in the presence of boron. It is a matter of debate whether the und...

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Veröffentlicht in:Radiation protection dosimetry 2022-08, Vol.198 (9–11), p.527-531
Hauptverfasser: Kundrát, Pavel, Pachnerová Brabcová, Kateřina, Jelínek Michaelidesová, Anna, Zahradníček, Oldřich, Danilová, Irina, Štěpán, Václav, Jamborová, Zuzana, Davídková, Marie
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container_end_page 531
container_issue 9–11
container_start_page 527
container_title Radiation protection dosimetry
container_volume 198
creator Kundrát, Pavel
Pachnerová Brabcová, Kateřina
Jelínek Michaelidesová, Anna
Zahradníček, Oldřich
Danilová, Irina
Štěpán, Václav
Jamborová, Zuzana
Davídková, Marie
description Abstract Proton radiotherapy for the treatment of cancer offers an excellent dose distribution. Cellular experiments have shown that in terms of biological effects, the sharp dose distribution is further amplified, by as much as 75%, in the presence of boron. It is a matter of debate whether the underlying physical processes involve the nuclear reaction of 11B with protons or 10B with secondary neutrons, both producing densely ionizing short-ranged particles. Likewise, potential roles of intercellular communication or boron acting as a radiosensitizer are not clear. We present an ongoing research project based on a multiscale approach to elucidate the mechanism by which boron enhances the effectiveness of proton irradiation in the Bragg peak. It combines experimental with simulation tools to study the physics of proton–boron interactions, and to analyze intra- and inter-cellular boron biology upon proton irradiation.
doi_str_mv 10.1093/rpd/ncac093
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title BORON-ENHANCED BIOLOGICAL EFFECTIVENESS OF PROTON IRRADIATION: STRATEGY TO ASSESS THE UNDERPINNING MECHANISM
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