Targeting the tamoxifen receptor within sodium channels to block osteoarthritic pain

Voltage-gated sodium channels (NaV) in nociceptive neurons initiate action potentials required for transmission of aberrant painful stimuli observed in osteoarthritis (OA). Targeting NaV subtypes with drugs to produce analgesic effects for OA pain management is a developing therapeutic area. Previou...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Cell reports (Cambridge) 2022-08, Vol.40 (8), p.111248-111248, Article 111248
Hauptverfasser:	McCollum, Megan M., Larmore, Megan, Ishihara, Shingo, Ng, Leo C.T., Kimura, Louise F., Guadarrama, Eduardo, Ta, My C., Vien, Thuy N., Frost, Grant B., Scheidt, Karl A., Miller, Rachel E., DeCaen, Paul G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials DRG neurons Ganglia, Spinal Humans molecular pharmacology Nociceptors osteoarthritis pain Pain - drug therapy sodium channel Tamoxifen - pharmacology Tamoxifen - therapeutic use Voltage-Gated Sodium Channels
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!