Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions
Abstract Progression of atherosclerotic plaque in coronary arteries is characterized by complex cellular and non-cellular molecular interactions. Within recent years, atherosclerosis has been recognized as inflammation-driven disease condition, where progressive stages are characterized by morpholog...
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| Veröffentlicht in: | European heart journal cardiovascular imaging 2022-12, Vol.24 (1), p.e1-e16 |
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| container_title | European heart journal cardiovascular imaging |
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| creator | Seguchi, Masaru Aytekin, Alp Lenz, Tobias Nicol, Philipp Klosterman, Grace R Beele, Alicia Sabic, Emina Utsch, Léa Alyaqoob, Aseel Gorpas, Dimitris Ntziachristos, Vasilis Jaffer, Farouc A Rauschendorfer, Philipp Joner, Michael |
| description | Abstract
Progression of atherosclerotic plaque in coronary arteries is characterized by complex cellular and non-cellular molecular interactions. Within recent years, atherosclerosis has been recognized as inflammation-driven disease condition, where progressive stages are characterized by morphological changes in plaque composition but also relevant molecular processes resulting in increased plaque vulnerability. While existing intravascular imaging modalities are able to resolve key morphological features during plaque progression, they lack capability to characterize the molecular profile of advanced atherosclerotic plaque. Because hybrid imaging modalities may provide incremental information related to plaque biology, they are expected to provide synergistic effects in detecting high risk patients and lesions. The aim of this article is to review existing literature on intravascular molecular imaging approaches, and to provide clinically oriented proposals of their application. In addition, we assembled an overview of future developments in this field geared towards detection of patients at risk for cardiovascular events.
Graphical Abstract
Graphical Abstract |
| doi_str_mv | 10.1093/ehjci/jeac163 |
| format | Article |
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Progression of atherosclerotic plaque in coronary arteries is characterized by complex cellular and non-cellular molecular interactions. Within recent years, atherosclerosis has been recognized as inflammation-driven disease condition, where progressive stages are characterized by morphological changes in plaque composition but also relevant molecular processes resulting in increased plaque vulnerability. While existing intravascular imaging modalities are able to resolve key morphological features during plaque progression, they lack capability to characterize the molecular profile of advanced atherosclerotic plaque. Because hybrid imaging modalities may provide incremental information related to plaque biology, they are expected to provide synergistic effects in detecting high risk patients and lesions. The aim of this article is to review existing literature on intravascular molecular imaging approaches, and to provide clinically oriented proposals of their application. In addition, we assembled an overview of future developments in this field geared towards detection of patients at risk for cardiovascular events.
Graphical Abstract
Graphical Abstract</description><identifier>ISSN: 2047-2404</identifier><identifier>EISSN: 2047-2412</identifier><identifier>DOI: 10.1093/ehjci/jeac163</identifier><identifier>PMID: 36002376</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Atherosclerosis ; Coronary Artery Disease - pathology ; Humans ; Multimodal Imaging - methods ; Plaque, Atherosclerotic - pathology ; Spectroscopy, Near-Infrared - methods ; Ultrasonography, Interventional - methods</subject><ispartof>European heart journal cardiovascular imaging, 2022-12, Vol.24 (1), p.e1-e16</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c256t-267411b32c5410d86e4e1e42ec75cfd484250de20b5782a51d7e478038964f13</citedby><cites>FETCH-LOGICAL-c256t-267411b32c5410d86e4e1e42ec75cfd484250de20b5782a51d7e478038964f13</cites><orcidid>0000-0001-7980-384X ; 0000-0003-3927-7675 ; 0000-0002-5875-613X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36002376$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seguchi, Masaru</creatorcontrib><creatorcontrib>Aytekin, Alp</creatorcontrib><creatorcontrib>Lenz, Tobias</creatorcontrib><creatorcontrib>Nicol, Philipp</creatorcontrib><creatorcontrib>Klosterman, Grace R</creatorcontrib><creatorcontrib>Beele, Alicia</creatorcontrib><creatorcontrib>Sabic, Emina</creatorcontrib><creatorcontrib>Utsch, Léa</creatorcontrib><creatorcontrib>Alyaqoob, Aseel</creatorcontrib><creatorcontrib>Gorpas, Dimitris</creatorcontrib><creatorcontrib>Ntziachristos, Vasilis</creatorcontrib><creatorcontrib>Jaffer, Farouc A</creatorcontrib><creatorcontrib>Rauschendorfer, Philipp</creatorcontrib><creatorcontrib>Joner, Michael</creatorcontrib><title>Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions</title><title>European heart journal cardiovascular imaging</title><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><description>Abstract
Progression of atherosclerotic plaque in coronary arteries is characterized by complex cellular and non-cellular molecular interactions. Within recent years, atherosclerosis has been recognized as inflammation-driven disease condition, where progressive stages are characterized by morphological changes in plaque composition but also relevant molecular processes resulting in increased plaque vulnerability. While existing intravascular imaging modalities are able to resolve key morphological features during plaque progression, they lack capability to characterize the molecular profile of advanced atherosclerotic plaque. Because hybrid imaging modalities may provide incremental information related to plaque biology, they are expected to provide synergistic effects in detecting high risk patients and lesions. The aim of this article is to review existing literature on intravascular molecular imaging approaches, and to provide clinically oriented proposals of their application. In addition, we assembled an overview of future developments in this field geared towards detection of patients at risk for cardiovascular events.
Graphical Abstract
Graphical Abstract</description><subject>Atherosclerosis</subject><subject>Coronary Artery Disease - pathology</subject><subject>Humans</subject><subject>Multimodal Imaging - methods</subject><subject>Plaque, Atherosclerotic - pathology</subject><subject>Spectroscopy, Near-Infrared - methods</subject><subject>Ultrasonography, Interventional - methods</subject><issn>2047-2404</issn><issn>2047-2412</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUD1PwzAQtRCIVqUjK_LIEmo7jp2yoYpCpUos3SPXuTSuHDvECVL_PS4tZeSG-3x6d_cQuqfkiZJ5OoN6r81sD0pTkV6hMSNcJoxTdn3JCR-haQh7Ei3jgjN6i0apIISlUoxRs3J9p75U0INVHW68hVNmGrUzbveM49gFq_pY4Fb1tW_rQzDe-t0B-wrHDnQ-aHv0JmDjeo_roVEOlyaACoC1d6XpjXfhDt1UygaYnuMEbZavm8V7sv54Wy1e1olmmegTJiSndJsynXFKylwABwqcgZaZrkqec5aREhjZZjJnKqOlBC5zkuZzwSuaTtDjibbt_OcAoS8aEzRYqxz4IRRMEiGpYFRGaHKC6nh-6KAq2i6-3h0KSoqjxsWPxsVZ44h_OFMP2wbKC_pX0b_dfmj_4foG43KI2w</recordid><startdate>20221219</startdate><enddate>20221219</enddate><creator>Seguchi, Masaru</creator><creator>Aytekin, Alp</creator><creator>Lenz, Tobias</creator><creator>Nicol, Philipp</creator><creator>Klosterman, Grace R</creator><creator>Beele, Alicia</creator><creator>Sabic, Emina</creator><creator>Utsch, Léa</creator><creator>Alyaqoob, Aseel</creator><creator>Gorpas, Dimitris</creator><creator>Ntziachristos, Vasilis</creator><creator>Jaffer, Farouc A</creator><creator>Rauschendorfer, Philipp</creator><creator>Joner, Michael</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7980-384X</orcidid><orcidid>https://orcid.org/0000-0003-3927-7675</orcidid><orcidid>https://orcid.org/0000-0002-5875-613X</orcidid></search><sort><creationdate>20221219</creationdate><title>Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions</title><author>Seguchi, Masaru ; Aytekin, Alp ; Lenz, Tobias ; Nicol, Philipp ; Klosterman, Grace R ; Beele, Alicia ; Sabic, Emina ; Utsch, Léa ; Alyaqoob, Aseel ; Gorpas, Dimitris ; Ntziachristos, Vasilis ; Jaffer, Farouc A ; Rauschendorfer, Philipp ; Joner, Michael</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c256t-267411b32c5410d86e4e1e42ec75cfd484250de20b5782a51d7e478038964f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Atherosclerosis</topic><topic>Coronary Artery Disease - pathology</topic><topic>Humans</topic><topic>Multimodal Imaging - methods</topic><topic>Plaque, Atherosclerotic - pathology</topic><topic>Spectroscopy, Near-Infrared - methods</topic><topic>Ultrasonography, Interventional - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seguchi, Masaru</creatorcontrib><creatorcontrib>Aytekin, Alp</creatorcontrib><creatorcontrib>Lenz, Tobias</creatorcontrib><creatorcontrib>Nicol, Philipp</creatorcontrib><creatorcontrib>Klosterman, Grace R</creatorcontrib><creatorcontrib>Beele, Alicia</creatorcontrib><creatorcontrib>Sabic, Emina</creatorcontrib><creatorcontrib>Utsch, Léa</creatorcontrib><creatorcontrib>Alyaqoob, Aseel</creatorcontrib><creatorcontrib>Gorpas, Dimitris</creatorcontrib><creatorcontrib>Ntziachristos, Vasilis</creatorcontrib><creatorcontrib>Jaffer, Farouc A</creatorcontrib><creatorcontrib>Rauschendorfer, Philipp</creatorcontrib><creatorcontrib>Joner, Michael</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European heart journal cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seguchi, Masaru</au><au>Aytekin, Alp</au><au>Lenz, Tobias</au><au>Nicol, Philipp</au><au>Klosterman, Grace R</au><au>Beele, Alicia</au><au>Sabic, Emina</au><au>Utsch, Léa</au><au>Alyaqoob, Aseel</au><au>Gorpas, Dimitris</au><au>Ntziachristos, Vasilis</au><au>Jaffer, Farouc A</au><au>Rauschendorfer, Philipp</au><au>Joner, Michael</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions</atitle><jtitle>European heart journal cardiovascular imaging</jtitle><addtitle>Eur Heart J Cardiovasc Imaging</addtitle><date>2022-12-19</date><risdate>2022</risdate><volume>24</volume><issue>1</issue><spage>e1</spage><epage>e16</epage><pages>e1-e16</pages><issn>2047-2404</issn><eissn>2047-2412</eissn><abstract>Abstract
Progression of atherosclerotic plaque in coronary arteries is characterized by complex cellular and non-cellular molecular interactions. Within recent years, atherosclerosis has been recognized as inflammation-driven disease condition, where progressive stages are characterized by morphological changes in plaque composition but also relevant molecular processes resulting in increased plaque vulnerability. While existing intravascular imaging modalities are able to resolve key morphological features during plaque progression, they lack capability to characterize the molecular profile of advanced atherosclerotic plaque. Because hybrid imaging modalities may provide incremental information related to plaque biology, they are expected to provide synergistic effects in detecting high risk patients and lesions. The aim of this article is to review existing literature on intravascular molecular imaging approaches, and to provide clinically oriented proposals of their application. In addition, we assembled an overview of future developments in this field geared towards detection of patients at risk for cardiovascular events.
Graphical Abstract
Graphical Abstract</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>36002376</pmid><doi>10.1093/ehjci/jeac163</doi><orcidid>https://orcid.org/0000-0001-7980-384X</orcidid><orcidid>https://orcid.org/0000-0003-3927-7675</orcidid><orcidid>https://orcid.org/0000-0002-5875-613X</orcidid></addata></record> |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Atherosclerosis Coronary Artery Disease - pathology Humans Multimodal Imaging - methods Plaque, Atherosclerotic - pathology Spectroscopy, Near-Infrared - methods Ultrasonography, Interventional - methods |
| title | Intravascular molecular imaging: translating pathophysiology of atherosclerosis into human disease conditions |
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